GNPAT_HUMAN - dbPTM
GNPAT_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID GNPAT_HUMAN
UniProt AC O15228
Protein Name Dihydroxyacetone phosphate acyltransferase
Gene Name GNPAT
Organism Homo sapiens (Human).
Sequence Length 680
Subcellular Localization Peroxisome membrane
Peripheral membrane protein
Matrix side. Exclusively localized to the lumenal side of the peroxisomal membrane..
Protein Description
Protein Sequence MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPATAKL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MESSSSSNSYF
----CCCCCCCCCCC		22.4228348404
5Phosphorylation---MESSSSSNSYFS
---CCCCCCCCCCCC		47.2528348404
6Phosphorylation--MESSSSSNSYFSV
--CCCCCCCCCCCCC		35.1728348404
7Phosphorylation-MESSSSSNSYFSVG
-CCCCCCCCCCCCCC		31.5728348404
9PhosphorylationESSSSSNSYFSVGPT
CCCCCCCCCCCCCCC		29.5128348404
10PhosphorylationSSSSSNSYFSVGPTS
CCCCCCCCCCCCCCC		12.2528348404
12PhosphorylationSSSNSYFSVGPTSPS
CCCCCCCCCCCCCHH		20.2428348404
16PhosphorylationSYFSVGPTSPSAVVL
CCCCCCCCCHHHHHH		47.5528348404
17PhosphorylationYFSVGPTSPSAVVLL
CCCCCCCCHHHHHHH		21.7126657352
31UbiquitinationLYSKELKKWDEFEDI
HHCCHHCCCHHHHHH		72.9329967540
48UbiquitinationERRHVSDLKFAMKCY
HHHCHHHHHHHHHCC		3.7123000965
49UbiquitinationRRHVSDLKFAMKCYT
HHCHHHHHHHHHCCC		35.7523000965
52UbiquitinationVSDLKFAMKCYTPLV
HHHHHHHHHCCCCEE		3.2923000965
52UbiquitinationVSDLKFAMKCYTPLV
HHHHHHHHHCCCCEE		3.29-
53UbiquitinationSDLKFAMKCYTPLVY
HHHHHHHHCCCCEEE		22.2123000965
60UbiquitinationKCYTPLVYKGITPCK
HCCCCEEECCCCCCC		15.9223000965
61UbiquitinationCYTPLVYKGITPCKP
CCCCEEECCCCCCCC		36.0423000965
66UbiquitinationVYKGITPCKPIDIKC
EECCCCCCCCCEEEE		6.4823000965
67UbiquitinationYKGITPCKPIDIKCS
ECCCCCCCCCEEEEE		46.3323000965
67AcetylationYKGITPCKPIDIKCS
ECCCCCCCCCEEEEE		46.3325953088
71UbiquitinationTPCKPIDIKCSVLNS
CCCCCCEEEEEECCH		5.1223000965
72UbiquitinationPCKPIDIKCSVLNSE
CCCCCEEEEEECCHH		19.4023000965
75UbiquitinationPIDIKCSVLNSEEIH
CCEEEEEECCHHHHH		9.1032015554
85UbiquitinationSEEIHYVIKQLSKES
HHHHHHHHHHHCHHH		1.53-
85UbiquitinationSEEIHYVIKQLSKES
HHHHHHHHHHHCHHH		1.5323000965
86UbiquitinationEEIHYVIKQLSKESL
HHHHHHHHHHCHHHH		34.8323000965
89UbiquitinationHYVIKQLSKESLQSV
HHHHHHHCHHHHCHH		31.7023000965
90UbiquitinationYVIKQLSKESLQSVD
HHHHHHCHHHHCHHH		60.9723000965
111PhosphorylationSEILDEMSHKLRLGA
HHHHHHHCHHHHHHH		18.54-
112UbiquitinationEILDEMSHKLRLGAI
HHHHHHCHHHHHHHH		31.6821890473
113UbiquitinationILDEMSHKLRLGAIR
HHHHHCHHHHHHHHH		28.1721890473
113UbiquitinationILDEMSHKLRLGAIR
HHHHHCHHHHHHHHH		28.1722817900
128AcetylationFCAFTLSKVFKQIFS
HHHHHHHHHHHHHHH		55.6088343
135PhosphorylationKVFKQIFSKVCVNEE
HHHHHHHHHHCCCHH		26.3024719451
136UbiquitinationVFKQIFSKVCVNEEG
HHHHHHHHHCCCHHH		28.9832015554
142UbiquitinationSKVCVNEEGIQKLQR
HHHCCCHHHHHHHHH		57.2927667366
146UbiquitinationVNEEGIQKLQRAIQE
CCHHHHHHHHHHHHH		44.67-
190UbiquitinationPVIAAGMDFLGMKMV
HHHHCCCCHHHHHHH		34.4027667366
243UbiquitinationAPVEFFLEGTRSRSA
CCEEEEECCCCCCCC		54.0533845483
250UbiquitinationEGTRSRSAKTLTPKF
CCCCCCCCCCCCCCC		14.0327667366
251UbiquitinationGTRSRSAKTLTPKFG
CCCCCCCCCCCCCCC		45.36-
251UbiquitinationGTRSRSAKTLTPKFG
CCCCCCCCCCCCCCC		45.3627667366
