dbPTM

SHRM3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	SHRM3_HUMAN
UniProt AC	Q8TF72
Protein Name	Protein Shroom3
Gene Name	SHROOM3
Organism	Homo sapiens (Human).
Sequence Length	1996
Subcellular Localization	Cell junction, adherens junction. Cytoplasm, cytoskeleton. Colocalizes with F-actin in stress fibers and adherens junctions..
Protein Description	Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity)..
Protein Sequence	MMRTTEDFHKPSATLNSNTATKGRYIYLEAFLEGGAPWGFTLKGGLEHGEPLIISKVEEGGKADTLSSKLQAGDEVVHINEVTLSSSRKEAVSLVKGSYKTLRLVVRRDVCTDPGHADTGASNFVSPEHLTSGPQHRKAAWSGGVKLRLKHRRSEPAGRPHSWHTTKSGEKQPDASMMQISQGMIGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGAYPPCHLSPAKSTGSIDQLSHFHNKRDSAYSSFSTSSSILEYPHPGISGRERSGSMDNTSARGGLLEGMRQADIRYVKTVYDTRRGVSAEYEVNSSALLLQGREARASANGQGYDKWSNIPRGKGVPPPSWSQQCPSSLETATDNLPPKVGAPLPPARSDSYAAFRHRERPSSWSSLDQKRLCRPQANSLGSLKSPFIEEQLHTVLEKSPENSPPVKPKHNYTQKAQPGQPLLPTSIYPVPSLEPHFAQVPQPSVSSNGMLYPALAKESGYIAPQGACNKMATIDENGNQNGSGRPGFAFCQPLEHDLLSPVEKKPEATAKYVPSKVHFCSVPENEEDASLKRHLTPPQGNSPHSNERKSTHSNKPSSHPHSLKCPQAQAWQAGEDKRSSRLSEPWEGDFQEDHNANLWRRLEREGLGQSLSGNFGKTKSAFSSLQNIPESLRRHSSLELGRGTQEGYPGGRPTCAVNTKAEDPGRKAAPDLGSHLDRQVSYPRPEGRTGASASFNSTDPSPEEPPAPSHPHTSSLGRRGPGPGSASALQGFQYGKPHCSVLEKVSKFEQREQGSQRPSVGGSGFGHNYRPHRTVSTSSTSGNDFEETKAHIRFSESAEPLGNGEQHFKNGELKLEEASRQPCGQQLSGGASDSGRGPQRPDARLLRSQSTFQLSSEPEREPEWRDRPGSPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLELGAPVASRSWRPRPSSAHVGLRSPEASASASPHTPRERHSVTPAEGDLARPVPPAARRGARRRLTPEQKKRSYSEPEKMNEVGIVEEAEPAPLGPQRNGMRFPESSVADRRRLFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTSAAGCSLQEPGPLRERAQSAYLQPGPAALEGSGLASASSLSSLREPSLQPRREATLLPATVAETQQAPRDRSSSFAGGRRLGERRRGDLLSGANGGTRGTQRGDETPREPSSWGARAGKSMSAEDLLERSDVLAGPVHVRSRSSPATADKRQDVLLGQDSGFGLVKDPCYLAGPGSRSLSCSERGQEEMLPLFHHLTPRWGGSGCKAIGDSSVPSECPGTLDHQRQASRTPCPRPPLAGTQGLVTDTRAAPLTPIGTPLPSAIPSGYCSQDGQTGRQPLPPYTPAMMHRSNGHTLTQPPGPRGCEGDGPEHGVEEGTRKRVSLPQWPPPSRAKWAHAAREDSLPEESSAPDFANLKHYQKQQSLPSLCSTSDPDTPLGAPSTPGRISLRISESVLRDSPPPHEDYEDEVFVRDPHPKATSSPTFEPLPPPPPPPPSQETPVYSMDDFPPPPPHTVCEAQLDSEDPEGPRPSFNKLSKVTIARERHMPGAAHVVGSQTLASRLQTSIKGSEAESTPPSFMSVHAQLAGSLGGQPAPIQTQSLSHDPVSGTQGLEKKVSPDPQKSSEDIRTEALAKEIVHQDKSLADILDPDSRLKTTMDLMEGLFPRDVNLLKENSVKRKAIQRTVSSSGCEGKRNEDKEAVSMLVNCPAYYSVSAPKAELLNKIKEMPAEVNEEEEQADVNEKKAELIGSLTHKLETLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYRMFIGDLDKVVNLLLSLSGRLARVENVLSGLGEDASNEERSSLYEKRKILAGQHEDARELKENLDRRERVVLGILANYLSEEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVKCLLESLPSDFIPKAGALALPPNLTSEPIPAGGCTFSGIFPTLTSPL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TEDFHKPSATLNSNT CCCCCCCCCCCCCCC	38.39	29449344
