ABI3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABI3_HUMAN
• UniProt AC: Q9P2A4
• Protein Name: ABI gene family member 3
• Gene Name: ABI3
• Organism: Homo sapiens (Human).
• Sequence Length: 366
• Subcellular Localization: Cytoplasm . Colocalizes with PAK2 at leading edge of cells.
• Protein Description: May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility..
• Protein Sequence: MAELQQLQEFEIPTGREALRGNHSALLRVADYCEDNYVQATDKRKALEETMAFTTQALASVAYQVGNLAGHTLRMLDLQGAALRQVEARVSTLGQMVNMHMEKVARREIGTLATVQRLPPGQKVIAPENLPPLTPYCRRPLNFGCLDDIGHGIKDLSTQLSRTGTLSRKSIKAPATPASATLGRPPRIPEPVHLPVVPDGRLSAASSAFSLASAGSAEGVGGAPTPKGQAAPPAPPLPSSLDPPPPPAAVEVFQRPPTLEELSPPPPDEELPLPLDLPPPPPLDGDELGLPPPPPGFGPDEPSWVPASYLEKVVTLYPYTSQKDNELSFSEGTVICVTRRYSDGWCEGVSSEGTGFFPGNYVEPSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
24	Phosphorylation	EALRGNHSALLRVAD HHHCCCCHHHHHHHH	25.31	28348404
43	Ubiquitination	NYVQATDKRKALEET CCEECCHHHHHHHHH	51.98	-
134	Phosphorylation	PENLPPLTPYCRRPL CCCCCCCCCCCCCCC	20.27	23403867
136	Phosphorylation	NLPPLTPYCRRPLNF CCCCCCCCCCCCCCC	8.05	23403867
157	Phosphorylation	GHGIKDLSTQLSRTG CCHHHHHHHHHHHCC	25.00	23403867
158	Phosphorylation	HGIKDLSTQLSRTGT CHHHHHHHHHHHCCC	40.61	23403867
161	Phosphorylation	KDLSTQLSRTGTLSR HHHHHHHHHCCCCCH	20.27	23403867
163	Phosphorylation	LSTQLSRTGTLSRKS HHHHHHHCCCCCHHH	31.01	23403867
165	Phosphorylation	TQLSRTGTLSRKSIK HHHHHCCCCCHHHCC	22.43	23403867
167	Phosphorylation	LSRTGTLSRKSIKAP HHHCCCCCHHHCCCC	37.18	23403867
170	Phosphorylation	TGTLSRKSIKAPATP CCCCCHHHCCCCCCC	28.36	9871865
179	Phosphorylation	KAPATPASATLGRPP CCCCCCCCCCCCCCC	24.00	23684312
181	Phosphorylation	PATPASATLGRPPRI CCCCCCCCCCCCCCC	27.53	23684312
207	Phosphorylation	GRLSAASSAFSLASA CCCHHHHHHHHHHHC	28.71	27251275
210	Phosphorylation	SAASSAFSLASAGSA HHHHHHHHHHHCCCC	23.81	46108197
213	Phosphorylation	SSAFSLASAGSAEGV HHHHHHHHCCCCCCC	38.16	24275569
216	Phosphorylation	FSLASAGSAEGVGGA HHHHHCCCCCCCCCC	23.90	20166139
258	Phosphorylation	EVFQRPPTLEELSPP HHCCCCCCHHHHCCC	49.86	118091
263	Phosphorylation	PPTLEELSPPPPDEE CCCHHHHCCCCCCCC	38.34	69013407
338	Phosphorylation	EGTVICVTRRYSDGW CCEEEEEEEECCCCC	12.67	50558757
341	Phosphorylation	VICVTRRYSDGWCEG EEEEEEECCCCCEEC	14.07	28450419
342	Phosphorylation	ICVTRRYSDGWCEGV EEEEEECCCCCEECC	28.03	20058876
350	Phosphorylation	DGWCEGVSSEGTGFF CCCEECCCCCCCCCC	33.26	28450419
351	Phosphorylation	GWCEGVSSEGTGFFP CCEECCCCCCCCCCC	37.32	27251275
365	Phosphorylation	PGNYVEPSC------ CCCCCCCCC------	20.96	50558763

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	WWP2	O00308	PMID:15998807

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABI3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
210	Phosphorylation	203;209 (7;1)	S ⇒ F	rs616338	Alzheimer's disease (late onset)	28714976
213	Phosphorylation	203;209 (10;4)	S ⇒ F	rs616338	Alzheimer's disease (late onset)	28714976
216	Phosphorylation	209 (7)	S ⇒ F	rs616338	Alzheimer's disease (late onset)	28714976

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TARSH_HUMAN	ABI3BP	physical	11501947
DTBP1_HUMAN	DTNBP1	physical	16189514
CEP44_HUMAN	CEP44	physical	16189514
PAK1_HUMAN	PAK1	physical	11956071
PAK2_HUMAN	PAK2	physical	11956071
ABI3_HUMAN	ABI3	physical	25416956
EVL_HUMAN	EVL	physical	25416956
ARMC7_HUMAN	ARMC7	physical	25416956
CEP44_HUMAN	CEP44	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
KLC4_HUMAN	KLC4	physical	25416956
MR1L1_HUMAN	MRFAP1L1	physical	25416956
KLC3_HUMAN	KLC3	physical	25416956
ENAH_HUMAN	ENAH	physical	17101133
WASF2_HUMAN	WASF2	physical	17101133
WASP_HUMAN	WAS	physical	21516116
NUP58_HUMAN	NUPL1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.