| UniProt ID | MEOX2_HUMAN | |
|---|---|---|
| UniProt AC | P50222 | |
| Protein Name | Homeobox protein MOX-2 | |
| Gene Name | MEOX2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 304 | |
| Subcellular Localization | Nucleus . Nucleus speckle . | |
| Protein Description | Mesodermal transcription factor that plays a key role in somitogenesis and is required for sclerotome development (By similarity). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. [PubMed: 22206000 May have a regulatory role when quiescent vascular smooth muscle cells reenter the cell cycle.] | |
| Protein Sequence | MEHPLFGCLRSPHATAQGLHPFSQSSLALHGRSDHMSYPELSTSSSSCIIAGYPNEEGMFASQHHRGHHHHHHHHHHHHHQQQQHQALQTNWHLPQMSSPPSAARHSLCLQPDSGGPPELGSSPPVLCSNSSSLGSSTPTGAACAPGDYGRQALSPAEAEKRSGGKRKSDSSDSQEGNYKSEVNSKPRKERTAFTKEQIRELEAEFAHHNYLTRLRRYEIAVNLDLTERQVKVWFQNRRMKWKRVKGGQQGAAAREKELVNVKKGTLLPSELSGIGAATLQQTGDSIANEDSHDSDHSSEHAHL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 129 | Phosphorylation | SSPPVLCSNSSSLGS CCCCEEECCCCCCCC | 35.27 | 27251275 | |
| 131 | Phosphorylation | PPVLCSNSSSLGSST CCEEECCCCCCCCCC | 12.66 | 27251275 | |
| 132 | Phosphorylation | PVLCSNSSSLGSSTP CEEECCCCCCCCCCC | 33.56 | 27251275 | |
| 133 | Phosphorylation | VLCSNSSSLGSSTPT EEECCCCCCCCCCCC | 36.25 | 27251275 | |
| 136 | Phosphorylation | SNSSSLGSSTPTGAA CCCCCCCCCCCCCCC | 36.01 | 27251275 | |
| 137 | Phosphorylation | NSSSLGSSTPTGAAC CCCCCCCCCCCCCCC | 36.29 | 27251275 | |
| 138 | Phosphorylation | SSSLGSSTPTGAACA CCCCCCCCCCCCCCC | 26.94 | 27251275 | |
| 155 | Phosphorylation | DYGRQALSPAEAEKR CHHHCCCCHHHHHHH | 25.69 | 23403867 | |
| 169 | Phosphorylation | RSGGKRKSDSSDSQE HHCCCCCCCCCCCCC | 46.92 | 25278378 | |
| 171 | Phosphorylation | GGKRKSDSSDSQEGN CCCCCCCCCCCCCCC | 43.04 | 25278378 | |
| 172 | Phosphorylation | GKRKSDSSDSQEGNY CCCCCCCCCCCCCCC | 46.39 | 25278378 | |
| 174 | Phosphorylation | RKSDSSDSQEGNYKS CCCCCCCCCCCCCHH | 31.89 | 25278378 | |
| 179 | Phosphorylation | SDSQEGNYKSEVNSK CCCCCCCCHHHHCCC | 27.09 | 25278378 | |
| 185 | Phosphorylation | NYKSEVNSKPRKERT CCHHHHCCCCCHHHC | 49.57 | - | |
| 292 | Phosphorylation | DSIANEDSHDSDHSS CCCCCCCCCCCCCCC | 24.02 | 28842319 | |
| 295 | Phosphorylation | ANEDSHDSDHSSEHA CCCCCCCCCCCCCCC | 31.62 | 22617229 | |
| 298 | Phosphorylation | DSHDSDHSSEHAHL- CCCCCCCCCCCCCC- | 42.27 | 22617229 | |
| 299 | Phosphorylation | SHDSDHSSEHAHL-- CCCCCCCCCCCCC-- | 29.95 | 28842319 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MEOX2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MEOX2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MEOX2_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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