14	Phosphorylation	DFHKPSATLNSNTAT CCCCCCCCCCCCCCC	30.70	29449344
17	Phosphorylation	KPSATLNSNTATKGR CCCCCCCCCCCCCCC	38.37	23532336
19	Phosphorylation	SATLNSNTATKGRYI CCCCCCCCCCCCCEE	35.21	29083192
19 (in isoform 2)	Phosphorylation	-	35.21	22210691
21	Phosphorylation	TLNSNTATKGRYIYL CCCCCCCCCCCEEEE	31.80	23532336
55	Phosphorylation	HGEPLIISKVEEGGK CCCCEEEEEEECCCC	24.53	28060719
112	Phosphorylation	VVRRDVCTDPGHADT EEECCCCCCCCCCCC	45.11	-
122	Phosphorylation	GHADTGASNFVSPEH CCCCCCCCCCCCHHH	31.95	-
131	Phosphorylation	FVSPEHLTSGPQHRK CCCHHHHCCCHHHHH	33.28	-
132	Phosphorylation	VSPEHLTSGPQHRKA CCHHHHCCCHHHHHH	55.63	-
162	Phosphorylation	EPAGRPHSWHTTKSG CCCCCCCCCCCCCCC	24.20	27794612
165	Phosphorylation	GRPHSWHTTKSGEKQ CCCCCCCCCCCCCCC	29.66	27794612
166	Phosphorylation	RPHSWHTTKSGEKQP CCCCCCCCCCCCCCC	15.43	27794612
170 (in isoform 2)	Phosphorylation	-	56.46	27174698
173 (in isoform 2)	Phosphorylation	-	50.64	27174698
174 (in isoform 2)	Phosphorylation	-	49.10	27174698
177 (in isoform 2)	Phosphorylation	-	2.16	27174698
178 (in isoform 2)	Phosphorylation	-	2.72	27174698
213	Phosphorylation	DHAYLRRSPDQCSSQ CHHHHCCCCCCCCCC	26.79	23663014
218	Phosphorylation	RRSPDQCSSQGSMES CCCCCCCCCCCCCCC	21.77	28857561
219	Phosphorylation	RSPDQCSSQGSMESL CCCCCCCCCCCCCCC	46.30	28857561
222	Phosphorylation	DQCSSQGSMESLEPS CCCCCCCCCCCCCCC	16.25	28857561
225	Phosphorylation	SSQGSMESLEPSGAY CCCCCCCCCCCCCCC	29.41	28857561
229	Phosphorylation	SMESLEPSGAYPPCH CCCCCCCCCCCCCCC	27.04	30177828
238	Phosphorylation	AYPPCHLSPAKSTGS CCCCCCCCCCCCCCC	10.11	21712546
242	Phosphorylation	CHLSPAKSTGSIDQL CCCCCCCCCCCHHHH	39.86	25159151
243	Phosphorylation	HLSPAKSTGSIDQLS CCCCCCCCCCHHHHH	33.95	25849741
245	Phosphorylation	SPAKSTGSIDQLSHF CCCCCCCCHHHHHHH	24.07	25849741
250	Phosphorylation	TGSIDQLSHFHNKRD CCCHHHHHHHCCCCC	20.62	20873877
258	Phosphorylation	HFHNKRDSAYSSFST HHCCCCCCCCCCCCC	32.89	30576142
260	Phosphorylation	HNKRDSAYSSFSTSS CCCCCCCCCCCCCCC	14.59	22817900
261	Phosphorylation	NKRDSAYSSFSTSSS CCCCCCCCCCCCCCC	25.32	27251275
262	Phosphorylation	KRDSAYSSFSTSSSI CCCCCCCCCCCCCCH	15.56	30576142
264	Phosphorylation	DSAYSSFSTSSSILE CCCCCCCCCCCCHHC	29.36	27251275
265	Phosphorylation	SAYSSFSTSSSILEY CCCCCCCCCCCHHCC	30.53	30576142
