E41LA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E41LA_HUMAN
• UniProt AC: Q9HCS5
• Protein Name: Band 4.1-like protein 4A
• Gene Name: EPB41L4A
• Organism: Homo sapiens (Human).
• Sequence Length: 686
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Sequence: MGCFCAVPEEFYCEVLLLDESKLTLTTQQQGIKKSTKGSVVLDHVFHHVNLVEIDYFGLRYCDRSHQTYWLDPAKTLAEHKELINTGPPYTLYFGIKFYAEDPCKLKEEITRYQFFLQVKQDVLQGRLPCPVNTAAQLGAYAIQSELGDYDPYKHTAGYVSEYRFVPDQKEELEEAIERIHKTLMGQIPSEAELNYLRTAKSLEMYGVDLHPVYGENKSEYFLGLTPVGVVVYKNKKQVGKYFWPRITKVHFKETQFELRVLGKDCNETSFFFEARSKTACKHLWKCSVEHHTFFRMPENESNSLSRKLSKFGSIRYKHRYSGRTALQMSRDLSIQLPRPDQNVTRSRSKTYPKRIAQTQPAESNSISRITANMENGENEGTIKIIAPSPVKSFKKAKNENSPDTQRSKSHAPWEENGPQSGLYNSPSDRTKSPKFPYTRRRNPSCGSDNDSVQPVRRRKAHNSGEDSDLKQRRRSRSRCNTSSGSESENSNREYRKKRNRIRQENDMVDSAPQWEAVLRRQKEKNQADPNNRRSRHRSRSRSPDIQAKEELWKHIQKELVDPSGLSEEQLKEIPYTKIETQGDPIRIRHSHSPRSYRQYRRSQCSDGERSVLSEVNSKTDLVPPLPVTRSSDAQGSGDATVHQRRNGSKDSLMEEKPQTSTNNLAGKHTAKTIKTIQASRLKTET

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Phosphorylation	QQQGIKKSTKGSVVL HHHCCCCCCCCCCHH	30.28	26670566
36	Phosphorylation	QQGIKKSTKGSVVLD HHCCCCCCCCCCHHH	48.59	26670566
170	Ubiquitination	YRFVPDQKEELEEAI EEECCCCHHHHHHHH	61.61	-
182	Ubiquitination	EAIERIHKTLMGQIP HHHHHHHHHHHCCCC	40.77	-
183	Phosphorylation	AIERIHKTLMGQIPS HHHHHHHHHHCCCCC	14.07	27762562
190	Phosphorylation	TLMGQIPSEAELNYL HHHCCCCCHHHHHHH	51.58	22210691
196	Phosphorylation	PSEAELNYLRTAKSL CCHHHHHHHHHCCCH	15.36	-
242	Phosphorylation	NKKQVGKYFWPRITK CCCCCCCCCCCCEEE	12.63	-
269	Phosphorylation	LGKDCNETSFFFEAR CCCCCCCCCEEEEEC	19.49	28270605
270	Phosphorylation	GKDCNETSFFFEARS CCCCCCCCEEEEECC	17.55	28270605
277	Phosphorylation	SFFFEARSKTACKHL CEEEEECCCHHHHHH	41.21	28270605
279	Phosphorylation	FFEARSKTACKHLWK EEEECCCHHHHHHHC	38.24	28270605
302	Phosphorylation	FRMPENESNSLSRKL CCCCCCCCCCHHHHH	43.21	20363803
304	Phosphorylation	MPENESNSLSRKLSK CCCCCCCCHHHHHHH	36.68	21815630
306	Phosphorylation	ENESNSLSRKLSKFG CCCCCCHHHHHHHHC	27.47	24260401
310	Phosphorylation	NSLSRKLSKFGSIRY CCHHHHHHHHCCCEE	29.04	23401153
314	Phosphorylation	RKLSKFGSIRYKHRY HHHHHHCCCEEEECC	13.66	30108239
334	Phosphorylation	LQMSRDLSIQLPRPD EHCCCCCCCCCCCCC	16.75	28555341
352	Phosphorylation	TRSRSKTYPKRIAQT CHHCCCCCCCHHCCC	15.53	21214269
364	Phosphorylation	AQTQPAESNSISRIT CCCCCCCCCCCEEEE	37.67	21214269
366	Phosphorylation	TQPAESNSISRITAN CCCCCCCCCEEEEEE	31.08	21214269
