dbPTM

PAX3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PAX3_HUMAN
UniProt AC	P23760
Protein Name	Paired box protein Pax-3
Gene Name	PAX3
Organism	Homo sapiens (Human).
Sequence Length	479
Subcellular Localization	Nucleus .
Protein Description	Transcription factor that may regulate cell proliferation, migration and apoptosis. Involved in neural development and myogenesis. Transcriptional activator of MITF, acting synergistically with SOX10. [PubMed: 21965087]
Protein Sequence	MTTLAGAVPRMMRPGPGQNYPRSGFPLEVSTPLGQGRVNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIGGSKPKQVTTPDVEKKIEEYKRENPGMFSWEIRDKLLKDAVCDRNTVPSVSSISRILRSKFGKGEEEEADLERKEAEESEKKAKHSIDGILSERASAPQSDEGSDIDSEPDLPLKRKQRRSRTTFTAEQLEELERAFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQAGANQLMAFNHLIPGGFPPTAMPTLPTYQLSETSYQPTSIPQAVSDPSSTVHRPQPLPPSTVHQSTIPSNPDSSSAYCLPSTRHGFSSYTDSFVPPSGPSNPMNPTIGNGLSPQVMGLLTNHGGVPHQPQTDYALSPLTGGLEPTTTVSASCSQRLDHMKSLDSLPTSQSYCPPTYSTTGYSMDPVTGYQYGQYGQSKPWTF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTTLAGAVP ------CCCHHCCCC	30.43	29262532
3	Phosphorylation	-----MTTLAGAVPR -----CCCHHCCCCC	17.20	29262532
107	Acetylation	AIGGSKPKQVTTPDV CCCCCCCCCCCCCCH	62.22	7975495
116	Acetylation	VTTPDVEKKIEEYKR CCCCCHHHHHHHHHH	59.92	7975507
121	Phosphorylation	VEKKIEEYKRENPGM HHHHHHHHHHHCCCC	11.53	-
155	Phosphorylation	VPSVSSISRILRSKF CCCHHHHHHHHHHHH	18.40	25247763
182	Acetylation	KEAEESEKKAKHSID HHHHHHHHHHHHHHH	68.27	19828281
183	Acetylation	EAEESEKKAKHSIDG HHHHHHHHHHHHHHH	59.63	19828291
187 (in isoform 3)	Phosphorylation	-	22.97	24719451
197	Phosphorylation	GILSERASAPQSDEG HHHHCCCCCCCCCCC	46.86	22617229
201	Phosphorylation	ERASAPQSDEGSDID CCCCCCCCCCCCCCC	36.25	27251789
204 (in isoform 3)	Phosphorylation	-	35.29	24719451
205	Phosphorylation	APQSDEGSDIDSEPD CCCCCCCCCCCCCCC	29.37	27251789
209	Phosphorylation	DEGSDIDSEPDLPLK CCCCCCCCCCCCCCC	51.90	21440083
436	Ubiquitination	CSQRLDHMKSLDSLP HHHHHHHHHCCCCCC	2.92	17662948
436	Acetylation	CSQRLDHMKSLDSLP HHHHHHHHHCCCCCC	2.92	17662948
437	Ubiquitination	SQRLDHMKSLDSLPT HHHHHHHHCCCCCCC	44.43	17662948
437	Acetylation	SQRLDHMKSLDSLPT HHHHHHHHCCCCCCC	44.43	21169561
475	Ubiquitination	YGQYGQSKPWTF--- CCCCCCCCCCCC---	36.37	-
475	Acetylation	YGQYGQSKPWTF--- CCCCCCCCCCCC---	36.37	21169561
496 (in isoform 8)	Phosphorylation	-		-
497 (in isoform 8)	Phosphorylation	-		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
205	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	FZR1	Q9UM11	PMID:26329581

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PAX3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PAX3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IPO13_HUMAN	IPO13	physical	15143176
SOX10_HUMAN	SOX10	physical	12668617
DAXX_HUMAN	DAXX	physical	10393185
MSX1_HUMAN	MSX1	physical	10529415
MEOX1_HUMAN	MEOX1	physical	11423130
MEOX2_HUMAN	MEOX2	physical	11423130
SOX10_HUMAN	SOX10	genetic	10942418
HDA10_HUMAN	HDAC10	physical	20032463
TIF1B_HUMAN	TRIM28	physical	20032463
TIF1B_HUMAN	TRIM28	physical	16945326
TAF1_HUMAN	TAF1	physical	21145483
FZR1_HUMAN	FZR1	physical	26329581

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
193500	Waardenburg syndrome 1 (WS1)
148820	Waardenburg syndrome 3 (WS3)
122880	Craniofacial-deafness-hand syndrome (CDHS)
268220	Rhabdomyosarcoma 2 (RMS2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PAX3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Identification of serines 201 and 209 as sites of Pax3phosphorylation and the altered phosphorylation status of Pax3-FOXO1during early myogenic differentiation."; Dietz K.N., Miller P.J., Iyengar A.S., Loupe J.M., Hollenbach A.D.; Int. J. Biochem. Cell Biol. 43:936-945(2011). Cited for: PHOSPHORYLATION AT SER-201; SER-205 AND SER-209.	21440083 [Abstract]