RT4I1_HUMAN - dbPTM
RT4I1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RT4I1_HUMAN
UniProt AC Q8WWV3
Protein Name Reticulon-4-interacting protein 1, mitochondrial
Gene Name RTN4IP1
Organism Homo sapiens (Human).
Sequence Length 396
Subcellular Localization Mitochondrion outer membrane . Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.
Protein Description Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury..
Protein Sequence MEFLKTCVLRRNACTAVCFWRSKVVQKPSVRRISTTSPRSTVMPAWVIDKYGKNEVLRFTQNMMMPIIHYPNEVIVKVHAASVNPIDVNMRSGYGATALNMKRDPLHVKIKGEEFPLTLGRDVSGVVMECGLDVKYFKPGDEVWAAVPPWKQGTLSEFVVVSGNEVSHKPKSLTHTQAASLPYVALTAWSAINKVGGLNDKNCTGKRVLILGASGGVGTFAIQVMKAWDAHVTAVCSQDASELVRKLGADDVIDYKSGSVEEQLKSLKPFDFILDNVGGSTETWAPDFLKKWSGATYVTLVTPFLLNMDRLGIADGMLQTGVTVGSKALKHFWKGVHYRWAFFMASGPCLDDIAELVDAGKIRPVIEQTFPFSKVPEAFLKVERGHARGKTVINVV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
34PhosphorylationKPSVRRISTTSPRST
CCCEEEEECCCCCCC		24.6621406692
35PhosphorylationPSVRRISTTSPRSTV
CCEEEEECCCCCCCC		28.9920068231
36PhosphorylationSVRRISTTSPRSTVM
CEEEEECCCCCCCCC		29.9121406692
37PhosphorylationVRRISTTSPRSTVMP
EEEEECCCCCCCCCC		20.5721406692
40O-linked_GlycosylationISTTSPRSTVMPAWV
EECCCCCCCCCCEEE		28.8330379171
53MalonylationWVIDKYGKNEVLRFT
EEEECCCCCHHHHHH		47.0126320211
92PhosphorylationPIDVNMRSGYGATAL
CCCCCCCCCCCCCCC		26.12-
94PhosphorylationDVNMRSGYGATALNM
CCCCCCCCCCCCCCC		12.5822817900
97PhosphorylationMRSGYGATALNMKRD
CCCCCCCCCCCCCCC		27.58-
174PhosphorylationSHKPKSLTHTQAASL
CCCCCCCCHHHHCCC		29.9328387310
214PhosphorylationRVLILGASGGVGTFA
EEEEEECCCCCHHHH		33.99-
246UbiquitinationDASELVRKLGADDVI
CHHHHHHHHCCCCCE		43.7429967540
246MalonylationDASELVRKLGADDVI
CHHHHHHHHCCCCCE		43.7426320211
2462-HydroxyisobutyrylationDASELVRKLGADDVI
CHHHHHHHHCCCCCE		43.74-
256UbiquitinationADDVIDYKSGSVEEQ
CCCCEECCCCCHHHH		44.5929967540
256AcetylationADDVIDYKSGSVEEQ
CCCCEECCCCCHHHH		44.5925038526
293PhosphorylationPDFLKKWSGATYVTL
HHHHHHCCCCCEEEE		27.6820068231
296PhosphorylationLKKWSGATYVTLVTP
HHHCCCCCEEEEHHH		23.2720068231
297PhosphorylationKKWSGATYVTLVTPF
HHCCCCCEEEEHHHH		7.3020068231
299PhosphorylationWSGATYVTLVTPFLL
CCCCCEEEEHHHHHH		12.7120068231
302PhosphorylationATYVTLVTPFLLNMD
CCEEEEHHHHHHCCH		16.0720068231
320PhosphorylationIADGMLQTGVTVGSK
CCCCHHCCCCCCCHH		29.6520068231
323PhosphorylationGMLQTGVTVGSKALK
CHHCCCCCCCHHHHH		22.0920068231
326PhosphorylationQTGVTVGSKALKHFW
CCCCCCCHHHHHHHH		15.4920068231
346PhosphorylationRWAFFMASGPCLDDI
HHHHHHCCCCCHHHH		31.3224719451
369PhosphorylationIRPVIEQTFPFSKVP
CCCCEEECCCHHHCC		22.0820068231
373PhosphorylationIEQTFPFSKVPEAFL
EEECCCHHHCCHHHH		32.7420068231
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RT4I1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RT4I1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RT4I1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BORG4_HUMANCDC42EP4physical
26186194
HEXI1_HUMANHEXIM1physical
26186194
BORG4_HUMANCDC42EP4physical
28514442
HEXI1_HUMANHEXIM1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RT4I1_HUMAN

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Related Literatures of Post-Translational Modification

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