266	Phosphorylation	AYSSFSTSSSILEYP CCCCCCCCCCHHCCC	22.38	24719451
267	Phosphorylation	YSSFSTSSSILEYPH CCCCCCCCCHHCCCC	22.83	27251275
268	Phosphorylation	SSFSTSSSILEYPHP CCCCCCCCHHCCCCC	30.84	28985074
272	Phosphorylation	TSSSILEYPHPGISG CCCCHHCCCCCCCCC	11.91	28985074
283	Phosphorylation	GISGRERSGSMDNTS CCCCCCCCCCCCCCH	30.39	27282143
285	Phosphorylation	SGRERSGSMDNTSAR CCCCCCCCCCCCHHH	24.98	30576142
289	Phosphorylation	RSGSMDNTSARGGLL CCCCCCCCHHHCCHH	21.35	27794612
290	Phosphorylation	SGSMDNTSARGGLLE CCCCCCCHHHCCHHH	23.40	27794612
292	Methylation	SMDNTSARGGLLEGM CCCCCHHHCCHHHHH	39.21	115916961
318	Phosphorylation	YDTRRGVSAEYEVNS EECCCCCCEEEEECC	20.43	27251275
321	Phosphorylation	RRGVSAEYEVNSSAL CCCCCEEEEECCCHH	25.54	27259358
338	Phosphorylation	QGREARASANGQGYD CCHHHHHHCCCCCCC	19.40	29083192
344	Phosphorylation	ASANGQGYDKWSNIP HHCCCCCCCCCCCCC	13.38	29083192
348	Phosphorylation	GQGYDKWSNIPRGKG CCCCCCCCCCCCCCC	30.53	29083192
389	Phosphorylation	APLPPARSDSYAAFR CCCCCCCCCCCHHHC	32.77	-
391	Phosphorylation	LPPARSDSYAAFRHR CCCCCCCCCHHHCCC	20.23	28857561
392	Phosphorylation	PPARSDSYAAFRHRE CCCCCCCCHHHCCCC	13.62	27642862
402	Phosphorylation	FRHRERPSSWSSLDQ HCCCCCCCCCCCCCH	51.14	25159151
403	Phosphorylation	RHRERPSSWSSLDQK CCCCCCCCCCCCCHH	33.39	22617229
405	Phosphorylation	RERPSSWSSLDQKRL CCCCCCCCCCCHHHH	23.99	23090842
406	Phosphorylation	ERPSSWSSLDQKRLC CCCCCCCCCCHHHHC	29.70	22617229
413	S-palmitoylation	SLDQKRLCRPQANSL CCCHHHHCCCCCCCC	7.48	29575903
419	Phosphorylation	LCRPQANSLGSLKSP HCCCCCCCCCCCCCH	36.80	23401153
425	Phosphorylation	NSLGSLKSPFIEEQL CCCCCCCCHHHHHHH	30.27	24732914
434	Phosphorylation	FIEEQLHTVLEKSPE HHHHHHHHHHHHCCC	35.06	23898821
438	Phosphorylation	QLHTVLEKSPENSPP HHHHHHHHCCCCCCC	68.12	18669648
439	Phosphorylation	LHTVLEKSPENSPPV HHHHHHHCCCCCCCC	28.24	28355574
442	Phosphorylation	VLEKSPENSPPVKPK HHHHCCCCCCCCCCC	64.30	18669648
443	Phosphorylation	LEKSPENSPPVKPKH HHHCCCCCCCCCCCC	28.99	30278072
499	Phosphorylation	YPALAKESGYIAPQG HHHHHHHCCCCCCCC	35.87	21945579
501	Phosphorylation	ALAKESGYIAPQGAC HHHHHCCCCCCCCCC	11.82	21945579
540	Phosphorylation	PLEHDLLSPVEKKPE CCCCCCCCCCCCCCH	33.91	25159151
570	Phosphorylation	PENEEDASLKRHLTP CCCCCCCCHHHHCCC	46.90	23312004
575	Phosphorylation	DASLKRHLTPPQGNS CCCHHHHCCCCCCCC	9.99	18669648
576	Phosphorylation	ASLKRHLTPPQGNSP CCHHHHCCCCCCCCC	27.14	30266825
581	Phosphorylation	HLTPPQGNSPHSNER HCCCCCCCCCCCCCC	47.31	18669648
582	Phosphorylation	LTPPQGNSPHSNERK CCCCCCCCCCCCCCC	30.71	30266825
