WASF2_HUMAN - dbPTM
WASF2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WASF2_HUMAN
UniProt AC Q9Y6W5
Protein Name Wiskott-Aldrich syndrome protein family member 2
Gene Name WASF2 {ECO:0000312|HGNC:HGNC:12733}
Organism Homo sapiens (Human).
Sequence Length 498
Subcellular Localization Cytoplasm, cytoskeleton. Cell projection, lamellipodium. At the interface between the lamellipodial actin meshwork and the membrane..
Protein Description Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex..
Protein Sequence MPLVTRNIEPRHLCRQTLPSVRSELECVTNITLANVIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRLQVKVTQLDPKEEEVSLQGINTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDPSYFFDLWKEKMLQDTKDIMKEKRKHRKEKKDNPNRGNVNPRKIKTRKEEWEKMKMGQEFVESKEKLGTSGYPPTLVYQNGSIGCVENVDASSYPPPPQSDSASSPSPSFSEDNLPPPPAEFSYPVDNQRGSGLAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQPAIPPPLSDTTKPKSSLPAVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVATILSRRIAVEYSDSEDDSSEFDEDDWSD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
17PhosphorylationPRHLCRQTLPSVRSE
HHHHHHHCCHHHHHH		22.68-
27GlutathionylationSVRSELECVTNITLA
HHHHHHHHHHHHHHH		7.7522555962
46PhosphorylationQLGSLSKYAEDIFGE
HHHCHHHHHHHHHHH		16.3118083107
80PhosphorylationDRLQVKVTQLDPKEE
HHHEEEEEECCCCCC		20.0720068231
85UbiquitinationKVTQLDPKEEEVSLQ
EEEECCCCCCCCCCC		76.9329967540
90PhosphorylationDPKEEEVSLQGINTR
CCCCCCCCCCCCCHH		20.4628857561
102PhosphorylationNTRKAFRSSTIQDQK
CHHHHHHCCCCCCCC		25.9423401153
103PhosphorylationTRKAFRSSTIQDQKL
HHHHHHCCCCCCCCC		25.8527794612
104PhosphorylationRKAFRSSTIQDQKLF
HHHHHCCCCCCCCCC		24.7323403867
109UbiquitinationSSTIQDQKLFDRNSL
CCCCCCCCCCCCCCC		60.4524816145
115PhosphorylationQKLFDRNSLPVPVLE
CCCCCCCCCCCCEEE		34.6429978859
123PhosphorylationLPVPVLETYNTCDTP
CCCCEEEECCCCCCC		20.2228450419
124PhosphorylationPVPVLETYNTCDTPP
CCCEEEECCCCCCCC		10.0928450419
126PhosphorylationPVLETYNTCDTPPPL
CEEEECCCCCCCCCC		11.0126657352
129PhosphorylationETYNTCDTPPPLNNL
EECCCCCCCCCCCCC		39.5825159151
137PhosphorylationPPPLNNLTPYRDDGK
CCCCCCCCCCCCCCH		22.0128450419
139PhosphorylationPLNNLTPYRDDGKEA
CCCCCCCCCCCCHHH		22.8028450419
150PhosphorylationGKEALKFYTDPSYFF
CHHHHHHHCCHHHHH		14.5115657136
155PhosphorylationKFYTDPSYFFDLWKE
HHHCCHHHHHHHHHH		17.4120736484
161UbiquitinationSYFFDLWKEKMLQDT
HHHHHHHHHHHHHHH		55.5421906983
163UbiquitinationFFDLWKEKMLQDTKD
HHHHHHHHHHHHHHH		40.9822817900
168PhosphorylationKEKMLQDTKDIMKEK
HHHHHHHHHHHHHHH		20.04-
169AcetylationEKMLQDTKDIMKEKR
HHHHHHHHHHHHHHH		54.2523236377
169UbiquitinationEKMLQDTKDIMKEKR
HHHHHHHHHHHHHHH		54.25-
183UbiquitinationRKHRKEKKDNPNRGN
HHHHHHHCCCCCCCC		64.9224816145
215PhosphorylationMGQEFVESKEKLGTS
HHHHHHHHHHHHCCC		40.5928985074
216UbiquitinationGQEFVESKEKLGTSG
HHHHHHHHHHHCCCC		45.4121906983
230PhosphorylationGYPPTLVYQNGSIGC
