NDUB5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB5_HUMAN
• UniProt AC: O43674
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial
• Gene Name: NDUFB5
• Organism: Homo sapiens (Human).
• Sequence Length: 189
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAAMSLLRRVSVTAVAALSGRPLGTRLGFGGFLTRGFPKAAAPVRHSGDHGKRLFVIRPSRFYDRRFLKLLRFYIALTGIPVAIFITLVNVFIGQAELAEIPEGYVPEHWEYYKHPISRWIARNFYDSPEKIYERTMAVLQIEAEKAELRVKELEVRKLMHVRGDGPWYYYETIDKELIDHSPKATPDN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAAMSLLRRVSV ---CCHHHHHHHHHH	21.37	24043423
34	Phosphorylation	LGFGGFLTRGFPKAA ECCCCCCCCCCCCCC	26.87	22210691
39	Ubiquitination	FLTRGFPKAAAPVRH CCCCCCCCCCCCCEE	48.69	-
126	Phosphorylation	RWIARNFYDSPEKIY HHHHHHCCCCHHHHH	21.04	29214152
128	Phosphorylation	IARNFYDSPEKIYER HHHHCCCCHHHHHHH	24.47	21815630
131	Ubiquitination	NFYDSPEKIYERTMA HCCCCHHHHHHHHHH	54.71	-
131	Acetylation	NFYDSPEKIYERTMA HCCCCHHHHHHHHHH	54.71	27452117
133	Phosphorylation	YDSPEKIYERTMAVL CCCHHHHHHHHHHHH	15.49	29496907
146	Acetylation	VLQIEAEKAELRVKE HHHHHHHHHCCEEEE	54.96	26822725
152	Ubiquitination	EKAELRVKELEVRKL HHHCCEEEEEEEEEE	50.58	-
152	2-Hydroxyisobutyrylation	EKAELRVKELEVRKL HHHCCEEEEEEEEEE	50.58	-
176	Ubiquitination	YYYETIDKELIDHSP EEEEECCHHHHCCCC	51.04	-
182	Phosphorylation	DKELIDHSPKATPDN CHHHHCCCCCCCCCC	25.09	25159151
184	Acetylation	ELIDHSPKATPDN-- HHHCCCCCCCCCC--	68.83	27452117

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUB5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NDUB9_HUMAN	NDUFB9	physical	22939629
NDUS1_HUMAN	NDUFS1	physical	22939629
NDUS4_HUMAN	NDUFS4	physical	22939629
NDUS7_HUMAN	NDUFS7	physical	22939629
RT26_HUMAN	MRPS26	physical	22939629
AT5F1_HUMAN	ATP5F1	physical	26344197
EIF3I_HUMAN	EIF3I	physical	26344197
MTCH2_HUMAN	MTCH2	physical	26344197
NDUS1_HUMAN	NDUFS1	physical	26344197
QCR2_HUMAN	UQCRC2	physical	26344197
ECSIT_HUMAN	ECSIT	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
NDUB7_HUMAN	NDUFB7	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NCALD_HUMAN	NCALD	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
NDUA8_HUMAN	NDUFA8	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NDUS3_HUMAN	NDUFS3	physical	28514442
NDUS7_HUMAN	NDUFS7	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
F174A_HUMAN	FAM174A	physical	28514442
NDUBA_HUMAN	NDUFB10	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
PSMG3_HUMAN	PSMG3	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.