UBTD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBTD1_HUMAN
• UniProt AC: Q9HAC8
• Protein Name: Ubiquitin domain-containing protein 1
• Gene Name: UBTD1
• Organism: Homo sapiens (Human).
• Sequence Length: 227
• Protein Description: May be involved in the regulation of cellular senescence through a positive feedback loop with TP53. Is a TP53 downstream target gene that increases the stability of TP53 protein by promoting the ubiquitination and degradation of MDM2..
• Protein Sequence: MGNCVGRQRRERPAAPGHPRKRAGRNEPLKKERLKWKSDYPMTDGQLRSKRDEFWDTAPAFEGRKEIWDALKAAAYAAEANDHELAQAILDGASITLPHGTLCECYDELGNRYQLPIYCLSPPVNLLLEHTEEESLEPPEPPPSVRREFPLKVRLSTGKDVRLSASLPDTVGQLKRQLHAQEGIEPSWQRWFFSGKLLTDRTRLQETKIQKDFVIQVIINQPPPPQD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35	Ubiquitination	PLKKERLKWKSDYPM CCCHHHCCCCCCCCC	59.81	22817900
37	Ubiquitination	KKERLKWKSDYPMTD CHHHCCCCCCCCCCC	31.68	21890473
40	Phosphorylation	RLKWKSDYPMTDGQL HCCCCCCCCCCCCCH	11.29	-
43	Phosphorylation	WKSDYPMTDGQLRSK CCCCCCCCCCCHHCC	32.26	-
50	Ubiquitination	TDGQLRSKRDEFWDT CCCCHHCCCHHHHHC	58.39	23000965
65	Ubiquitination	APAFEGRKEIWDALK CCCCCCHHHHHHHHH	65.49	23000965
164	Phosphorylation	TGKDVRLSASLPDTV CCCCEEEECCCCCHH	12.78	30266825
166	Phosphorylation	KDVRLSASLPDTVGQ CCEEEECCCCCHHHH	36.74	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBTD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBTD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBTD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2D2_HUMAN	UBE2D2	physical	24211586
UB2D3_HUMAN	UBE2D3	physical	24211586
UB2D4_HUMAN	UBE2D4	physical	24211586
RNF10_HUMAN	RNF10	physical	24211586
TEAD1_HUMAN	TEAD1	physical	24211586
RBP2_HUMAN	RANBP2	physical	24211586
K2026_HUMAN	KIAA2026	physical	24211586
PFKAM_HUMAN	PFKM	physical	24211586
BCOR_HUMAN	BCOR	physical	24211586
UB2D1_HUMAN	UBE2D1	physical	24211586
SHRM3_HUMAN	SHROOM3	physical	24211586
MR1L1_HUMAN	MRFAP1L1	physical	25416956

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.