NCKP1_HUMAN - dbPTM
NCKP1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NCKP1_HUMAN
UniProt AC Q9Y2A7
Protein Name Nck-associated protein 1
Gene Name NCKAP1
Organism Homo sapiens (Human).
Sequence Length 1128
Subcellular Localization Cell membrane
Single-pass membrane protein
Cytoplasmic side . Cell projection, lamellipodium membrane
Single-pass membrane protein
Cytoplasmic side . At the interface between the lamellipodial actin meshwork and the membrane.
Protein Description Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes..
Protein Sequence MSRSVLQPSQQKLAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLALYYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASDREYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEYLSLDAMEKWIIFGFILCHGILNTDATALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAVSHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKSADDFIDKHIAELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGMRLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYSIAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSKKQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMYNQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIAYFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDKPDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAGLPCEIDPALVVALSSQKSENISPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTIHKGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQSVTSSA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSRSVLQPS
------CCCCCCCHH		44.5619413330
4Phosphorylation----MSRSVLQPSQQ
----CCCCCCCHHHH		36.1517855441
4 (in isoform 2)Phosphorylation-36.1527251275
9PhosphorylationSRSVLQPSQQKLAEK
CCCCCCHHHHHHHHH		32.0824043423
12UbiquitinationVLQPSQQKLAEKLTI
CCCHHHHHHHHHHHH		41.8723000965
12 (in isoform 1)Ubiquitination-41.8721890473
12 (in isoform 2)Ubiquitination-41.8721890473
16UbiquitinationSQQKLAEKLTILNDR
HHHHHHHHHHHHHHC		45.3723000965
16 (in isoform 1)Ubiquitination-45.3721890473
16 (in isoform 2)Ubiquitination-45.3721890473
18PhosphorylationQKLAEKLTILNDRGV
HHHHHHHHHHHHCCH		34.1930576142
23MethylationKLTILNDRGVGMLTR
HHHHHHHCCHHHHHH		40.39115484569
29PhosphorylationDRGVGMLTRLYNIKK
HCCHHHHHHHHHHHH		15.1017855441
35UbiquitinationLTRLYNIKKACGDPK
HHHHHHHHHHHCCCC		30.5832015554
46PhosphorylationGDPKAKPSYLIDKNL
CCCCCCHHHHCCCCH		31.6829083192
47PhosphorylationDPKAKPSYLIDKNLE
CCCCCHHHHCCCCHH		19.0629083192
51UbiquitinationKPSYLIDKNLESAVK
CHHHHCCCCHHHHHH		57.3432015554
57UbiquitinationDKNLESAVKFIVRKF
CCCHHHHHHHHHHHC		7.8732015554
58UbiquitinationKNLESAVKFIVRKFP
CCHHHHHHHHHHHCC		29.1422817900
58 (in isoform 1)Ubiquitination-29.1421890473
63MalonylationAVKFIVRKFPAVETR
HHHHHHHHCCCHHCC		44.8226320211
63UbiquitinationAVKFIVRKFPAVETR
HHHHHHHHCCCHHCC		44.8222817900
64UbiquitinationVKFIVRKFPAVETRN
HHHHHHHCCCHHCCC		3.0933845483
64 (in isoform 2)Ubiquitination-3.0921890473
69UbiquitinationRKFPAVETRNNNQQL
HHCCCHHCCCCHHHH		31.9022817900
81UbiquitinationQQLAQLQKEKSEILK
HHHHHHHHHHHHHHH		75.5821906983
81 (in isoform 1)Ubiquitination-75.5821890473
87UbiquitinationQKEKSEILKNLALYY
HHHHHHHHHHHHHHH		2.3632015554
87 (in isoform 2)Ubiquitination-2.3621890473
96PhosphorylationNLALYYFTFVDVMEF
HHHHHHHHHHHHHHH		13.46-
133PhosphorylationNFDLTKNYLDLIITY