584	Phosphorylation	PPQGNSPHSNERKST CCCCCCCCCCCCCCC	42.97	18669648
585	Phosphorylation	PQGNSPHSNERKSTH CCCCCCCCCCCCCCC	43.71	30266825
597	Phosphorylation	STHSNKPSSHPHSLK CCCCCCCCCCCCCCC	42.77	24114839
602	Phosphorylation	KPSSHPHSLKCPQAQ CCCCCCCCCCCCHHH	33.69	24114839
619	Phosphorylation	QAGEDKRSSRLSEPW HCCCCHHHCCCCCCC	26.08	28348404
620	Phosphorylation	AGEDKRSSRLSEPWE CCCCHHHCCCCCCCC	41.07	25106551
623	Phosphorylation	DKRSSRLSEPWEGDF CHHHCCCCCCCCCCC	40.27	25106551
650	Phosphorylation	EREGLGQSLSGNFGK HHHCCCHHHCCCCCC	23.78	24173317
657	Methylation	SLSGNFGKTKSAFSS HHCCCCCCCHHHHHH	48.95	115981225
658	Phosphorylation	LSGNFGKTKSAFSSL HCCCCCCCHHHHHHH	30.52	23312004
659	Methylation	SGNFGKTKSAFSSLQ CCCCCCCHHHHHHHC	43.18	115981233
660	Phosphorylation	GNFGKTKSAFSSLQN CCCCCCHHHHHHHCC	39.51	30243723
663	Phosphorylation	GKTKSAFSSLQNIPE CCCHHHHHHHCCCCH	29.83	23927012
664	Phosphorylation	KTKSAFSSLQNIPES CCHHHHHHHCCCCHH	27.76	28355574
671	Phosphorylation	SLQNIPESLRRHSSL HHCCCCHHHHHCCCE	23.09	23927012
676	Phosphorylation	PESLRRHSSLELGRG CHHHHHCCCEECCCC	34.50	26055452
677	Phosphorylation	ESLRRHSSLELGRGT HHHHHCCCEECCCCC	21.53	25159151
684	Phosphorylation	SLELGRGTQEGYPGG CEECCCCCCCCCCCC	23.30	21406692
688	Phosphorylation	GRGTQEGYPGGRPTC CCCCCCCCCCCCCCE	9.65	21406692
694	Phosphorylation	GYPGGRPTCAVNTKA CCCCCCCCEECCCCC	16.25	21406692
699	Phosphorylation	RPTCAVNTKAEDPGR CCCEECCCCCCCCCC	25.65	21406692
721	Phosphorylation	SHLDRQVSYPRPEGR HHHCCCCCCCCCCCC	22.53	24719451
722	Phosphorylation	HLDRQVSYPRPEGRT HHCCCCCCCCCCCCC	12.38	26657352
729	Phosphorylation	YPRPEGRTGASASFN CCCCCCCCCCCCCCC	48.21	23312004
732	Phosphorylation	PEGRTGASASFNSTD CCCCCCCCCCCCCCC	26.28	23312004
734	Phosphorylation	GRTGASASFNSTDPS CCCCCCCCCCCCCCC	23.59	23312004
737	Phosphorylation	GASASFNSTDPSPEE CCCCCCCCCCCCCCC	31.98	29802988
738	Phosphorylation	ASASFNSTDPSPEEP CCCCCCCCCCCCCCC	53.70	28348404
741	Phosphorylation	SFNSTDPSPEEPPAP CCCCCCCCCCCCCCC	47.99	23312004
749	Phosphorylation	PEEPPAPSHPHTSSL CCCCCCCCCCCCCCC	52.32	25159151
753	Phosphorylation	PAPSHPHTSSLGRRG CCCCCCCCCCCCCCC	25.18	25159151
754	Phosphorylation	APSHPHTSSLGRRGP CCCCCCCCCCCCCCC	22.11	25159151
755	Phosphorylation	PSHPHTSSLGRRGPG CCCCCCCCCCCCCCC	35.68	25159151
774	Phosphorylation	SALQGFQYGKPHCSV HHHHCCCCCCCCCHH	25.51	-
799	Phosphorylation	EQGSQRPSVGGSGFG HCCCCCCCCCCCCCC	35.27	28555341
803	Phosphorylation	QRPSVGGSGFGHNYR CCCCCCCCCCCCCCC	25.64	28555341
