K2026_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2026_HUMAN
• UniProt AC: Q5HYC2
• Protein Name: Uncharacterized protein KIAA2026
• Gene Name: KIAA2026
• Organism: Homo sapiens (Human).
• Sequence Length: 2103
• Protein Sequence: MSVPGTPGAMEPAGEEERPPPAAEGEDDEEEVAAAAQTSGPAHGRSASSLEDADDQEEEMEAMVIGGGCCKEQELTYELQQGYRILGEFLQEKHRGLTAPFLQPLGGVATAEEEVAEGPRSGGRGGRAFPQQPGQGMCLLQMEEKFASGQYGGITEFVADFRLMLETCYRLHGVDHWISKQGQKLEMMLEQKLALLSRHLREKTTIAVTSRGYYGLEDEKGTACTSTRRRSTPRSLAGLTSGVFESIMVQVLRQEEQLRAKEEKRLREQERKEAEEASQKEIEEWERKLLAQAAPTCMETMWEIPAIGHFLCLAQQILNLPEIVFYELERCLLMPQCNAFLSKIMTSLLSPPHRRPTLHRRPTLPYRTWEAALRQKVQQWYTAVGQTENPDNCAEKLGLCPQFFKVLGEVNPLEEKPFHELPFYQKVWLLKGLCDFVYETQKEVQDAVLGQPIHECREVILGYDYLENAYVHFPQFCGADVRIYKQRPFQAPEFPIPPIKIQRVPRIKLEKLKCDYVSTSNGEHRCSRDSLPSSFKKEQENNFDPACCPAKMILDNHDISVEMGVKSNYEIRIRRPCEIKKTDCCKENLEKPRSPGEVTGFGEPLSPGEIRFIENQEKYGEASRIKIEPSPLKENTLKSCQIHVNGSHSDHPEINCHKVVRDILLEQSLQSHKKLKLTKMRAKKKKKKKKKLKDVLNENLQRKREGLHSLAFKSYKPEIQNKLLIIKKKAKHKKHKSGKKSVSKKAITKKRKTVIKSPTVPEFQLICTNLDELRELITKIENELKDLENSRKKSGKWYHRRQAVKELHSTLIRLLNELLPWEPKLMKAFQRNRSRLKKDYDDFRRQPDHDTFNRELWTTDEGEGDLGKDSPKGEISKSIDSTEPLDILEKDHFDSDDMKLSEIDFPMARSKLLKKELPSKDLPKTLLKTLKRQSKQTDYVDDSTKELSPRKKAKLSTNETTVENLESDVQIDCFSESKHTEPSFPESFASLDSVPVSTLQKGTKPIQALLAKNIGNKVTLTNQLPPSTGRNALAVEKPVLSPPEASPIKPALTCHTNTKGPLQMVYKMPCGQWLPIDLQNSSVKIQVQPMVDPKTGEKIMQQVLILPKNFVIQHKEGKAVAKEVPPLQQKGTEQHCSSFPQTTNINSSLASVFVNSPGTVSTQLPNTAFNKTITPLSNISSARPQPLSPVTSVSNLLTPSVKTSQSEAGKAKNAVSAATFSLPSASPTISSTGQPLSSTTTLNGSTNPGSSFNCFAQQTADSSEAKQELKTVCIRDSQSILVRTRGGNTGVVKVQTNPDQNSPNTVSSSSVFTFAPQLQAFLVPKSTTSSSAFSPVAGTTTTSSLSPFSQTPTSVSIPASFAPSMGKNLKLTLGHTTGSGDLGHVIDKTSHMPSSPLKSSICSSTLLPSTTSSSVSVISISAANFGQNNANIIHTPTKQQQVDYITKSYPVTRSEATAATNGDVISGTPVQKLMLVSAPSILSSGNGTAINMTPALTSTGVSAQKLVFINAPVPSGTSTPTLVAESLKQTLPPPLHKAYVKTPEQPQIVLIPSTVGTPIKINSSPAVSQIKDVKIGLNIGQAIVNTSGTVPAIPSINILQNVTPKGEDKSSKGYILPLSTSGNSVPVSSNFVSQNITPVNESVVSSARAVNVLSVTGANLSLGSFPVTSASASAGAQPPVLVSGNDTSSRIMPILSNRLCSSSLGNTVAISTVKTGHLASSVLISTTQPVVSPKCLTSALQIPVTVALPTPATTSPKIINTVPHSAAVPGATRSVSISKRQSRTSLQFHSPGISTTVPTNVNTNKPQTELSSLSTSPGKITNTSNFASLPNQQALVKTPSYSSAPGGTTIHTASAPSNVTSLVGSQFSEPCIQQKIVINTSTPLAPGTQIMINGTRFIVPPQGLGAGSHVLLISTNPKYGAPLVLNSGQGIQSTPIDNSAQKITLASNNSLSGQPLQHPLRSPTKFINSFGNASSIPTVHTSPQLINTTAKVPVPPPVPTVSLTSVIKSPATLLAKTSLVSAICPSNPPLPSSTSVFHLDPPVKKLLVSPEGAILNTINTPASKVSSLSPSLSQIVVSASRSPASVFPAFQSSGLEKPDRAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSVPGTPGA ------CCCCCCCCC	48.61	22210691
