TARSH_HUMAN - dbPTM
TARSH_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TARSH_HUMAN
UniProt AC Q7Z7G0
Protein Name Target of Nesh-SH3
Gene Name ABI3BP
Organism Homo sapiens (Human).
Sequence Length 1075
Subcellular Localization Secreted .
Protein Description
Protein Sequence MRGGKCNMLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSPNVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGKTRSRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWIFQICPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTVVGSKKVNGKIQSTYDQDHTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLPASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSALDVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDRILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKRRPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTKPAPKQTPRAPPKPKTSPRPRIPQTQPVPKVPQRVTAKPKTSPSPEVSYTTPAPKDVLLPHKPYPEVSQSEPAPLETRGIPFIPMISPSPSQEELQTTLEETDQSTQEPFTTKIPRTTELAKTTQAPHRFYTTVRPRTSDKPHIRPGVKQAPRPSGADRNVSVDSTHPTKKPGTRRPPLPPRPTHPRRKPLPPNNVTGKPGSAGIISSGPITTPPLRSTPRPTGTPLERIETDIKQPTVPASGEELENITDFSSSPTRETDPLGKPRFKGPHVRYIQKPDNSPCSITDSVKRFPKEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWEKPLNDTVTEYEVISRENGSFSGKNKSIQMTNQTFSTVENLKPNTSYEFQVKPKNPLGEGPVSNTVAFSTESADPRVSEPVSAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVGVQLCNSLRYKIYLSDSLTGKFYNIGDQRGHGEDHCQFVDSFLDGRTGQQLTSDQLPIKEGYFRAVRQEPVQFGEIGGHTQINYVQWYECGTTIPGKW
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
44N-linked_GlycosylationPNLKVHINTTSDSIL
CCCEEEEECCCCCHH		23.5619159218
55 (in isoform 2)Phosphorylation-8.2222210691
68 (in isoform 2)Phosphorylation-6.2922210691
69 (in isoform 2)Phosphorylation-25.4022210691
72 (in isoform 2)Phosphorylation-26.1021955146
99PhosphorylationIVDAEPKYLIVVRPA
EECCCCCEEEEEECC		16.6328111955
110PhosphorylationVRPAPPPSQKKSCSG
EECCCCCCCCCCCCC		61.4828111955
116PhosphorylationPSQKKSCSGKTRSRK
CCCCCCCCCCCCCCC		50.8750558775
143 (in isoform 4)Phosphorylation-5.1430631047
164PhosphorylationCPNDRFYTIRYREKD
CCCCCEEEEEEECCC		9.0324719451
185 (in isoform 4)Phosphorylation-38.3522496350
203 (in isoform 4)Phosphorylation-63.10-
218PhosphorylationSKIFNHKTVVGSKKV
HHHHCCCEEECCEEE		16.9323312004
222PhosphorylationNHKTVVGSKKVNGKI
CCCEEECCEEECCEE		20.0723312004
224 (in isoform 3)Phosphorylation-42.5022210691
237 (in isoform 3)Phosphorylation-24.1122210691
238 (in isoform 3)Phosphorylation-36.1522210691
238O-linked_GlycosylationSTYDQDHTVPAYVPR
ECCCCCCCCCCCCCC		36.15OGP
241 (in isoform 3)Phosphorylation-17.3921955146
251PhosphorylationPRKLIPITIIKQVIQ
CCCHHCHHHHHHHHH		15.9945553611
335O-linked_GlycosylationEKISARPTTVTPETV
EEEECCCCCCCCCCC		28.48OGP
353 (in isoform 4)Phosphorylation-13.9322210691
366 (in isoform 4)Phosphorylation-47.8322210691
367 (in isoform 4)Phosphorylation-23.2122210691
370 (in isoform 4)Phosphorylation-2.8121955146