814	Phosphorylation	HNYRPHRTVSTSSTS CCCCCCCEEECCCCC	18.77	22199227
815	Phosphorylation	NYRPHRTVSTSSTSG CCCCCCEEECCCCCC	6.23	18669648
816	Phosphorylation	YRPHRTVSTSSTSGN CCCCCEEECCCCCCC	23.20	27273156
817	Phosphorylation	RPHRTVSTSSTSGND CCCCEEECCCCCCCC	23.51	25159151
818	Phosphorylation	PHRTVSTSSTSGNDF CCCEEECCCCCCCCH	24.90	23911959
819	Phosphorylation	HRTVSTSSTSGNDFE CCEEECCCCCCCCHH	27.04	28355574
820	Phosphorylation	RTVSTSSTSGNDFEE CEEECCCCCCCCHHH	40.18	26657352
821	Phosphorylation	TVSTSSTSGNDFEET EEECCCCCCCCHHHH	37.23	22199227
835	Phosphorylation	TKAHIRFSESAEPLG HHHEEEECCCCCCCC	22.31	30576142
837	Phosphorylation	AHIRFSESAEPLGNG HEEEECCCCCCCCCC	36.41	25159151
888	Phosphorylation	PDARLLRSQSTFQLS CCHHHHHCCCCCCCC	28.58	27050516
890	Phosphorylation	ARLLRSQSTFQLSSE HHHHHCCCCCCCCCC	32.22	28355574
891	Phosphorylation	RLLRSQSTFQLSSEP HHHHCCCCCCCCCCC	14.04	29978859
895	Phosphorylation	SQSTFQLSSEPEREP CCCCCCCCCCCCCCC	23.13	23186163
896	Phosphorylation	QSTFQLSSEPEREPE CCCCCCCCCCCCCCC	66.80	23186163
909	Phosphorylation	PEWRDRPGSPESPLL CCCCCCCCCCCCCCC	57.64	18669648
910	Phosphorylation	EWRDRPGSPESPLLD CCCCCCCCCCCCCCC	28.33	22167270
912	Phosphorylation	RDRPGSPESPLLDAP CCCCCCCCCCCCCCC	67.68	18669648
913	Phosphorylation	DRPGSPESPLLDAPF CCCCCCCCCCCCCCC	25.00	23927012
921	Phosphorylation	PLLDAPFSRAYRNSI CCCCCCCCHHHHHHH	18.23	24732914
924	Phosphorylation	DAPFSRAYRNSIKDA CCCCCHHHHHHHHHH	14.82	25002506
927	Phosphorylation	FSRAYRNSIKDAQSR CCHHHHHHHHHHHHH	23.24	25394399
939	Phosphorylation	QSRVLGATSFRRRDL HHHHHCCCCHHHHHH	26.97	23312004
940	Phosphorylation	SRVLGATSFRRRDLE HHHHCCCCHHHHHHC	19.07	28355574
954	Phosphorylation	ELGAPVASRSWRPRP CCCCCCCCCCCCCCC	27.38	-
956	Phosphorylation	GAPVASRSWRPRPSS CCCCCCCCCCCCCCC	25.58	23312004
962	Phosphorylation	RSWRPRPSSAHVGLR CCCCCCCCCCCCCCC	41.24	25106551
963	Phosphorylation	SWRPRPSSAHVGLRS CCCCCCCCCCCCCCC	25.69	25106551
970	Phosphorylation	SAHVGLRSPEASASA CCCCCCCCHHHHCCC	31.94	26055452
974	Phosphorylation	GLRSPEASASASPHT CCCCHHHHCCCCCCC	22.54	26055452
976	Phosphorylation	RSPEASASASPHTPR CCHHHHCCCCCCCCC	27.12	26055452
978	Phosphorylation	PEASASASPHTPRER HHHHCCCCCCCCCCC	18.08	26055452
981	Phosphorylation	SASASPHTPRERHSV HCCCCCCCCCCCCCC	27.68	26055452
987	Phosphorylation	HTPRERHSVTPAEGD CCCCCCCCCCCCCCC	33.63	26657352
989	Phosphorylation	PRERHSVTPAEGDLA CCCCCCCCCCCCCCC	21.57	23312004
1012	Phosphorylation	RGARRRLTPEQKKRS HCHHHCCCHHHHHCC	23.98	28985074