6	Phosphorylation	--MSVPGTPGAMEPA --CCCCCCCCCCCCC	16.69	22210691
204	Phosphorylation	SRHLREKTTIAVTSR HHHHHHCCEEEEECC	20.77	-
227	Phosphorylation	KGTACTSTRRRSTPR CCCCCCCCCCCCCCC	15.28	-
280	Ubiquitination	EAEEASQKEIEEWER HHHHHHHHHHHHHHH	59.15	-
346	Phosphorylation	AFLSKIMTSLLSPPH HHHHHHHHHHCCCCC	21.50	29978859
347	Phosphorylation	FLSKIMTSLLSPPHR HHHHHHHHHCCCCCC	15.21	29978859
350	Phosphorylation	KIMTSLLSPPHRRPT HHHHHHCCCCCCCCC	41.50	29978859
465	Phosphorylation	EVILGYDYLENAYVH HHHHCCHHHHCEEEC	13.87	-
470	Phosphorylation	YDYLENAYVHFPQFC CHHHHCEEECCCCCC	13.16	-
567	Phosphorylation	SVEMGVKSNYEIRIR EEEECCCCCCEEEEC	42.09	-
569	Phosphorylation	EMGVKSNYEIRIRRP EECCCCCCEEEECCC	21.59	-
594	Phosphorylation	ENLEKPRSPGEVTGF HCCCCCCCCCCCCCC	45.87	25850435
599	Phosphorylation	PRSPGEVTGFGEPLS CCCCCCCCCCCCCCC	23.61	22199227
606	Phosphorylation	TGFGEPLSPGEIRFI CCCCCCCCHHHEEEE	41.39	22199227
619	Phosphorylation	FIENQEKYGEASRIK EECCHHHHCCCCCCE	21.32	-
630	Phosphorylation	SRIKIEPSPLKENTL CCCEECCCCCCCCCC	30.03	23186163
636	Phosphorylation	PSPLKENTLKSCQIH CCCCCCCCCCCCEEE	36.33	23186163
668	Phosphorylation	RDILLEQSLQSHKKL HHHHHHHHHHHHHHH	20.99	28555341
671	Phosphorylation	LLEQSLQSHKKLKLT HHHHHHHHHHHHHHH	42.43	28555341
737	Phosphorylation	AKHKKHKSGKKSVSK HCCCCCCCCCCCCCH	56.41	21949786
778	Phosphorylation	DELRELITKIENELK HHHHHHHHHHHHHHH	38.30	29396449
790	Phosphorylation	ELKDLENSRKKSGKW HHHHHHHHHHHCCCH	35.78	22673903
851	Phosphorylation	RRQPDHDTFNRELWT HHCCCCCCCCCCEEE	21.27	24719451
870	Phosphorylation	EGDLGKDSPKGEISK CCCCCCCCCCCCCCC	31.81	24719451
878	Phosphorylation	PKGEISKSIDSTEPL CCCCCCCCCCCCCCC	25.49	28348404
910	Phosphorylation	IDFPMARSKLLKKEL CCCHHHHHHHHHHHC	20.37	23403867
919	Phosphorylation	LLKKELPSKDLPKTL HHHHHCCCCCCCHHH	51.96	24719451
919	O-linked_Glycosylation	LLKKELPSKDLPKTL HHHHHCCCCCCCHHH	51.96	30379171
943	Phosphorylation	QTDYVDDSTKELSPR CCCCCCCCCCCCCHH	36.59	-
948	Phosphorylation	DDSTKELSPRKKAKL CCCCCCCCHHHCCCC	24.61	22210691
1041	Phosphorylation	AVEKPVLSPPEASPI EEECCCCCCCCCCCC	38.35	27050516
1095	Phosphorylation	QPMVDPKTGEKIMQQ ECCCCCCCHHHHHHH	56.83	-
1302	Phosphorylation	QTNPDQNSPNTVSSS ECCCCCCCCCCCCCC	17.56	27251275
1305	Phosphorylation	PDQNSPNTVSSSSVF CCCCCCCCCCCCHHE	25.75	27251275
1313	Phosphorylation	VSSSSVFTFAPQLQA CCCCHHEECCCCCEE	19.41	24719451
1394	Phosphorylation	DKTSHMPSSPLKSSI ECCCCCCCCCCCCCC	36.69	28348404
