FZD5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD5_HUMAN
• UniProt AC: Q13467
• Protein Name: Frizzled-5
• Gene Name: FZD5
• Organism: Homo sapiens (Human).
• Sequence Length: 585
• Subcellular Localization: Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell projection, axon . Localized at the plasma membrane and also found at the Go
• Protein Description: Receptor for Wnt proteins. [PubMed: 9054360]
• Protein Sequence: MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSEATTAPPRPFPAKPTLPGPPGAPASGGECPAGGPFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHNHIHYETTGPALCTIVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGHDTGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTVESWRRFTSRCCCRPRRGHKSGGAMAAGDYPEASAALTGRTGPPGPAATYHKQVSLSHV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MARPDPSAPPSLLL -CCCCCCCCCHHHHH	61.87	-
11	Phosphorylation	PDPSAPPSLLLLLLA CCCCCCHHHHHHHHH	30.50	-
47	N-linked_Glycosylation	MCRGIGYNLTHMPNQ CCCCCCCCCCCCCCC	33.00	28377511
151	N-linked_Glycosylation	EVLCMDYNRSEATTA EEEEECCCCCCCCCC	36.42	UniProtKB CARBOHYD
168	O-linked_Glycosylation	RPFPAKPTLPGPPGA CCCCCCCCCCCCCCC	44.90	OGP
178	O-linked_Glycosylation	GPPGAPASGGECPAG CCCCCCCCCCCCCCC	46.39	OGP
440	Phosphorylation	IKQGGTKTDKLEKLM HHCCCCCCHHHHHHH	37.90	-
547	Phosphorylation	RPRRGHKSGGAMAAG CCCCCCCCCCCCCCC	36.46	22210691
556	Phosphorylation	GAMAAGDYPEASAAL CCCCCCCCHHHHHHH	11.31	22817900
575	Phosphorylation	GPPGPAATYHKQVSL CCCCCCCEECCCEEC	28.41	25884760
576	Phosphorylation	PPGPAATYHKQVSLS CCCCCCEECCCEECC	11.42	28152594
578	Ubiquitination	GPAATYHKQVSLSHV CCCCEECCCEECCCC	41.82	33845483
581	Phosphorylation	ATYHKQVSLSHV--- CEECCCEECCCC---	22.97	24719451
583	Phosphorylation	YHKQVSLSHV----- ECCCEECCCC-----	18.07	25072903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	RNF43	Q68DV7	PMID:22895187

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RGS2_HUMAN	RGS2	physical	21988832
LZTL1_HUMAN	LZTFL1	physical	21988832
UBTD1_HUMAN	UBTD1	physical	21988832
LRP6_HUMAN	LRP6	physical	12121999
RNF43_HUMAN	RNF43	physical	25825523
DVL2_HUMAN	DVL2	physical	25825523

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.