NDUA8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NDUA8_HUMAN
• UniProt AC: P51970
• Protein Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8
• Gene Name: NDUFA8
• Organism: Homo sapiens (Human).
• Sequence Length: 172
• Subcellular Localization: Mitochondrion inner membrane ; Peripheral membrane protein . Mitochondrion intermembrane space . Mitochondrion .
• Protein Description: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone..
• Protein Sequence: MPGIVELPTLEELKVDEVKISSAVLKAAAHHYGAQCDKPNKEFMLCRWEEKDPRRCLEEGKLVNKCALDFFRQIKRHCAEPFTEYWTCIDYTGQQLFRHCRKQQAKFDECVLDKLGWVRPDLGELSKVTKVKTDRPLPENPYHSRPRPDPSPEIEGDLQPATHGSRFYFWTK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Ubiquitination	LPTLEELKVDEVKIS CCCHHHCCCCEEECC	51.42	-
19	Ubiquitination	ELKVDEVKISSAVLK HCCCCEEECCHHHHH	34.52	21890473
19	Ubiquitination	ELKVDEVKISSAVLK HCCCCEEECCHHHHH	34.52	21890473
19	2-Hydroxyisobutyrylation	ELKVDEVKISSAVLK HCCCCEEECCHHHHH	34.52	-
26	Ubiquitination	KISSAVLKAAAHHYG ECCHHHHHHHHHHHC	29.40	-
38	Acetylation	HYGAQCDKPNKEFML HHCCCCCCCCCCEEE	59.10	25825284
38	Ubiquitination	HYGAQCDKPNKEFML HHCCCCCCCCCCEEE	59.10	-
41	Acetylation	AQCDKPNKEFMLCRW CCCCCCCCCEEEEEC	61.94	26051181
41	Ubiquitination	AQCDKPNKEFMLCRW CCCCCCCCCEEEEEC	61.94	-
51	Ubiquitination	MLCRWEEKDPRRCLE EEEECCCCCHHHHHH	62.61	-
51	Acetylation	MLCRWEEKDPRRCLE EEEECCCCCHHHHHH	62.61	26051181
61	Acetylation	RRCLEEGKLVNKCAL HHHHHHCCHHHHHHH	53.17	26051181
61	Ubiquitination	RRCLEEGKLVNKCAL HHHHHHCCHHHHHHH	53.17	21890473
65	Acetylation	EEGKLVNKCALDFFR HHCCHHHHHHHHHHH	17.26	25953088
65	Ubiquitination	EEGKLVNKCALDFFR HHCCHHHHHHHHHHH	17.26	21890473
65	Ubiquitination	EEGKLVNKCALDFFR HHCCHHHHHHHHHHH	17.26	21890473
85	Phosphorylation	CAEPFTEYWTCIDYT CCCCCCCCEEHHCHH	11.71	29496907
91	Phosphorylation	EYWTCIDYTGQQLFR CCEEHHCHHHHHHHH	7.89	29496907
102	Ubiquitination	QLFRHCRKQQAKFDE HHHHHHHHHHHCCCH	52.75	21890473
106	Ubiquitination	HCRKQQAKFDECVLD HHHHHHHCCCHHHHH	49.35	21890473
106	Ubiquitination	HCRKQQAKFDECVLD HHHHHHHCCCHHHHH	49.35	21890473
114	Acetylation	FDECVLDKLGWVRPD CCHHHHHHHCCCCCC	44.75	25038526
114	Ubiquitination	FDECVLDKLGWVRPD CCHHHHHHHCCCCCC	44.75	-
127	Ubiquitination	PDLGELSKVTKVKTD CCHHHHHCCEECCCC	67.55	21890473
132	Ubiquitination	LSKVTKVKTDRPLPE HHCCEECCCCCCCCC	46.38	-
142	Phosphorylation	RPLPENPYHSRPRPD CCCCCCCCCCCCCCC	24.82	27196784
151	Phosphorylation	SRPRPDPSPEIEGDL CCCCCCCCCCCCCCC	42.41	29255136
168	Phosphorylation	ATHGSRFYFWTK--- CCCCCCEEEEEC---	9.33	27642862

