RNF10_HUMAN - dbPTM
RNF10_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RNF10_HUMAN
UniProt AC Q8N5U6
Protein Name RING finger protein 10
Gene Name RNF10
Organism Homo sapiens (Human).
Sequence Length 811
Subcellular Localization Cytoplasm . Nucleus .
Protein Description Transcriptional factor involved in the regulation of MAG (Myelin-associated glycoprotein) expression. Acts as a regulator of Schwann cell differentiation and myelination..
Protein Sequence MPLSSPNAAATASDMDKNSGSNSSSASSGSSKGQQPPRSASAGPAGESKPKSDGKNSSGSKRYNRKRELSYPKNESFNNQSRRSSSQKSKTFNKMPPQRGGGSSKLFSSSFNGGRRDEVAEAQRAEFSPAQFSGPKKINLNHLLNFTFEPRGQTGHFEGSGHGSWGKRNKWGHKPFNKELFLQANCQFVVSEDQDYTAHFADPDTLVNWDFVEQVRICSHEVPSCPICLYPPTAAKITRCGHIFCWACILHYLSLSEKTWSKCPICYSSVHKKDLKSVVATESHQYVVGDTITMQLMKREKGVLVALPKSKWMNVDHPIHLGDEQHSQYSKLLLASKEQVLHRVVLEEKVALEQQLAEEKHTPESCFIEAAIQELKTREEALSGLAGSRREVTGVVAALEQLVLMAPLAKESVFQPRKGVLEYLSAFDEETTEVCSLDTPSRPLALPLVEEEEAVSEPEPEGLPEACDDLELADDNLKEGTICTESSQQEPITKSGFTRLSSSPCYYFYQAEDGQHMFLHPVNVRCLVREYGSLERSPEKISATVVEIAGYSMSEDVRQRHRYLSHLPLTCEFSICELALQPPVVSKETLEMFSDDIEKRKRQRQKKAREERRRERRIEIEENKKQGKYPEVHIPLENLQQFPAFNSYTCSSDSALGPTSTEGHGALSISPLSRSPGSHADFLLTPLSPTASQGSPSFCVGSLEEDSPFPSFAQMLRVGKAKADVWPKTAPKKDENSLVPPAPVDSDGESDNSDRVPVPSFQNSFSQAIEAAFMKLDTPATSDPLSEEKGGKKRKKQKQKLLFSTSVVHTK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MPLSSPNAAAT
----CCCCCCCCCCC		37.5729255136
5Phosphorylation---MPLSSPNAAATA
---CCCCCCCCCCCH		29.8329255136
11PhosphorylationSSPNAAATASDMDKN
CCCCCCCCHHHCCCC		23.2029255136
13PhosphorylationPNAAATASDMDKNSG
CCCCCCHHHCCCCCC		29.1625627689
39PhosphorylationKGQQPPRSASAGPAG
CCCCCCCCCCCCCCC		32.1423403867
41PhosphorylationQQPPRSASAGPAGES
CCCCCCCCCCCCCCC		34.7025849741
48PhosphorylationSAGPAGESKPKSDGK
CCCCCCCCCCCCCCC		54.0323403867
49 (in isoform 2)Ubiquitination-52.76-
70PhosphorylationYNRKRELSYPKNESF
HCHHCCCCCCCCCCC		34.3424719451
71PhosphorylationNRKRELSYPKNESFN
CHHCCCCCCCCCCCC		30.7423312004
73UbiquitinationKRELSYPKNESFNNQ
HCCCCCCCCCCCCCC		66.18-
73 (in isoform 2)Ubiquitination-66.18-
76PhosphorylationLSYPKNESFNNQSRR
CCCCCCCCCCCCCCC		42.54-
84PhosphorylationFNNQSRRSSSQKSKT
CCCCCCCCCCCCCCC		32.9829038488
85PhosphorylationNNQSRRSSSQKSKTF
CCCCCCCCCCCCCCC		34.6726074081
86PhosphorylationNQSRRSSSQKSKTFN
CCCCCCCCCCCCCCC		42.7626074081
89PhosphorylationRRSSSQKSKTFNKMP
CCCCCCCCCCCCCCC		29.3229038488
103PhosphorylationPPQRGGGSSKLFSSS
CCCCCCCCCCCCCCC		27.81-
105 (in isoform 2)Ubiquitination-56.0721890473
105 (in isoform 1)Ubiquitination-56.0721890473
105UbiquitinationQRGGGSSKLFSSSFN
CCCCCCCCCCCCCCC		56.072189047
108PhosphorylationGGSSKLFSSSFNGGR
CCCCCCCCCCCCCCC		35.1923403867