1395	Phosphorylation	KTSHMPSSPLKSSIC CCCCCCCCCCCCCCC	28.51	28450419
1563	Phosphorylation	GTPIKINSSPAVSQI CCCEEECCCCCHHHC	40.97	23882029
1564	Phosphorylation	TPIKINSSPAVSQIK CCEEECCCCCHHHCC	16.64	23882029
1568	Phosphorylation	INSSPAVSQIKDVKI ECCCCCHHHCCEEEE	28.44	23882029
1603	Phosphorylation	INILQNVTPKGEDKS CEEEECCCCCCCCCC	27.17	20562096
1701	Phosphorylation	ILSNRLCSSSLGNTV HHCCCCCCCCCCCEE	27.79	22210691
1702	Phosphorylation	LSNRLCSSSLGNTVA HCCCCCCCCCCCEEE	28.69	30631047
1703	Phosphorylation	SNRLCSSSLGNTVAI CCCCCCCCCCCEEEE	24.81	-
1707	Phosphorylation	CSSSLGNTVAISTVK CCCCCCCEEEEEEEE	14.98	22210691
1712	Phosphorylation	GNTVAISTVKTGHLA CCEEEEEEEECCCCC	21.65	22210691
1737	Phosphorylation	VVSPKCLTSALQIPV CCCHHHHHHCCCCCE	22.79	24043423
1738	Phosphorylation	VSPKCLTSALQIPVT CCHHHHHHCCCCCEE	17.65	24043423
1745	Phosphorylation	SALQIPVTVALPTPA HCCCCCEEEECCCCC	8.49	24043423
1750	Phosphorylation	PVTVALPTPATTSPK CEEEECCCCCCCCCC	26.80	24043423
1753	Phosphorylation	VALPTPATTSPKIIN EECCCCCCCCCCEEC	29.07	24043423
1754	Phosphorylation	ALPTPATTSPKIINT ECCCCCCCCCCEECC	45.17	24043423
1755	Phosphorylation	LPTPATTSPKIINTV CCCCCCCCCCEECCC	21.60	24043423
1765	O-linked_Glycosylation	IINTVPHSAAVPGAT EECCCCHHCCCCCCC	16.32	30379171
1774	Phosphorylation	AVPGATRSVSISKRQ CCCCCCEEEEECCCC	18.83	26437602
1776	Phosphorylation	PGATRSVSISKRQSR CCCCEEEEECCCCCC	23.53	26437602
1808	Phosphorylation	VNTNKPQTELSSLST CCCCCCCCCHHHCCC	47.63	22210691
1824	Phosphorylation	PGKITNTSNFASLPN CCCCCCCCCCCCCCC	31.83	22210691
1962	Phosphorylation	PLQHPLRSPTKFINS CCCCCCCCCCCHHHC	44.60	26329039
1969	Phosphorylation	SPTKFINSFGNASSI CCCCHHHCCCCHHHC	29.70	22210691
1988	Phosphorylation	TSPQLINTTAKVPVP CCCCCEECCCCCCCC	22.57	22210691
1989	Phosphorylation	SPQLINTTAKVPVPP CCCCEECCCCCCCCC	21.72	22210691
2000	Phosphorylation	PVPPPVPTVSLTSVI CCCCCCCCCCHHEEC	23.98	-
2057	Phosphorylation	PEGAILNTINTPASK CCCCCCCCCCCCHHH	16.50	-
2082	Phosphorylation	IVVSASRSPASVFPA HHHHCCCCHHHCCHH	23.48	-
2085	Phosphorylation	SASRSPASVFPAFQS HCCCCHHHCCHHHHC	27.89	-
2092	Phosphorylation	SVFPAFQSSGLEKPD HCCHHHHCCCCCCCC	21.66	-
2093	Phosphorylation	VFPAFQSSGLEKPDR CCHHHHCCCCCCCCC	36.29	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2026_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2026_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2026_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K2026_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.