CCCCCCCHHHHHHHH		11.8025867546
139PhosphorylationNYLDLIITYTTLMIL
CHHHHHHHHHHHHHH		14.0725867546
140PhosphorylationYLDLIITYTTLMILL
HHHHHHHHHHHHHHH		6.3125867546
141PhosphorylationLDLIITYTTLMILLS
HHHHHHHHHHHHHHH		12.5625867546
142PhosphorylationDLIITYTTLMILLSR
HHHHHHHHHHHHHHH		12.1525867546
148PhosphorylationTTLMILLSRIEERKA
HHHHHHHHHHHHHHH		27.9725867546
171PhosphorylationHEMTHGASDREYPRL
HHHCCCCCCCCCCCH		41.6217855441
175PhosphorylationHGASDREYPRLGQMI
CCCCCCCCCCHHHHH		8.44-
190UbiquitinationVDYENPLKKMMEEFV
HCCCCHHHHHHHHHC		39.621906983
190 (in isoform 1)Ubiquitination-39.6221890473
196 (in isoform 2)Ubiquitination-7.0721890473
201AcetylationEEFVPHSKSLSDALI
HHHCCCCCCHHHHHH		53.0019823111
294PhosphorylationLQSSSCLSLFRDEVF
HHCCHHHHHHHHHHH		29.7724719451
337PhosphorylationAAVSHAGSMHRERRK
HHHHHCCHHHHHHHH		16.5223312004
351UbiquitinationKFLRSALKELATVLS
HHHHHHHHHHHHHHC		50.8521906983
351 (in isoform 1)Ubiquitination-50.8521890473
357UbiquitinationLKELATVLSDQPGLL
HHHHHHHHCCCCCCC		3.9730230243
357 (in isoform 2)Ubiquitination-3.9721890473
392SulfoxidationLLRHADNMPKKSADD
HHHCHHCCCCCCHHH		5.4630846556
395UbiquitinationHADNMPKKSADDFID
CHHCCCCCCHHHHHH		45.0333845483
401UbiquitinationKKSADDFIDKHIAEL
CCCHHHHHHHHHHHH		9.9233845483
430PhosphorylationGPVMQRYYVQYLSGF
CHHHHHHHHHHHCCC		5.3522210691
469PhosphorylationSFVNTMTSLSVKQVE
HHCHHCCCCEEEECC		14.0724719451
499UbiquitinationRLQAYTSVSKASLGL
HHHHHHHCCHHHHCC		5.4023000965
501UbiquitinationQAYTSVSKASLGLAD
HHHHHCCHHHHCCCC		39.5823000965
505UbiquitinationSVSKASLGLADHREL
HCCHHHHCCCCHHHH		19.1423000965
507UbiquitinationSKASLGLADHRELGK
CHHHHCCCCHHHHHH		14.5723000965
507 (in isoform 2)Ubiquitination-14.57-
528PhosphorylationFHTKMVDSLVEMLVE
HHHHHHHHHHHHHHH		23.93-
549UbiquitinationFCFYSRAFEKMFQQC
HHHHHHHHHHHHHHH		10.1023000965
551UbiquitinationFYSRAFEKMFQQCLE
HHHHHHHHHHHHHHC		38.2623000965
555UbiquitinationAFEKMFQQCLELPSQ
HHHHHHHHHHCCCCC		23.6223000965
557UbiquitinationEKMFQQCLELPSQSR
HHHHHHHHCCCCCCC		7.0523000965
557 (in isoform 2)Ubiquitination-7.05-
561PhosphorylationQQCLELPSQSRYSIA
HHHHCCCCCCCCCHH		54.1129083192
563PhosphorylationCLELPSQSRYSIAFP
HHCCCCCCCCCHHHH		37.2129083192
595PhosphorylationRHHIGDRSLSLCNMF
HCCCCHHHHHHHHHH		27.3528348404
597PhosphorylationHIGDRSLSLCNMFLD
CCCHHHHHHHHHHHH		31.9328348404
599GlutathionylationGDRSLSLCNMFLDEM
CHHHHHHHHHHHHHH		2.8922555962
635UbiquitinationLLPKHCAKTISQAVN
CCHHHHHHHHHHHHH		52.3529967540
638PhosphorylationKHCAKTISQAVNKKS
HHHHHHHHHHHHHHH		19.8117494752
641UbiquitinationAKTISQAVNKKSKKQ
HHHHHHHHHHHHHHC		9.2829967540
643UbiquitinationTISQAVNKKSKKQTG
HHHHHHHHHHHHCCC		52.40-
644UbiquitinationISQAVNKKSKKQTGK
HHHHHHHHHHHCCCC		63.40-
645PhosphorylationSQAVNKKSKKQTGKK
HHHHHHHHHHCCCCC		46.8524719451
651UbiquitinationKSKKQTGKKGEPERE
HHHHCCCCCCCCCCC		62.08-
651 (in isoform 2)Phosphorylation-62.0824719451
664PhosphorylationREKPGVESMRKNRLV
CCCCCHHHHHHCCEE		22.8324719451
670 (in isoform 2)Phosphorylation-5.1924719451
691PhosphorylationELCFSINYVPNMVVW
HHHHHCCCCCCEEEE		18.66-
719PhosphorylationLEIRFTKSIVGMTMY
CEEEECHHHHHHHHH		21.3224275569
726PhosphorylationSIVGMTMYNQATQEI
HHHHHHHHHHHHHHH		8.5824719451
730PhosphorylationMTMYNQATQEIAKPS
HHHHHHHHHHHHCHH		19.5720068231
801PhosphorylationETLLRQVSNGHIAYF