109PhosphorylationGSSKLFSSSFNGGRR
CCCCCCCCCCCCCCH		31.4523403867
110PhosphorylationSSKLFSSSFNGGRRD
CCCCCCCCCCCCCHH		22.8723401153
128PhosphorylationEAQRAEFSPAQFSGP
HHHHHCCCCCHHCCC		15.7225159151
133PhosphorylationEFSPAQFSGPKKINL
CCCCCHHCCCCEECC		41.9525159151
136 (in isoform 2)Ubiquitination-70.57-
136UbiquitinationPAQFSGPKKINLNHL
CCHHCCCCEECCCCE		70.57-
137UbiquitinationAQFSGPKKINLNHLL
CHHCCCCEECCCCEE		39.70-
137 (in isoform 2)Ubiquitination-39.70-
147PhosphorylationLNHLLNFTFEPRGQT
CCCEEEEEEECCCCC		26.4728842319
154PhosphorylationTFEPRGQTGHFEGSG
EEECCCCCCCCCCCC		35.1323927012
160PhosphorylationQTGHFEGSGHGSWGK
CCCCCCCCCCCCCCC		22.0329449344
164PhosphorylationFEGSGHGSWGKRNKW
CCCCCCCCCCCCCCC		27.2928450419
277PhosphorylationVHKKDLKSVVATESH
CCHHHHHHHEECCCC		29.17-
286PhosphorylationVATESHQYVVGDTIT
EECCCCEEEECCEEH		7.5322210691
291PhosphorylationHQYVVGDTITMQLMK
CEEEECCEEHHHHHH		16.6522210691
293PhosphorylationYVVGDTITMQLMKRE
EEECCEEHHHHHHCC		10.8522210691
301AcetylationMQLMKREKGVLVALP
HHHHHCCCCEEEEEE		59.357681347
309AcetylationGVLVALPKSKWMNVD
CEEEEEECCCCCCCC		66.577681359
311UbiquitinationLVALPKSKWMNVDHP
EEEEECCCCCCCCCC		57.50-
311 (in isoform 2)Ubiquitination-57.50-
331UbiquitinationEQHSQYSKLLLASKE
HHHHHHHHHHHHCHH		37.91-
337UbiquitinationSKLLLASKEQVLHRV
HHHHHHCHHHHHHHH		46.70-
337 (in isoform 2)Ubiquitination-46.70-
349 (in isoform 2)Ubiquitination-24.35-
349UbiquitinationHRVVLEEKVALEQQL
HHHHHHHHHHHHHHH		24.35-
360UbiquitinationEQQLAEEKHTPESCF
HHHHHHCCCCHHHHH		44.26-
376 (in isoform 2)Ubiquitination-44.79-
376UbiquitinationEAAIQELKTREEALS
HHHHHHHHHHHHHHH		44.79-
393PhosphorylationAGSRREVTGVVAALE
CCCHHHHHHHHHHHH		21.36-
456PhosphorylationVEEEEAVSEPEPEGL
ECHHHHCCCCCCCCC		55.2520873877
481PhosphorylationDDNLKEGTICTESSQ
CCCCCCCCCCCCCCC		17.6125072903
484PhosphorylationLKEGTICTESSQQEP
CCCCCCCCCCCCCCC		34.7425072903
486PhosphorylationEGTICTESSQQEPIT
CCCCCCCCCCCCCCC		18.4625159151
487PhosphorylationGTICTESSQQEPITK
CCCCCCCCCCCCCCC		29.6525159151
494UbiquitinationSQQEPITKSGFTRLS
CCCCCCCCCCCEECC		49.67-
499 (in isoform 2)Ubiquitination-30.25-
502PhosphorylationSGFTRLSSSPCYYFY
CCCEECCCCCEEEEE		42.78-
503PhosphorylationGFTRLSSSPCYYFYQ
CCEECCCCCEEEEEE		18.66-
533PhosphorylationCLVREYGSLERSPEK
HHHHCCCCCCCCHHH		26.5926091039
544PhosphorylationSPEKISATVVEIAGY
CHHHEEEEEEEHHCC		20.4929507054
551PhosphorylationTVVEIAGYSMSEDVR
EEEEHHCCCCCHHHH		7.6829507054
552PhosphorylationVVEIAGYSMSEDVRQ
EEEHHCCCCCHHHHH		18.2122210691
554PhosphorylationEIAGYSMSEDVRQRH
EHHCCCCCHHHHHHH		25.3822210691
594PhosphorylationKETLEMFSDDIEKRK
HHHHHHHHHHHHHHH		32.8222199227
624UbiquitinationRIEIEENKKQGKYPE
HHHHHHHHHCCCCCC		50.15-