417PhosphorylationTSDRILDSIPPKTSR
CCCHHHHCCCCCCCC		33.2850558769
425PhosphorylationIPPKTSRTLEQPRAT
CCCCCCCCCCCCCCC		34.1246157139
436PhosphorylationPRATLAPSETPFVPQ
CCCCCCCCCCCCCCC		48.7922210691
438O-linked_GlycosylationATLAPSETPFVPQKL
CCCCCCCCCCCCCEE		26.77OGP
468PhosphorylationQQTTSIPSTPKRRPR
CCCCCCCCCCCCCCC		56.5220363803
469PhosphorylationQTTSIPSTPKRRPRP
CCCCCCCCCCCCCCC		27.7228060719
488PhosphorylationTKPERTTSAGTITPK
CCCCCCCCCCEECCC		24.8823911959
491PhosphorylationERTTSAGTITPKISK
CCCCCCCEECCCCCC		22.7623911959
493PhosphorylationTTSAGTITPKISKSP
CCCCCEECCCCCCCC		20.5446157145
497PhosphorylationGTITPKISKSPEPTW
CEECCCCCCCCCCCC		32.9646157135
571PhosphorylationRVTAKPKTSPSPEVS
CCCCCCCCCCCCCCC		55.1626074081
572PhosphorylationVTAKPKTSPSPEVSY
CCCCCCCCCCCCCCC		29.5226074081
574PhosphorylationAKPKTSPSPEVSYTT
CCCCCCCCCCCCCCC		33.2026074081
578PhosphorylationTSPSPEVSYTTPAPK
CCCCCCCCCCCCCCC		18.3326074081
579PhosphorylationSPSPEVSYTTPAPKD
CCCCCCCCCCCCCCC		21.5826074081
580PhosphorylationPSPEVSYTTPAPKDV
CCCCCCCCCCCCCCC		20.8526074081
581PhosphorylationSPEVSYTTPAPKDVL
CCCCCCCCCCCCCCC		14.8226074081
600O-linked_GlycosylationPYPEVSQSEPAPLET
CCCCCCCCCCCCCCC		37.73OGP
617O-linked_GlycosylationIPFIPMISPSPSQEE
CCEEEECCCCCCHHH		17.05OGP
692PhosphorylationSGADRNVSVDSTHPT
CCCCCCCCCCCCCCC		24.6110486953
695PhosphorylationDRNVSVDSTHPTKKP
CCCCCCCCCCCCCCC		26.8510486965
696PhosphorylationRNVSVDSTHPTKKPG
CCCCCCCCCCCCCCC		27.6610486977
753O-linked_GlycosylationLRSTPRPTGTPLERI
CCCCCCCCCCCHHHE		55.77OGP
762PhosphorylationTPLERIETDIKQPTV
CCHHHEECCCCCCCC		40.4226657352
768PhosphorylationETDIKQPTVPASGEE
ECCCCCCCCCCCHHH		36.3126657352
768O-linked_GlycosylationETDIKQPTVPASGEE
ECCCCCCCCCCCHHH		36.31OGP
772PhosphorylationKQPTVPASGEELENI
CCCCCCCCHHHHHCC		40.4426657352
787O-linked_GlycosylationTDFSSSPTRETDPLG
CCCCCCCCCCCCCCC		42.98OGP
967PhosphorylationSECKGKQYVKRTWYK
HHHCCCHHHHHHHHH		16.0726074081
971PhosphorylationGKQYVKRTWYKKFVG
CCHHHHHHHHHHCHH		27.6826074081
973PhosphorylationQYVKRTWYKKFVGVQ
HHHHHHHHHHCHHHH		12.0426074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TARSH_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TARSH_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TARSH_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AATC_HUMANGOT1physical
21988832
MBNL1_HUMANMBNL1physical
21988832
FZD5_HUMANFZD5physical
21988832
CBX1_HUMANCBX1physical
21988832
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TARSH_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Glycoproteomics analysis of human liver tissue by combination ofmultiple enzyme digestion and hydrazide chemistry.";
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
J. Proteome Res. 8:651-661(2009).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-44, AND MASS SPECTROMETRY.

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