PAX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PAX1_HUMAN
• UniProt AC: P15863
• Protein Name: Paired box protein Pax-1
• Gene Name: PAX1
• Organism: Homo sapiens (Human).
• Sequence Length: 534
• Subcellular Localization: Nucleus.
• Protein Description: This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity)..
• Protein Sequence: MKFTLGLGSRAWRVSWEGAAAAAAGPGAGGSALRCRAQRVSSPRLGRRGSRLSGALPLCLSRGGGGAQALPDCAGPSPGHPGHPGARQLAGPLAMEQTYGEVNQLGGVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPRVTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEASKQPPSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTFMEQTGALAGSEGTAYSPKMEDWAGVNRTAFPATPAVNGLEKPALEADIKYTQSASTLSAVGGFLPACAYPASNQHGVYSAPGGGYLAPGPPWPPAQGPPLAPPGAGVAVHGGELAAAMTFKHPSREGSLPAPAARPRTPSVAYTDCPSRPRPPRGSSPRTRARRERQADPGAQVCAAAPAIGTGRIGGLAEEEASAGPRGARPASPQAQPCLWPDPPHFLYWSGFLGFSELGF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
31	Phosphorylation	AGPGAGGSALRCRAQ CCCCCCHHHHHHHHH	24.18	-
48	Dimethylation	SSPRLGRRGSRLSGA CCCCCCCCCCCHHCH	45.71	-
48	Methylation	SSPRLGRRGSRLSGA CCCCCCCCCCCHHCH	45.71	54561603
51	Dimethylation	RLGRRGSRLSGALPL CCCCCCCCHHCHHHH	35.38	-
51	Methylation	RLGRRGSRLSGALPL CCCCCCCCHHCHHHH	35.38	54561609
154	Phosphorylation	VSKILARYNETGSIL HHHHHHHHCCCCCCC	16.25	22210691
157	Phosphorylation	ILARYNETGSILPGA HHHHHCCCCCCCCCC	32.37	22210691
159	Phosphorylation	ARYNETGSILPGAIG HHHCCCCCCCCCCCC	28.50	22210691
208	Ubiquitination	LADGVCDKYNVPSVS HHCCCCCCCCCCCHH	33.33	-
237	Phosphorylation	QPGPYEASKQPPSQP CCCCCCCCCCCCCCC	21.63	30576142
245	Phosphorylation	KQPPSQPTLPYNHIY CCCCCCCCCCCCCCC	32.50	30576142
261	Phosphorylation	YPYPSPVSPTGAKMG CCCCCCCCCCCCCCC	21.81	28348404
281	Phosphorylation	PGTAGHVSIPRSWPS CCCCCCCCCCCCCCC	22.62	24719451
300	Phosphorylation	SNILGIRTFMEQTGA HHHHCHHHHHHHHCC	25.97	21406692
305	Phosphorylation	IRTFMEQTGALAGSE HHHHHHHHCCCCCCC	15.89	21406692
311	Phosphorylation	QTGALAGSEGTAYSP HHCCCCCCCCCCCCC	27.52	21406692
314	Phosphorylation	ALAGSEGTAYSPKME CCCCCCCCCCCCCHH	20.54	21406692
316	Phosphorylation	AGSEGTAYSPKMEDW CCCCCCCCCCCHHHC	25.91	21406692
317	Phosphorylation	GSEGTAYSPKMEDWA CCCCCCCCCCHHHCC	18.64	21406692
328	Methylation	EDWAGVNRTAFPATP HHCCCCCCCCCCCCC	25.65	115384341
439	Phosphorylation	APAARPRTPSVAYTD CCCCCCCCCCCEECC	23.69	30576142
441	Phosphorylation	AARPRTPSVAYTDCP CCCCCCCCCEECCCC	20.83	30576142
444	Phosphorylation	PRTPSVAYTDCPSRP CCCCCCEECCCCCCC	10.85	30576142
458	Phosphorylation	PRPPRGSSPRTRARR CCCCCCCCHHHHHHH	22.64	25332170
484	Phosphorylation	AAAPAIGTGRIGGLA HHCCCCCCCCCCCHH	19.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PAX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PAX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PAX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MEOX1_HUMAN	MEOX1	physical	11423130
MEOX2_HUMAN	MEOX2	physical	11423130

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.