| UniProt ID | RYK_HUMAN | |
|---|---|---|
| UniProt AC | P34925 | |
| Protein Name | Tyrosine-protein kinase RYK {ECO:0000305} | |
| Gene Name | RYK {ECO:0000312|HGNC:HGNC:10481} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 607 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. Nucleus. Cytoplasm. In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.. |
|
| Protein Description | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.. | |
| Protein Sequence | MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 59 | O-linked_Glycosylation | PPELQSASAGPSVSL CHHHHCCCCCCCEEE | 31.13 | OGP | |
| 136 | N-linked_Glycosylation | NVLAMDMPQVNISVQ CEEEECCCCEEEEEC | 18.64 | UniProtKB CARBOHYD | |
| 139 | N-linked_Glycosylation | AMDMPQVNISVQGEV EECCCCEEEEECCCC | 8.20 | - | |
| 171 | N-linked_Glycosylation | DSEVMILMQLNLTVN CCEEEEEEEEEEEEC | 19.44 | UniProtKB CARBOHYD | |
| 174 | N-linked_Glycosylation | VMILMQLNLTVNSSK EEEEEEEEEEECCCC | 8.03 | - | |
| 175 | N-linked_Glycosylation | MILMQLNLTVNSSKN EEEEEEEEEECCCCC | 35.02 | UniProtKB CARBOHYD | |
| 178 | N-linked_Glycosylation | MQLNLTVNSSKNFTV EEEEEEECCCCCEEE | 56.77 | - | |
| 179 | N-linked_Glycosylation | QLNLTVNSSKNFTVL EEEEEECCCCCEEEE | 39.51 | UniProtKB CARBOHYD | |
| 182 | N-linked_Glycosylation | LTVNSSKNFTVLNFK EEECCCCCEEEEEEE | 3.44 | - | |
| 194 | Sumoylation | NFKRRKMCYKKLEEV EEEECCHHHHHHHHH | 34.36 | - | |
| 201 | Phosphorylation | CYKKLEEVKTSALDK HHHHHHHHHHHHCCC | 22.55 | 22468782 | |
| 206 | N-linked_Glycosylation | EEVKTSALDKNTSRT HHHHHHHCCCCCCCC | 42.84 | UniProtKB CARBOHYD | |
| 209 | N-linked_Glycosylation | KTSALDKNTSRTIYD HHHHCCCCCCCCCCC | 24.09 | - | |
| 210 | Phosphorylation | TSALDKNTSRTIYDP HHHCCCCCCCCCCCC | 24.53 | 22468782 | |
| 213 | O-linked_Glycosylation | LDKNTSRTIYDPVHA CCCCCCCCCCCCCCC | 34.59 | OGP | |
| 220 | Phosphorylation | TIYDPVHAAPTTSTR CCCCCCCCCCCCCCC | 28.75 | 22468782 | |
| 280 | Phosphorylation | LSQPSTQTTQYLRAD CCCCCCCHHHEEECC | 8.96 | 29759185 | |
| 285 (in isoform 2) | Phosphorylation | - | 27.25 | 25850435 | |
| 285 | Phosphorylation | TQTTQYLRADTPNNA CCHHHEEECCCCCCC | 27.25 | 25850435 | |
| 288 | Phosphorylation | TQYLRADTPNNATPI HHEEECCCCCCCCCC | 46.52 | 24719451 | |
| 288 | Phosphorylation | TQYLRADTPNNATPI HHEEECCCCCCCCCC | 46.52 | 25850435 | |
| 290 (in isoform 2) | Phosphorylation | - | 19.83 | 22210691 | |
| 293 | Phosphorylation | ADTPNNATPITSYPT CCCCCCCCCCCCCCE | 24.34 | 22210691 | |
| 294 | Phosphorylation | DTPNNATPITSYPTL CCCCCCCCCCCCCEE | 29.81 | - | |
| 297 | Phosphorylation | NNATPITSYPTLRIE CCCCCCCCCCEEEEE | 22.04 | - | |
| 323 | Phosphorylation | AKGKVKDIAISRERI ECCCEEEEEEECCEE | 21.04 | 24719451 | |
| 326 | Phosphorylation | KVKDIAISRERITLK CEEEEEEECCEEEHH | 26.53 | 24719451 | |
| 328 | Phosphorylation | KDIAISRERITLKDV EEEEEECCEEEHHHH | 33.70 | - | |
| 329 | Phosphorylation | DIAISRERITLKDVL EEEEECCEEEHHHHH | 4.08 | 24719451 | |
| 337 | Phosphorylation | ITLKDVLQEGTFGRI EEHHHHHHHCCCHHH | 23.36 | - | |
| 350 | Ubiquitination | RIFHGILIDEKDPNK HHCCEEEECCCCCCH | 74.80 | 2190698 | |
| 353 (in isoform 1) | Ubiquitination | - | 75.22 | 21906983 | |
| 356 (in isoform 2) | Ubiquitination | - | 48.84 | 21906983 | |
| 356 | Ubiquitination | LIDEKDPNKEKQAFV EECCCCCCHHHHHHH | 48.84 | - | |
| 368 | Phosphorylation | AFVKTVKDQASEIQV HHHHHHHHHHHHHHH | 29.60 | - | |
| 373 | Phosphorylation | VKDQASEIQVTMMLT HHHHHHHHHHEEEHH | 4.78 | - | |
| 377 | Phosphorylation | ASEIQVTMMLTESCK HHHHHHEEEHHHCCH | 14.14 | - | |
| 379 | Phosphorylation | EIQVTMMLTESCKLR HHHHEEEHHHCCHHC | 16.00 | - | |
| 388 | Methylation | ESCKLRGLHHRNLLP HCCHHCCCCCCCCCC | 25.41 | - | |
| 403 | Methylation | ITHVCIEEGEKPMVI EEEEEECCCCCCEEE | 49.63 | - | |
| 417 | Methylation | ILPYMNWGNLKLFLR EEECCCCCCHHHHHH | 40.99 | - | |
| 492 | Phosphorylation | ALSRDLFPMDYHCLG CCCCCCCCCCEECCC | 6.54 | - | |
| 495 | Phosphorylation | RDLFPMDYHCLGDNE CCCCCCCEECCCCCC | 6.51 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RYK_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RYK_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RYK_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