368	Phosphorylation	PAESNSISRITANME CCCCCCCEEEEEECC	19.90	29978859
389	Phosphorylation	TIKIIAPSPVKSFKK EEEEEECCCCHHHHH	33.05	22167270
393	Phosphorylation	IAPSPVKSFKKAKNE EECCCCHHHHHHCCC	42.40	22167270
402	Phosphorylation	KKAKNENSPDTQRSK HHHCCCCCCCCHHHH	20.27	17081983
405	Phosphorylation	KNENSPDTQRSKSHA CCCCCCCCHHHHCCC	29.30	30242111
410	Phosphorylation	PDTQRSKSHAPWEEN CCCHHHHCCCCCHHC	26.57	-
424	Phosphorylation	NGPQSGLYNSPSDRT CCCCCCCCCCCCCCC	19.67	26356563
426	Phosphorylation	PQSGLYNSPSDRTKS CCCCCCCCCCCCCCC	16.54	22167270
428	Phosphorylation	SGLYNSPSDRTKSPK CCCCCCCCCCCCCCC	39.27	22167270
431	Phosphorylation	YNSPSDRTKSPKFPY CCCCCCCCCCCCCCC	40.64	23403867
433	Phosphorylation	SPSDRTKSPKFPYTR CCCCCCCCCCCCCCC	32.48	24719451
445	Phosphorylation	YTRRRNPSCGSDNDS CCCCCCCCCCCCCCC	34.36	22167270
448	Phosphorylation	RRNPSCGSDNDSVQP CCCCCCCCCCCCCCC	37.25	22167270
452	Phosphorylation	SCGSDNDSVQPVRRR CCCCCCCCCCCHHHH	28.98	30576142
464	Phosphorylation	RRRKAHNSGEDSDLK HHHHHHCCCCCCHHH	33.42	30576142
468	Phosphorylation	AHNSGEDSDLKQRRR HHCCCCCCHHHHHHH	40.31	21955146
511	Phosphorylation	QENDMVDSAPQWEAV HHHCCCCCHHHHHHH	30.36	29449344
539	Phosphorylation	NRRSRHRSRSRSPDI CHHHHHHHHHCCCCH	28.60	30576142
541	Phosphorylation	RSRHRSRSRSPDIQA HHHHHHHHCCCCHHH	38.05	22167270
543	Phosphorylation	RHRSRSRSPDIQAKE HHHHHHCCCCHHHHH	28.33	22167270
576	Phosphorylation	EQLKEIPYTKIETQG HHHHHCCCCEEEECC	26.73	28674419
600	Phosphorylation	SPRSYRQYRRSQCSD CCCCHHHHHHHHCCC	10.05	28102081
603	Phosphorylation	SYRQYRRSQCSDGER CHHHHHHHHCCCCCC	26.92	23898821
606	Phosphorylation	QYRRSQCSDGERSVL HHHHHHCCCCCCHHH	40.80	23898821
614	Phosphorylation	DGERSVLSEVNSKTD CCCCHHHHHHCCCCC	37.02	28674419
629	O-linked_Glycosylation	LVPPLPVTRSSDAQG CCCCCCCCCCCCCCC	23.93	28657654
649	Phosphorylation	VHQRRNGSKDSLMEE EEECCCCCCCCCCCC	36.52	24719451
652	Phosphorylation	RRNGSKDSLMEEKPQ CCCCCCCCCCCCCCC	33.09	23927012
660	Phosphorylation	LMEEKPQTSTNNLAG CCCCCCCCCCCCCCC	46.15	21955146
661	Phosphorylation	MEEKPQTSTNNLAGK CCCCCCCCCCCCCCH	24.72	21955146
662	Phosphorylation	EEKPQTSTNNLAGKH CCCCCCCCCCCCCHH	31.36	21955146
672	Acetylation	LAGKHTAKTIKTIQA CCCHHHHHHHHHHHH	52.52	12649541

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E41LA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E41LA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E41LA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-402, AND MASSSPECTROMETRY.
PubMed: 17081983