GPR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GPR3_HUMAN
• UniProt AC: P46089
• Protein Name: G-protein coupled receptor 3
• Gene Name: GPR3
• Organism: Homo sapiens (Human).
• Sequence Length: 330
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity)..
• Protein Sequence: MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	N-linked_Glycosylation	SAGSGNVNVSSVGPA CCCCCCEECEEECCC	31.77	UniProtKB CARBOHYD
39	Phosphorylation	GPAAPLPSPKAWDVV CCCCCCCCCCCCEEE	46.87	24719451
237	Phosphorylation	QRHLLPASHYVATRK HHCCCCHHHHHHHHC	17.26	-
313	S-palmitoylation	KVLWAVCCCCSSSKI HHHHHHHHHCCCCCC	1.79	-
324	Phosphorylation	SSKIPFRSRSPSDV- CCCCCCCCCCCCCC-	37.17	-
326	Phosphorylation	KIPFRSRSPSDV--- CCCCCCCCCCCC---	29.96	-
328	Phosphorylation	PFRSRSPSDV----- CCCCCCCCCC-----	52.86	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GPR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GPR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GPR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TMEM5_HUMAN	TMEM5	physical	21988832
ZN593_HUMAN	ZNF593	physical	21988832
DMWD_HUMAN	DMWD	physical	26186194
DMWD_HUMAN	DMWD	physical	28514442
APOD_HUMAN	APOD	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.