1019	Phosphorylation	TPEQKKRSYSEPEKM CHHHHHCCCCCCHHH	41.72	26657352
1020	Phosphorylation	PEQKKRSYSEPEKMN HHHHHCCCCCCHHHH	22.53	26657352
1021	Phosphorylation	EQKKRSYSEPEKMNE HHHHCCCCCCHHHHC	48.17	23927012
1069	Phosphorylation	ERDGKACSTLSLSGP HCCCCCCCCCCCCCH	36.92	25159151
1070	Phosphorylation	RDGKACSTLSLSGPE CCCCCCCCCCCCCHH	21.91	25159151
1072	Phosphorylation	GKACSTLSLSGPELK CCCCCCCCCCCHHHH	22.15	23312004
1074	Phosphorylation	ACSTLSLSGPELKQF CCCCCCCCCHHHHHH	49.26	28348404
1089	Phosphorylation	QQSALADYIQRKTGK HHHHHHHHHHHHHCC	8.05	27642862
1099	Phosphorylation	RKTGKRPTSAAGCSL HHHCCCCCCCCCCCC	34.72	26657352
1100	Phosphorylation	KTGKRPTSAAGCSLQ HHCCCCCCCCCCCCC	20.85	25106551
1105	Phosphorylation	PTSAAGCSLQEPGPL CCCCCCCCCCCCCHH	31.97	28555341
1118	Phosphorylation	PLRERAQSAYLQPGP HHHHHHHHHHCCCCC	20.21	23090842
1120	Phosphorylation	RERAQSAYLQPGPAA HHHHHHHHCCCCCHH	15.89	23090842
1131	Phosphorylation	GPAALEGSGLASASS CCHHHCCCCCCCHHH	22.66	23090842
1135	Phosphorylation	LEGSGLASASSLSSL HCCCCCCCHHHHHHC	33.45	23090842
1137	Phosphorylation	GSGLASASSLSSLRE CCCCCCHHHHHHCCC	29.35	26657352
1138	Phosphorylation	SGLASASSLSSLREP CCCCCHHHHHHCCCC	31.80	25849741
1140	Phosphorylation	LASASSLSSLREPSL CCCHHHHHHCCCCCC	29.31	22167270
1141	Phosphorylation	ASASSLSSLREPSLQ CCHHHHHHCCCCCCC	36.42	22167270
1146	Phosphorylation	LSSLREPSLQPRREA HHHCCCCCCCCCHHH	34.58	28857561
1171	Phosphorylation	QQAPRDRSSSFAGGR CCCCCCCCCCCCCCC	34.32	24719451
1172	Phosphorylation	QAPRDRSSSFAGGRR CCCCCCCCCCCCCCC	30.30	28348404
1173	Phosphorylation	APRDRSSSFAGGRRL CCCCCCCCCCCCCCC	21.99	22817900
1199	Phosphorylation	ANGGTRGTQRGDETP CCCCCCCCCCCCCCC	16.29	-
1205	Phosphorylation	GTQRGDETPREPSSW CCCCCCCCCCCCCCH	32.17	28555341
1219	Phosphorylation	WGARAGKSMSAEDLL HHCCCCCCCCHHHHH	19.63	30266825
1220	Phosphorylation	GARAGKSMSAEDLLE HCCCCCCCCHHHHHH	5.12	18669648
1221	Phosphorylation	ARAGKSMSAEDLLER CCCCCCCCHHHHHHC	35.28	30266825
1229	Phosphorylation	AEDLLERSDVLAGPV HHHHHHCCCCCCCCE	23.77	30576142
1240	Phosphorylation	AGPVHVRSRSSPATA CCCEEEECCCCCCCC	35.11	26699800
1242	Phosphorylation	PVHVRSRSSPATADK CEEEECCCCCCCCCC	41.75	20363803
1243	Phosphorylation	VHVRSRSSPATADKR EEEECCCCCCCCCCC	19.90	28985074
1246	Phosphorylation	RSRSSPATADKRQDV ECCCCCCCCCCCCCE	38.48	23312004
1259	Phosphorylation	DVLLGQDSGFGLVKD CEECCCCCCCCCCCC	28.30	29802988
1269	Phosphorylation	GLVKDPCYLAGPGSR CCCCCCEEECCCCCC	12.65	21945579
1275	Phosphorylation	CYLAGPGSRSLSCSE EEECCCCCCCCCCHH	23.10	21945579