HHHHHHHHCCCCCCC		28.8420068231
807PhosphorylationVSNGHIAYFPAMKAF
HHCCCCCCCCCCCHH		14.9720068231
838PhosphorylationSDISEMRSLSELLGP
CCHHHHHHHHHHHHH		34.63-
840PhosphorylationISEMRSLSELLGPYG
HHHHHHHHHHHHHHH		27.69-
852PhosphorylationPYGMKFLSESLMWHI
HHHHHHHHHHHHHHH		28.42-
880SulfoxidationNVDVLTQMRTSFDKP
CHHHHHHHCCCCCCH		4.2030846556
884UbiquitinationLTQMRTSFDKPDQMA
HHHHCCCCCCHHHHH		16.1123000965
886UbiquitinationQMRTSFDKPDQMAAL
HHCCCCCCHHHHHHH		48.7823000965
890UbiquitinationSFDKPDQMAALFKRL
CCCCHHHHHHHHHHH		2.8423000965
892UbiquitinationDKPDQMAALFKRLSS
CCHHHHHHHHHHHHC		14.2723000965
892 (in isoform 2)Ubiquitination-14.27-
893UbiquitinationKPDQMAALFKRLSSV
CHHHHHHHHHHHHCH		3.6421890473
895UbiquitinationDQMAALFKRLSSVDS
HHHHHHHHHHHCHHH		53.9621890473
895 (in isoform 1)Ubiquitination-53.9621890473
899PhosphorylationALFKRLSSVDSVLKR
HHHHHHHCHHHHHHH		34.2421406692
899UbiquitinationALFKRLSSVDSVLKR
HHHHHHHCHHHHHHH		34.2421890473
901UbiquitinationFKRLSSVDSVLKRMT
HHHHHCHHHHHHHHH		34.6721890473
901 (in isoform 2)Ubiquitination-34.6721890473
902PhosphorylationKRLSSVDSVLKRMTI
HHHHCHHHHHHHHHH		27.4821406692
908PhosphorylationDSVLKRMTIIGVILS
HHHHHHHHHHHHHHH		17.30-
943UbiquitinationVSSIEDFKDHIPRET
HHCHHHHHHHCCCCC		61.8033845483
949UbiquitinationFKDHIPRETDMKVAM
HHHHCCCCCCHHHHH		43.7533845483
1045PhosphorylationQIAAALFTIHKGSIE
HHHHHHHHHCCCCHH		24.03-
1050PhosphorylationLFTIHKGSIEDRLKE
HHHHCCCCHHHHHHH		27.8417855441
1065PhosphorylationFLALASSSLLKIGQE
HHHHHHHHHHHHCCC		34.9117855441
1075UbiquitinationKIGQETDKTTTRNRE
HHCCCCCCCCCCCHH		56.0133845483
1075 (in isoform 1)Ubiquitination-56.0121890473
1081UbiquitinationDKTTTRNRESVYLLL
CCCCCCCHHHHHHHH		33.9933845483
1081 (in isoform 2)Ubiquitination-33.9921890473
1116PhosphorylationYVLLRNAYHAVYKQS
HHHHHHHHHHHHHHH		8.2118083107
1119UbiquitinationLRNAYHAVYKQSVTS
HHHHHHHHHHHHHCC		3.8027667366
1120PhosphorylationRNAYHAVYKQSVTSS
HHHHHHHHHHHHCCC		12.2318083107
1121UbiquitinationNAYHAVYKQSVTSSA
HHHHHHHHHHHCCCC		29.5127667366
1123PhosphorylationYHAVYKQSVTSSA--
HHHHHHHHHCCCC--		24.1824043423
1125PhosphorylationAVYKQSVTSSA----
HHHHHHHCCCC----		23.3924043423
1125UbiquitinationAVYKQSVTSSA----
HHHHHHHCCCC----		23.3927667366
1126O-linked_GlycosylationVYKQSVTSSA-----
HHHHHHCCCC-----		23.3223301498
1126PhosphorylationVYKQSVTSSA-----
HHHHHHCCCC-----		23.3224043423
1127PhosphorylationYKQSVTSSA------
HHHHHCCCC------		28.7324043423
1127UbiquitinationYKQSVTSSA------
HHHHHCCCC------		28.7327667366
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NCKP1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NCKP1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NCKP1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ABI1_HUMANABI1physical
11418237
BRK1_HUMANBRK1physical
22863883
CYFP1_HUMANCYFIP1physical
26344197
CYFP2_HUMANCYFIP2physical
26344197
ERF1_HUMANETF1physical
26344197
WASF1_HUMANWASF1physical
26344197
WASF2_HUMANWASF2physical
26344197
ABI1_HUMANABI1physical
27173435
NXN_HUMANNXNphysical
27173435
CYFP1_HUMANCYFIP1physical
27173435
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NCKP1_HUMAN

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Related Literatures of Post-Translational Modification

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