275PhosphorylationFKREVFDTYLVPISI
HCCCCCCEEEEEEEE		13.8025262027
276PhosphorylationKREVFDTYLVPISIS
CCCCCCEEEEEEEEC		13.9325262027
281PhosphorylationDTYLVPISISYDKIL
CEEEEEEEECHHHHH		10.2225262027
283PhosphorylationYLVPISISYDKILEE
EEEEEEECHHHHHHH		22.0825262027
284PhosphorylationLVPISISYDKILEET
EEEEEECHHHHHHHH		21.4225262027
291PhosphorylationYDKILEETLYVYELL
HHHHHHHHHHHHHHH		17.64-
304UbiquitinationLLGVPKPKESTTGLL
HHCCCCCCCCCHHHH		71.1233845483
307PhosphorylationVPKPKESTTGLLKAR
CCCCCCCCHHHHHHH		26.4424719451
308PhosphorylationPKPKESTTGLLKARK
CCCCCCCHHHHHHHH		34.8024719451
312UbiquitinationESTTGLLKARKILSE
CCCHHHHHHHHHHHH		51.7129967540
343PhosphorylationSLAAGRMSRSSYNLV
HHHCCCCCCCCCCCC		27.8730622161
345PhosphorylationAAGRMSRSSYNLVPR
HCCCCCCCCCCCCCC		29.8430108239
346PhosphorylationAGRMSRSSYNLVPRY
CCCCCCCCCCCCCCC		19.5530108239
357MalonylationVPRYIPQKQSEDMHA
CCCCCCCCCCCCHHH		50.8926320211
398UbiquitinationAVLLQNRPSMDFDAL
HHHHCCCCCCCHHHH		41.3724816145
446UbiquitinationILLHSNIASLVKDQV
HHHCCCHHHHCCCEE		10.8924816145
447PhosphorylationLLHSNIASLVKDQVI
HHCCCHHHHCCCEEE		29.8724719451
506UbiquitinationLQMTPGFRKEDVYSC
HHCCCCCCHHHHHHH		47.5824816145
507UbiquitinationQMTPGFRKEDVYSCF
HCCCCCCHHHHHHHH		56.8824816145
541PhosphorylationKDFEEGCYLLCKSEA
CCHHHCCEEEECCCC		17.3625147952
545UbiquitinationEGCYLLCKSEAIQVT
HCCEEEECCCCEEEE		51.8329967540
582AcetylationPFVESYQIICKYLLS
HHHHHHHHHHHHHCC		2.79-
582AcetylationPFVESYQIICKYLLS
HHHHHHHHHHHHHCC		2.7919608861
589PhosphorylationIICKYLLSEEEDHFS
HHHHHHCCCCCCCCC		40.13-
606UbiquitinationQYLAAVRKFTSQLLD
HHHHHHHHHHHHHHH		46.5329967540
606AcetylationQYLAAVRKFTSQLLD
HHHHHHHHHHHHHHH		46.5325953088
613UbiquitinationKFTSQLLDQGTSQCY
HHHHHHHHCCCHHHH		54.1529967540
624PhosphorylationSQCYDVLSSDVQKNA
HHHHHHHCHHHHHHH		25.0820068231
625PhosphorylationQCYDVLSSDVQKNAL
HHHHHHCHHHHHHHH		37.3320068231
643MalonylationVRLGVVEKKKINNNC
HHHCCCEEEEECCCC		47.9926320211
643AcetylationVRLGVVEKKKINNNC
HHHCCCEEEEECCCC		47.9919608861
644AcetylationRLGVVEKKKINNNCI
HHCCCEEEEECCCCE		45.4325953088
645MalonylationLGVVEKKKINNNCIF
HCCCEEEEECCCCEE		62.8326320211
665SulfoxidationATTKLEEMLGCKTPI
CCCHHHHHHCCCCCC		2.5921406390
669AcetylationLEEMLGCKTPIGKPA
HHHHHCCCCCCCCCC		56.3825953088
674UbiquitinationGCKTPIGKPATAKL-
CCCCCCCCCCCCCC-		32.0029967540
677PhosphorylationTPIGKPATAKL----
CCCCCCCCCCC----		32.6227732954
679MalonylationIGKPATAKL------
CCCCCCCCC------		50.8332601280
679AcetylationIGKPATAKL------
CCCCCCCCC------		50.8325953088
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of GNPAT_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of GNPAT_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of GNPAT_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
GPR3_HUMANGPR3physical
21988832
Drug and Disease Associations
Kegg Disease
H00207 Rhizomelic chondrodysplasia punctata, including: Rhizomelic chondrodysplasia punctata, type I (RCDP1
OMIM Disease
222765Rhizomelic chondrodysplasia punctata 2 (RCDP2)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of GNPAT_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-643, AND MASS SPECTROMETRY.

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