1277	Phosphorylation	LAGPGSRSLSCSERG ECCCCCCCCCCHHHC	26.74	28348404
1279	Phosphorylation	GPGSRSLSCSERGQE CCCCCCCCCHHHCCH	19.49	30576142
1281	Phosphorylation	GSRSLSCSERGQEEM CCCCCCCHHHCCHHH	27.27	30576142
1296	Phosphorylation	LPLFHHLTPRWGGSG HHHHCCCCCCCCCCC	13.37	25159151
1319	Phosphorylation	VPSECPGTLDHQRQA CCCCCCCCCCCCHHH	17.72	28555341
1339	Phosphorylation	PRPPLAGTQGLVTDT CCCCCCCCCCCCCCC	17.54	24043423
1344	Phosphorylation	AGTQGLVTDTRAAPL CCCCCCCCCCCCCCC	36.37	24043423
1346	Phosphorylation	TQGLVTDTRAAPLTP CCCCCCCCCCCCCCC	16.91	24043423
1352	Phosphorylation	DTRAAPLTPIGTPLP CCCCCCCCCCCCCCC	16.29	26657352
1356	Phosphorylation	APLTPIGTPLPSAIP CCCCCCCCCCCCCCC	23.52	21712546
1364	Phosphorylation	PLPSAIPSGYCSQDG CCCCCCCCCCCCCCC	35.96	28348404
1368	Phosphorylation	AIPSGYCSQDGQTGR CCCCCCCCCCCCCCC	23.87	29802988
1373	Phosphorylation	YCSQDGQTGRQPLPP CCCCCCCCCCCCCCC	39.60	28348404
1421	Phosphorylation	EGTRKRVSLPQWPPP CCCCCCCCCCCCCCC	38.06	27251275
1441	Phosphorylation	AHAAREDSLPEESSA HHHHCCCCCCCCCCC	40.86	28355574
1446	Phosphorylation	EDSLPEESSAPDFAN CCCCCCCCCCCCHHC	30.09	20068231
1447	Phosphorylation	DSLPEESSAPDFANL CCCCCCCCCCCHHCC	47.29	20068231
1462	Phosphorylation	KHYQKQQSLPSLCST HHHHHHHCCCCHHCC	39.49	26657352
1465	Phosphorylation	QKQQSLPSLCSTSDP HHHHCCCCHHCCCCC	47.50	30624053
1468	Phosphorylation	QSLPSLCSTSDPDTP HCCCCHHCCCCCCCC	35.92	30624053
1469	Phosphorylation	SLPSLCSTSDPDTPL CCCCHHCCCCCCCCC	35.83	30624053
1470	Phosphorylation	LPSLCSTSDPDTPLG CCCHHCCCCCCCCCC	30.74	30624053
1474	Phosphorylation	CSTSDPDTPLGAPST HCCCCCCCCCCCCCC	26.29	21406692
1480	Phosphorylation	DTPLGAPSTPGRISL CCCCCCCCCCCCEEE	46.85	21406692
1481	Phosphorylation	TPLGAPSTPGRISLR CCCCCCCCCCCEEEE	28.80	21815630
1486	Phosphorylation	PSTPGRISLRISESV CCCCCCEEEEEEHHH	15.38	27050516
1490	Phosphorylation	GRISLRISESVLRDS CCEEEEEEHHHHCCC	19.86	30266825
1492	Phosphorylation	ISLRISESVLRDSPP EEEEEEHHHHCCCCC	21.47	30266825
1497	Phosphorylation	SESVLRDSPPPHEDY EHHHHCCCCCCCCCC	32.64	30266825
1504	Phosphorylation	SPPPHEDYEDEVFVR CCCCCCCCCCCCEEC	23.46	30266825
1594	Phosphorylation	GAAHVVGSQTLASRL CCCEEECHHHHHHHH	14.37	23312004
1596	Phosphorylation	AHVVGSQTLASRLQT CEEECHHHHHHHHHH	26.45	23312004
1599	Phosphorylation	VGSQTLASRLQTSIK ECHHHHHHHHHHHHC	36.31	23312004
1656	Phosphorylation	QGLEKKVSPDPQKSS CCCCCCCCCCCCCCC	32.25	28102081
1662	Phosphorylation	VSPDPQKSSEDIRTE CCCCCCCCCHHHHHH	33.44	25849741
1663	Phosphorylation	SPDPQKSSEDIRTEA CCCCCCCCHHHHHHH	46.45	23898821