647PhosphorylationQQFPAFNSYTCSSDS
HCCCCCCCEEECCCC		18.5027251275
648PhosphorylationQFPAFNSYTCSSDSA
CCCCCCCEEECCCCC		16.9327251275
649PhosphorylationFPAFNSYTCSSDSAL
CCCCCCEEECCCCCC		13.0127251275
651PhosphorylationAFNSYTCSSDSALGP
CCCCEEECCCCCCCC		29.4027251275
652PhosphorylationFNSYTCSSDSALGPT
CCCEEECCCCCCCCC		37.4227251275
654PhosphorylationSYTCSSDSALGPTST
CEEECCCCCCCCCCC		27.6027251275
659PhosphorylationSDSALGPTSTEGHGA
CCCCCCCCCCCCCCC		46.6228348404
660PhosphorylationDSALGPTSTEGHGAL
CCCCCCCCCCCCCCE		27.8228348404
661PhosphorylationSALGPTSTEGHGALS
CCCCCCCCCCCCCEE		48.7628348404
668PhosphorylationTEGHGALSISPLSRS
CCCCCCEEECCCCCC		22.0828348404
670PhosphorylationGHGALSISPLSRSPG
CCCCEEECCCCCCCC		19.2027251275
675PhosphorylationSISPLSRSPGSHADF
EECCCCCCCCCCCCE		30.1828348404
688PhosphorylationDFLLTPLSPTASQGS
CEEEEECCCCCCCCC		22.7728348404
690PhosphorylationLLTPLSPTASQGSPS
EEEECCCCCCCCCCC		35.2528348404
692PhosphorylationTPLSPTASQGSPSFC
EECCCCCCCCCCCEE		37.2428348404
695PhosphorylationSPTASQGSPSFCVGS
CCCCCCCCCCEECEE		15.1028348404
697PhosphorylationTASQGSPSFCVGSLE
CCCCCCCCEECEECC		32.7328348404
702PhosphorylationSPSFCVGSLEEDSPF
CCCEECEECCCCCCC		16.5328464451
722AcetylationMLRVGKAKADVWPKT
HHHHCCCCCCCCCCC		48.917407629
728UbiquitinationAKADVWPKTAPKKDE
CCCCCCCCCCCCCCC		41.42-
737PhosphorylationAPKKDENSLVPPAPV
CCCCCCCCCCCCCCC		28.7922468782
746PhosphorylationVPPAPVDSDGESDNS
CCCCCCCCCCCCCCC		47.9927732954
750PhosphorylationPVDSDGESDNSDRVP
CCCCCCCCCCCCCCC		47.8527732954
753PhosphorylationSDGESDNSDRVPVPS
CCCCCCCCCCCCCHH		31.6127732954
786PhosphorylationPATSDPLSEEKGGKK
CCCCCCCCCCCCCCC		49.4422199227
804PhosphorylationQKQKLLFSTSVVHTK
HHHHHHEEECCCCCC		21.5329978859
805PhosphorylationKQKLLFSTSVVHTK-
HHHHHEEECCCCCC-		20.4329978859
806PhosphorylationQKLLFSTSVVHTK--
HHHHEEECCCCCC--		22.4229978859
810PhosphorylationFSTSVVHTK------
EEECCCCCC------		27.1729978859
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RNF10_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RNF10_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RNF10_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
CC90B_HUMANCCDC90Bphysical
16169070
LRIF1_HUMANLRIF1physical
16169070
UT14A_HUMANUTP14Aphysical
16169070
EF1A1_HUMANEEF1A1physical
16169070
SETB1_HUMANSETDB1physical
16169070
TLE1_HUMANTLE1physical
16169070
MEOX2_HUMANMEOX2physical
16335786
KDM1A_HUMANKDM1Aphysical
23455924
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RNF10_HUMAN

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Related Literatures of Post-Translational Modification

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