P4K2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P4K2B_HUMAN
• UniProt AC: Q8TCG2
• Protein Name: Phosphatidylinositol 4-kinase type 2-beta
• Gene Name: PI4K2B
• Organism: Homo sapiens (Human).
• Sequence Length: 481
• Subcellular Localization: Cytoplasm. Membrane. Mostly cytoplasmic but also found associated with the plasma membrane, the Golgi and endosomes. Compared to PI4K2A, a larger fraction of PI4K2B is cytosolic due to a smaller extent of palmitoylation. Translocates to membranes whe
• Protein Description: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking..
• Protein Sequence: MEDPSEPDRLASADGGSPEEEEDGEREPLLPRIAWAHPRRGAPGSAVRLLDAAGEEGEAGDEELPLPPGDVGVSRSSSAELDRSRPAVSVTIGTSEMNAFLDDPEFADIMLRAEQAIEVGIFPERISQGSSGSYFVKDPKRKIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLIPNQGYLSEAGAYLVDNKLHLSIVPKTKVVWLVSETFNYNAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVEGYKEAEYWLRKFEADPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVRYEKQKCEKEIDHKESKWIDDEEFLIKIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEEIRNLILPYISDMNFVQDLCEDLYELFKTDKGFDKATFESQMSVMRGQILNLTQALRDGKSPFQLVQIPCVIVERSQGGSQGRIVHLSNSFTQTVNCRKPFFSSW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SEPDRLASADGGSPE CCCCHHHCCCCCCHH	31.33	30278072
17	Phosphorylation	LASADGGSPEEEEDG HHCCCCCCHHHCCCC	34.37	23401153
45	Phosphorylation	PRRGAPGSAVRLLDA CCCCCCCHHHHHHHH	23.64	28102081
78	Phosphorylation	VGVSRSSSAELDRSR CCCCCCCCCCCCCCC	27.32	28857561
133	Phosphorylation	ISQGSSGSYFVKDPK CCCCCCCCEECCCCC	19.83	25884760
134	Phosphorylation	SQGSSGSYFVKDPKR CCCCCCCEECCCCCC	18.86	22817900
137	Ubiquitination	SSGSYFVKDPKRKII CCCCEECCCCCCCEE	59.42	21890473
140	Ubiquitination	SYFVKDPKRKIIGVF CEECCCCCCCEEEEE	76.18	-
142	Ubiquitination	FVKDPKRKIIGVFKP ECCCCCCCEEEEECC	44.81	-
148	Ubiquitination	RKIIGVFKPKSEEPY CCEEEEECCCCCCCC	49.48	-
150	Ubiquitination	IIGVFKPKSEEPYGQ EEEEECCCCCCCCCC	71.71	-
155	Phosphorylation	KPKSEEPYGQLNPKW CCCCCCCCCCCCHHH	22.30	28102081
161	Ubiquitination	PYGQLNPKWTKYVHK CCCCCCHHHHHHHHH	67.43	21890473
164	Ubiquitination	QLNPKWTKYVHKVCC CCCHHHHHHHHHCCC	44.13	-
168	Ubiquitination	KWTKYVHKVCCPCCF HHHHHHHHCCCCCCC	27.24	-
170	S-palmitoylation	TKYVHKVCCPCCFGR HHHHHHCCCCCCCCC	2.27	17927563
171	S-palmitoylation	KYVHKVCCPCCFGRG HHHHHCCCCCCCCCC	3.02	17927563
173	S-palmitoylation	VHKVCCPCCFGRGCL HHHCCCCCCCCCCCC	1.55	17927563
174	S-palmitoylation	HKVCCPCCFGRGCLI HHCCCCCCCCCCCCC	2.15	17927563
198	Ubiquitination	GAYLVDNKLHLSIVP CEEEECCCEEEEECC	32.59	-
232	Phosphorylation	AKSRGKKYALEKVPK HHHCCCCHHHHHCCC	21.65	29496907
236	Ubiquitination	GKKYALEKVPKVGRK CCCHHHHHCCCCCCC	65.76	-
272	Ubiquitination	EAEYWLRKFEADPLP HHHHHHHHCCCCCCC	45.44	21890473
284	Ubiquitination	PLPENIRKQFQSQFE CCCHHHHHHHHHHHH	52.22	-
298	Phosphorylation	ERLVILDYIIRNTDR HHHHHHHHHHHCCCC	8.53	24670416
326	Ubiquitination	CEKEIDHKESKWIDD CHHHCCCCHHCCCCC	60.99	-
329	Ubiquitination	EIDHKESKWIDDEEF HCCCCHHCCCCCHHH	49.62	-
352	Ubiquitination	NGLAFPFKHPDEWRA CCEEECCCCCCCCCC	55.24	21890473
411	Ubiquitination	KTDKGFDKATFESQM HHCCCCCHHHHHHHH	47.25	21890473
436	Ubiquitination	TQALRDGKSPFQLVQ HHHHHCCCCCCEEEE	60.28	-
464	Phosphorylation	QGRIVHLSNSFTQTV CCEEEEECCCCCCEE	18.62	21712546
466	Phosphorylation	RIVHLSNSFTQTVNC EEEEECCCCCCEECC	26.71	23401153
468	Phosphorylation	VHLSNSFTQTVNCRK EEECCCCCCEECCCC	24.13	23911959
470	Phosphorylation	LSNSFTQTVNCRKPF ECCCCCCEECCCCCC	15.61	23403867
475	Ubiquitination	TQTVNCRKPFFSSW- CCEECCCCCCCCCC-	48.67	-
480	Phosphorylation	CRKPFFSSW------ CCCCCCCCC------	31.48	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P4K2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P4K2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of P4K2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS90A_HUMAN	HSP90AA1	physical	21330372

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale proteomics analysis of the human kinome.";
Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.;
Mol. Cell. Proteomics 8:1751-1764(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-17 AND SER-45,AND MASS SPECTROMETRY.
PubMed: 19369195