1681	Phosphorylation	EIVHQDKSLADILDP HHHHCCCCHHHHCCC	36.76	20860994
1690	Phosphorylation	ADILDPDSRLKTTMD HHHCCCCHHHHHHHH	44.92	20860994
1694	Phosphorylation	DPDSRLKTTMDLMEG CCCHHHHHHHHHHHC	31.76	22210691
1695	Phosphorylation	PDSRLKTTMDLMEGL CCHHHHHHHHHHHCC	13.70	22210691
1714	Phosphorylation	VNLLKENSVKRKAIQ HHHHCCCCHHHHHHH	30.06	24719451
1723	Phosphorylation	KRKAIQRTVSSSGCE HHHHHHHHHHHCCCC	14.36	29514088
1725	Phosphorylation	KAIQRTVSSSGCEGK HHHHHHHHHCCCCCC	20.41	27794612
1726	Phosphorylation	AIQRTVSSSGCEGKR HHHHHHHHCCCCCCC	26.81	29514088
1727	Phosphorylation	IQRTVSSSGCEGKRN HHHHHHHCCCCCCCC	39.70	29514088
1741	Phosphorylation	NEDKEAVSMLVNCPA CCCHHHHHHHHCCCC	17.28	21945579
1749	Phosphorylation	MLVNCPAYYSVSAPK HHHCCCCEECCCCCH	4.96	21945579
1750	Phosphorylation	LVNCPAYYSVSAPKA HHCCCCEECCCCCHH	12.52	21945579
1751	Phosphorylation	VNCPAYYSVSAPKAE HCCCCEECCCCCHHH	9.27	21945579
1753	Phosphorylation	CPAYYSVSAPKAELL CCCEECCCCCHHHHH	32.67	21945579
1803	Phosphorylation	TLQEAKGSLLTDIKL HHHHHHCCHHHHHHH	21.35	29396449
1806	Phosphorylation	EAKGSLLTDIKLNNA HHHCCHHHHHHHHHH	40.76	29396449
1834	Phosphorylation	KPNEFDKYRMFIGDL CCCCCHHHHHHHHCH	14.78	26074081
1850	Phosphorylation	KVVNLLLSLSGRLAR HHHHHHHHHHHHHHH	22.06	26074081
1852	Phosphorylation	VNLLLSLSGRLARVE HHHHHHHHHHHHHHH	20.63	26074081
1863	Phosphorylation	ARVENVLSGLGEDAS HHHHHHHHHCCCCCC	27.91	26074081
1929	Phosphorylation	QHFVKMKSTLLIEQR HHHHHHHHHHHEEEC	22.31	30266825
1930	Phosphorylation	HFVKMKSTLLIEQRK HHHHHHHHHHEEECC	21.77	30266825
1991	Phosphorylation	TFSGIFPTLTSPL-- CCCCCCCCCCCCC--	31.73	28348404
1993	Phosphorylation	SGIFPTLTSPL---- CCCCCCCCCCC----	30.67	24719451
1994	Phosphorylation	GIFPTLTSPL----- CCCCCCCCCC-----	27.58	29496963

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of SHRM3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of SHRM3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of SHRM3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of SHRM3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of SHRM3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439 AND SER-443, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-439; SER-443; THR-576;SER-582; SER-585; SER-910; SER-913 AND SER-1221, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910 AND SER-913, ANDMASS SPECTROMETRY.	18220336 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-910 AND SER-913, ANDMASS SPECTROMETRY.	17081983 [Abstract]