| UniProt ID | LTMD1_HUMAN | |
|---|---|---|
| UniProt AC | Q6P1Q0 | |
| Protein Name | LETM1 domain-containing protein 1 | |
| Gene Name | LETMD1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 360 | |
| Subcellular Localization |
Mitochondrion outer membrane Single-pass membrane protein . |
|
| Protein Description | Involved in tumorigenesis and may function as a negative regulator of the p53/TP53.. | |
| Protein Sequence | MALSRVCWARSAVWGSAVTPGHFVTRRLQLGRSGLAWGAPRSSKLHLSPKADVKNLMSYVVTKTKAINGKYHRFLGRHFPRFYVLYTIFMKGLQMLWADAKKARRIKTNMWKHNIKFHQLPYREMEHLRQFRQDVTKCLFLGIISIPPFANYLVFLLMYLFPRQLLIRHFWTPKQQTDFLDIYHAFRKQSHPEIISYLEKVIPLISDAGLRWRLTDLCTKIQRGTHPAIHDILALRECFSNHPLGMNQLQALHVKALSRAMLLTSYLPPPLLRHRLKTHTTVIHQLDKALAKLGIGQLTAQEVKSACYLRGLNSTHIGEDRCRTWLGEWLQISCSLKEAELSLLLHNVVLLSTNYLGTRR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 48 | Phosphorylation | RSSKLHLSPKADVKN CCCCCCCCCCHHHHH | 17.38 | 23312004 | |
| 50 | Ubiquitination | SKLHLSPKADVKNLM CCCCCCCCHHHHHHH | 54.57 | - | |
| 54 | Ubiquitination | LSPKADVKNLMSYVV CCCCHHHHHHHHHHH | 44.93 | - | |
| 107 | Ubiquitination | AKKARRIKTNMWKHN HHHHHHHHCCCHHHC | 31.84 | - | |
| 183 | Phosphorylation | QTDFLDIYHAFRKQS HCCHHHHHHHHHHCC | 6.17 | - | |
| 196 | Phosphorylation | QSHPEIISYLEKVIP CCCHHHHHHHHHHHH | 29.35 | 28555341 | |
| 197 | Phosphorylation | SHPEIISYLEKVIPL CCHHHHHHHHHHHHH | 14.42 | 28555341 | |
| 264 | Phosphorylation | LSRAMLLTSYLPPPL HHHHHHHHHCCCHHH | 16.03 | - | |
| 265 | Phosphorylation | SRAMLLTSYLPPPLL HHHHHHHHCCCHHHH | 25.33 | - | |
| 277 | Ubiquitination | PLLRHRLKTHTTVIH HHHHHHHHHCHHHHH | 37.91 | - | |
| 288 | Ubiquitination | TVIHQLDKALAKLGI HHHHHHHHHHHHCCC | 54.62 | - | |
| 292 | Ubiquitination | QLDKALAKLGIGQLT HHHHHHHHCCCCCCC | 48.36 | - | |
| 304 | Ubiquitination | QLTAQEVKSACYLRG CCCHHHHHHHHHHCC | 31.42 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of LTMD1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LTMD1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LTMD1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| A4_HUMAN | APP | physical | 21832049 | |
| CPVL_HUMAN | CPVL | physical | 26186194 | |
| RT4I1_HUMAN | RTN4IP1 | physical | 26186194 | |
| RT4I1_HUMAN | RTN4IP1 | physical | 28514442 | |
| CPVL_HUMAN | CPVL | physical | 28514442 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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