NDUB3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUB3_HUMAN
• UniProt AC: O43676
• Protein Name: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3
• Gene Name: NDUFB3
• Organism: Homo sapiens (Human).
• Sequence Length: 98
• Subcellular Localization: Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MAHEHGHEHGHHKMELPDYRQWKIEGTPLETIQKKLAAKGLRDPWGRNEAWRYMGGFAKSVSFSDVFFKGFKWGFAAFVVAVGAEYYLESLNKDKKHH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAHEHGHEH ------CCCCCCCCC	19.44	-
5	Methylation	---MAHEHGHEHGHH ---CCCCCCCCCCCC	32.80	-
7	Methylation	-MAHEHGHEHGHHKM -CCCCCCCCCCCCCC	26.28	-
9	Methylation	AHEHGHEHGHHKMEL CCCCCCCCCCCCCCC	34.90	-
23	Acetylation	LPDYRQWKIEGTPLE CCCHHHCCCCCCCHH	23.65	26051181
23	Succinylation	LPDYRQWKIEGTPLE CCCHHHCCCCCCCHH	23.65	-
23	Succinylation	LPDYRQWKIEGTPLE CCCHHHCCCCCCCHH	23.65	-
23	Ubiquitination	LPDYRQWKIEGTPLE CCCHHHCCCCCCCHH	23.65	-
34	Acetylation	TPLETIQKKLAAKGL CCHHHHHHHHHHCCC	46.00	23236377
34	Succinylation	TPLETIQKKLAAKGL CCHHHHHHHHHHCCC	46.00	-
34	Succinylation	TPLETIQKKLAAKGL CCHHHHHHHHHHCCC	46.00	27452117
34	Malonylation	TPLETIQKKLAAKGL CCHHHHHHHHHHCCC	46.00	26320211
35	Acetylation	PLETIQKKLAAKGLR CHHHHHHHHHHCCCC	27.30	30584103
39	Methylation	IQKKLAAKGLRDPWG HHHHHHHCCCCCCCC	53.52	-
39	Trimethylation	IQKKLAAKGLRDPWG HHHHHHHCCCCCCCC	53.52	-
59	Methylation	RYMGGFAKSVSFSDV HHHHCCCCCCCHHHH	49.48	115973815
60	Phosphorylation	YMGGFAKSVSFSDVF HHHCCCCCCCHHHHH	21.40	22673903
62	Phosphorylation	GGFAKSVSFSDVFFK HCCCCCCCHHHHHHC	26.56	22673903
64	Phosphorylation	FAKSVSFSDVFFKGF CCCCCCHHHHHHCCC	25.92	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUB3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUB3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUB3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.