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NDUA8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NDUA8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NDUA8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KDM1A_HUMAN	KDM1A	physical	23455924
NDUB1_HUMAN	NDUFB1	physical	26186194
NDUV2_HUMAN	NDUFV2	physical	26186194
NDUV3_HUMAN	NDUFV3	physical	26186194
KCC2B_HUMAN	CAMK2B	physical	26186194
KCC2G_HUMAN	CAMK2G	physical	26186194
KCC2D_HUMAN	CAMK2D	physical	26186194
NU4M_HUMAN	ND4	physical	26186194
CIA30_HUMAN	NDUFAF1	physical	26186194
NDUA7_HUMAN	NDUFA7	physical	26186194
NDUB9_HUMAN	NDUFB9	physical	26186194
NDUA2_HUMAN	NDUFA2	physical	26186194
NDUS2_HUMAN	NDUFS2	physical	26186194
NDUA3_HUMAN	NDUFA3	physical	26186194
NDUS1_HUMAN	NDUFS1	physical	26186194
NDUB8_HUMAN	NDUFB8	physical	26186194
NDUS4_HUMAN	NDUFS4	physical	26186194
NDUS6_HUMAN	NDUFS6	physical	26186194
ACAD9_HUMAN	ACAD9	physical	26186194
NDUA9_HUMAN	NDUFA9	physical	26186194
NDUAC_HUMAN	NDUFA12	physical	26186194
NDUV1_HUMAN	NDUFV1	physical	26186194
NU1M_HUMAN	ND1	physical	26186194
NDUB7_HUMAN	NDUFB7	physical	26186194
NDUB3_HUMAN	NDUFB3	physical	26186194
NDUS7_HUMAN	NDUFS7	physical	26186194
NDUB4_HUMAN	NDUFB4	physical	26186194
NU5M_HUMAN	ND5	physical	26186194
NDUC2_HUMAN	NDUFC2	physical	26186194
NDUB6_HUMAN	NDUFB6	physical	26186194
NDUS8_HUMAN	NDUFS8	physical	26186194
NDUB5_HUMAN	NDUFB5	physical	26186194
WAPL_HUMAN	WAPAL	physical	26186194
NDUA1_HUMAN	NDUFA1	physical	26186194
CHCH2_HUMAN	CHCHD2	physical	26344197
HSDL2_HUMAN	HSDL2	physical	26344197
NDUV3_HUMAN	NDUFV3	physical	28514442
NDUAC_HUMAN	NDUFA12	physical	28514442
NDUS4_HUMAN	NDUFS4	physical	28514442
NU4M_HUMAN	ND4	physical	28514442
NU5M_HUMAN	ND5	physical	28514442
NDUB8_HUMAN	NDUFB8	physical	28514442
NDUA7_HUMAN	NDUFA7	physical	28514442
NDUB7_HUMAN	NDUFB7	physical	28514442
NDUB9_HUMAN	NDUFB9	physical	28514442
NDUB6_HUMAN	NDUFB6	physical	28514442
NU1M_HUMAN	ND1	physical	28514442
NDUB3_HUMAN	NDUFB3	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
NDUA3_HUMAN	NDUFA3	physical	28514442
NDUV2_HUMAN	NDUFV2	physical	28514442
NDUC2_HUMAN	NDUFC2	physical	28514442
NDUV1_HUMAN	NDUFV1	physical	28514442
NDUB1_HUMAN	NDUFB1	physical	28514442
KCC2B_HUMAN	CAMK2B	physical	28514442
KCC2G_HUMAN	CAMK2G	physical	28514442
WAPL_HUMAN	WAPAL	physical	28514442
JOS2_HUMAN	JOSD2	physical	28514442
NDUS1_HUMAN	NDUFS1	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
NDUA9_HUMAN	NDUFA9	physical	28514442
NDUA1_HUMAN	NDUFA1	physical	28514442
NDUS2_HUMAN	NDUFS2	physical	28514442
NDUS8_HUMAN	NDUFS8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.