| UniProt ID | HDA10_HUMAN | |
|---|---|---|
| UniProt AC | Q969S8 | |
| Protein Name | Histone deacetylase 10 | |
| Gene Name | HDAC10 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 669 | |
| Subcellular Localization | Cytoplasm. Nucleus. Excluded from the nucleoli. | |
| Protein Description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.. | |
| Protein Sequence | MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 65 | Phosphorylation | EELGLVHSPEYVSLV HHHCCCCCHHHHHHH | 16.37 | 24719451 | |
| 68 | Phosphorylation | GLVHSPEYVSLVRET CCCCCHHHHHHHHHE | 9.95 | 24719451 | |
| 70 | Phosphorylation | VHSPEYVSLVRETQV CCCHHHHHHHHHEEC | 21.90 | 28796482 | |
| 80 | Ubiquitination | RETQVLGKEELQALS HHEECCCHHHHHHHH | 43.80 | - | |
| 160 | Ubiquitination | AAAHAKQKHGLHRIL HHHHHHHHHCCCEEE | 38.64 | - | |
| 355 | Ubiquitination | AAQAPHWKSLQQQDV HHCCCCHHHHHHCCC | 37.95 | - | |
| 363 | Phosphorylation | SLQQQDVTAVPMSPS HHHHCCCCEEECCCC | 30.17 | 27080861 | |
| 368 | Phosphorylation | DVTAVPMSPSSHSPE CCCEEECCCCCCCCC | 18.63 | 23401153 | |
| 370 | Phosphorylation | TAVPMSPSSHSPEGR CEEECCCCCCCCCCC | 33.12 | 28450419 | |
| 371 | Phosphorylation | AVPMSPSSHSPEGRP EEECCCCCCCCCCCC | 31.22 | 28450419 | |
| 373 | Phosphorylation | PMSPSSHSPEGRPPP ECCCCCCCCCCCCCC | 26.96 | 28450419 | |
| 393 | Phosphorylation | PVCKAAASAPSSLLD HHHHHCCCCCHHHCC | 35.67 | 11861901 | |
| 540 | Phosphorylation | GKEAAALSMFHVSTP CHHHHHHHHCCCCCC | 18.06 | - | |
| 639 | Ubiquitination | SLGPSSVASPEDVQA CCCCCCCCCHHHHHH | 22.70 | 22505724 | |
| 659 | Ubiquitination | GQLEPQWKMLQCHPH CCCCHHHHHCCCCCC | 25.20 | 22505724 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HDA10_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HDA10_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HDA10_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HDAC3_HUMAN | HDAC3 | physical | 11861901 | |
| HDAC2_HUMAN | HDAC2 | physical | 11739383 | |
| NCOR2_HUMAN | NCOR2 | physical | 11739383 | |
| HSP7C_HUMAN | HSPA8 | physical | 20032463 | |
| PAX3_HUMAN | PAX3 | physical | 20032463 | |
| TIF1B_HUMAN | TRIM28 | physical | 20032463 | |
| JDP2_HUMAN | JDP2 | physical | 22989952 | |
| ATF3_HUMAN | ATF3 | physical | 22989952 | |
| ZBT7B_HUMAN | ZBTB7B | physical | 22730529 | |
| COPB_HUMAN | COPB1 | physical | 23752268 | |
| DNJA1_HUMAN | DNAJA1 | physical | 23752268 | |
| P4HA1_HUMAN | P4HA1 | physical | 23752268 | |
| PDIA3_HUMAN | PDIA3 | physical | 23752268 | |
| RAC2_HUMAN | RAC2 | physical | 23752268 | |
| FDFT_HUMAN | FDFT1 | physical | 23752268 | |
| TXND5_HUMAN | TXNDC5 | physical | 23752268 | |
| PCBP3_HUMAN | PCBP3 | physical | 28514442 | |
| LTMD1_HUMAN | LETMD1 | physical | 28514442 | |
| NDUB5_HUMAN | NDUFB5 | physical | 28514442 | |
| QCR6_HUMAN | UQCRH | physical | 28514442 | |
| ZFPL1_HUMAN | ZFPL1 | physical | 28514442 | |
| GNPAT_HUMAN | GNPAT | physical | 28514442 | |
| EPHA4_HUMAN | EPHA4 | physical | 28514442 | |
| SPG7_HUMAN | SPG7 | physical | 28514442 | |
| P4K2B_HUMAN | PI4K2B | physical | 28514442 | |
| ABHEA_HUMAN | ABHD14A | physical | 28514442 | |
| GPDM_HUMAN | GPD2 | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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