MEOX1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MEOX1_HUMAN
• UniProt AC: P50221
• Protein Name: Homeobox protein MOX-1
• Gene Name: MEOX1
• Organism: Homo sapiens (Human).
• Sequence Length: 254
• Subcellular Localization: Nucleus . Cytoplasm . Localizes predominantly in the nucleus.
• Protein Description: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints. [PubMed: 23290072]
• Protein Sequence: MDPAASSCMRSLQPPAPVWGCLRNPHSEGNGASGLPHYPPTPFSFHQKPDFLATATAAYPDFSASCLAATPHSLPQEEHIFTEQHPAFPQSPNWHFPVSDARRRPNSGPAGGSKEMGTSSLGLVDTTGGPGDDYGVLGSTANETEKKSSRRRKESSDNQENRGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPISPNGQDPEDGDSTASPSSE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDPAASSCMRSLQ --CCHHHHHHHHHCC	26.61	22210691
29	Phosphorylation	LRNPHSEGNGASGLP CCCCCCCCCCCCCCC	40.67	24719451
33	Phosphorylation	HSEGNGASGLPHYPP CCCCCCCCCCCCCCC	42.11	24719451
107	Phosphorylation	DARRRPNSGPAGGSK HHCCCCCCCCCCCCC	49.16	27461979
121	Phosphorylation	KEMGTSSLGLVDTTG CCCCCCCCCEECCCC	6.52	24719451
134	Phosphorylation	TGGPGDDYGVLGSTA CCCCCCCCCCCCCCC	17.55	27642862
137	Phosphorylation	PGDDYGVLGSTANET CCCCCCCCCCCCCHH	3.78	24719451
144	Phosphorylation	LGSTANETEKKSSRR CCCCCCHHHHHHHHH	53.57	24719451
148	Phosphorylation	ANETEKKSSRRRKES CCHHHHHHHHHHHHC	39.90	24719451
155 (in isoform 2)	Phosphorylation	-	46.13	27174698
156 (in isoform 2)	Phosphorylation	-	41.49	27174698
159 (in isoform 2)	Phosphorylation	-	55.09	27174698
236	Phosphorylation	VKGGQPISPNGQDPE ECCCCCCCCCCCCCC	20.99	22210691
247	Phosphorylation	QDPEDGDSTASPSSE CCCCCCCCCCCCCCC	31.25	22210691
248	Phosphorylation	DPEDGDSTASPSSE- CCCCCCCCCCCCCC-	35.57	22210691
252	Phosphorylation	GDSTASPSSE----- CCCCCCCCCC-----	44.60	27251275
253	Phosphorylation	DSTASPSSE------ CCCCCCCCC------	51.19	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MEOX1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MEOX1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MEOX1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PAX1_HUMAN	PAX1	physical	11423130
PAX3_HUMAN	PAX3	physical	11423130
A4_HUMAN	APP	physical	21832049
TRI18_HUMAN	MID1	physical	25416956
MK09_HUMAN	MAPK9	physical	25416956
RANB3_HUMAN	RANBP3	physical	25416956
CIAO1_HUMAN	CIAO1	physical	25416956
MO4L1_HUMAN	MORF4L1	physical	25416956
DP13A_HUMAN	APPL1	physical	25416956
SYT17_HUMAN	SYT17	physical	25416956
QRIC1_HUMAN	QRICH1	physical	25416956
UB2R2_HUMAN	UBE2R2	physical	25416956
NAGK_HUMAN	NAGK	physical	25416956
CIB3_HUMAN	CIB3	physical	25416956
UBX2B_HUMAN	UBXN2B	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
TEANC_HUMAN	TCEANC	physical	25416956
TXLNA_HUMAN	TXLNA	physical	25416956
NEIL2_HUMAN	NEIL2	physical	25416956
NIF3L_HUMAN	NIF3L1	physical	26186194
MEOX2_HUMAN	MEOX2	physical	26186194
CHM1A_HUMAN	CHMP1A	physical	26186194
PRPK_HUMAN	TP53RK	physical	26186194
MEOX2_HUMAN	MEOX2	physical	28514442
CHM1A_HUMAN	CHMP1A	physical	28514442
NIF3L_HUMAN	NIF3L1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.