CCCCEEEEECCCEEE		10.20-
257PhosphorylationPQSDSASSPSPSFSE
CCCCCCCCCCCCCCC		29.1619917258
259PhosphorylationSDSASSPSPSFSEDN
CCCCCCCCCCCCCCC		34.8119917258
284PhosphorylationPVDNQRGSGLAGPKR
CCCCCCCCCCCCCCC		32.5930266825
292PhosphorylationGLAGPKRSSVVSPSH
CCCCCCCCCCCCCCC		33.3429255136
293PhosphorylationLAGPKRSSVVSPSHP
CCCCCCCCCCCCCCC		30.4829255136
296PhosphorylationPKRSSVVSPSHPPPA
CCCCCCCCCCCCCCC		20.6629255136
298PhosphorylationRSSVVSPSHPPPAPP
CCCCCCCCCCCCCCC		40.9129255136
308PhosphorylationPPAPPLGSPPGPKPG
CCCCCCCCCCCCCCC		35.2920164059
343PhosphorylationPPPVGFGSPGTPPPP
CCCCCCCCCCCCCCC		20.2121419341
346PhosphorylationVGFGSPGTPPPPSPP
CCCCCCCCCCCCCCC		35.6921419341
351PhosphorylationPGTPPPPSPPSFPPH
CCCCCCCCCCCCCCC		56.0421419341
427UbiquitinationLSDTTKPKSSLPAVS
CCCCCCCCCCCCCCH		54.9933845483
428PhosphorylationSDTTKPKSSLPAVSD
CCCCCCCCCCCCCHH		45.7123403867
429PhosphorylationDTTKPKSSLPAVSDA
CCCCCCCCCCCCHHH		44.4923403867
434PhosphorylationKSSLPAVSDARSDLL
CCCCCCCHHHHHHHH		27.8823403867
438PhosphorylationPAVSDARSDLLSAIR
CCCHHHHHHHHHHHH		34.0423403867
442PhosphorylationDARSDLLSAIRQGFQ
HHHHHHHHHHHHHHH		29.0125850435
471PhosphorylationVVGNDVATILSRRIA
CCCHHHHHHHHCEEE		23.4629255136
474PhosphorylationNDVATILSRRIAVEY
HHHHHHHHCEEEEEC		18.7029255136
481PhosphorylationSRRIAVEYSDSEDDS
HCEEEEECCCCCCCC		15.92-
482PhosphorylationRRIAVEYSDSEDDSS
CEEEEECCCCCCCCC		22.5825137130
484PhosphorylationIAVEYSDSEDDSSEF
EEEECCCCCCCCCCC		36.6625137130
488PhosphorylationYSDSEDDSSEFDEDD
CCCCCCCCCCCCCCC		44.0525137130
489PhosphorylationSDSEDDSSEFDEDDW
CCCCCCCCCCCCCCC		49.6425137130
497PhosphorylationEFDEDDWSD------
CCCCCCCCC------		40.2025137130
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
150YPhosphorylationKinaseABL1P00519
PhosphoELM
150YPhosphorylationKinaseABL-FAMILY-GPS
296SPhosphorylationKinaseMAPK1P28482
GPS
308SPhosphorylationKinaseMAPK1P28482
GPS
343SPhosphorylationKinaseMAPK3P27361
GPS
346TPhosphorylationKinaseMAPK3P27361
GPS
351SPhosphorylationKinaseMAPK3P27361
GPS
482SPhosphorylationKinaseCSNK2A1P68400
GPS
484SPhosphorylationKinaseCSNK2A1P68400
GPS
488SPhosphorylationKinaseCSNK2A1P68400
GPS
489SPhosphorylationKinaseCSNK2A1P68400
GPS
497SPhosphorylationKinaseCSNK2A1P68400
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WASF2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WASF2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
ARP3_HUMANACTR3physical
10381382
BAIP2_HUMANBAIAP2physical
11130076
WASL_HUMANWASLphysical
22939629
DPOD1_HUMANPOLD1physical
22863883
ABI3_HUMANABI3physical
17101133
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WASF2_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-482; SER-484; SER-488AND SER-489, AND MASS SPECTROMETRY.

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