HSDL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HSDL2_HUMAN
• UniProt AC: Q6YN16
• Protein Name: Hydroxysteroid dehydrogenase-like protein 2
• Gene Name: HSDL2
• Organism: Homo sapiens (Human).
• Sequence Length: 418
• Subcellular Localization: Peroxisome .
• Protein Description: Has apparently no steroid dehydrogenase activity..
• Protein Sequence: MLPNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIEAVGGKALPCIVDVRDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKRLDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKSFTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVKATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNARL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	TGRLAGCTVFITGAS CCCCCCCEEEEEECC	19.96	22210691
24	2-Hydroxyisobutyrylation	GASRGIGKAIALKAA ECCCCHHHHHHHHHH	34.40	-
29	Methylation	IGKAIALKAAKDGAN HHHHHHHHHHCCCCC	36.96	115971031
29	2-Hydroxyisobutyrylation	IGKAIALKAAKDGAN HHHHHHHHHHCCCCC	36.96	-
32	Acetylation	AIALKAAKDGANIVI HHHHHHHCCCCCEEE	62.65	26051181
32	Succinylation	AIALKAAKDGANIVI HHHHHHHCCCCCEEE	62.65	23954790
42	Acetylation	ANIVIAAKTAQPHPK CCEEEEEECCCCCHH	35.06	25953088
42	Succinylation	ANIVIAAKTAQPHPK CCEEEEEECCCCCHH	35.06	27452117
42	Malonylation	ANIVIAAKTAQPHPK CCEEEEEECCCCCHH	35.06	26320211
42	2-Hydroxyisobutyrylation	ANIVIAAKTAQPHPK CCEEEEEECCCCCHH	35.06	-
49 (in isoform 2)	Ubiquitination	-	54.00	21890473
49 (in isoform 1)	Ubiquitination	-	54.00	21890473
49	2-Hydroxyisobutyrylation	KTAQPHPKLLGTIYT ECCCCCHHHHHHHHH	54.00	-
49	Acetylation	KTAQPHPKLLGTIYT ECCCCCHHHHHHHHH	54.00	23954790
49	Ubiquitination	KTAQPHPKLLGTIYT ECCCCCHHHHHHHHH	54.00	21890473
53	Phosphorylation	PHPKLLGTIYTAAEE CCHHHHHHHHHHHHH	15.69	-
55	Phosphorylation	PKLLGTIYTAAEEIE HHHHHHHHHHHHHHH	7.08	-
56	Phosphorylation	KLLGTIYTAAEEIEA HHHHHHHHHHHHHHH	18.62	-
87	Malonylation	QISAAVEKAIKKFGG HHHHHHHHHHHHHCC	49.14	26320211
87	Ubiquitination	QISAAVEKAIKKFGG HHHHHHHHHHHHHCC	49.14	-
87	Acetylation	QISAAVEKAIKKFGG HHHHHHHHHHHHHCC	49.14	23236377
87	Succinylation	QISAAVEKAIKKFGG HHHHHHHHHHHHHCC	49.14	27452117
103	Phosphorylation	DILVNNASAISLTNT EEEECCCCHHHHCCC	28.40	20873877
106	Phosphorylation	VNNASAISLTNTLDT ECCCCHHHHCCCCCC	28.94	20873877
108	Phosphorylation	NASAISLTNTLDTPT CCCHHHHCCCCCCCC	21.26	20873877
110	Phosphorylation	SAISLTNTLDTPTKR CHHHHCCCCCCCCCH	22.30	20873877
113	Phosphorylation	SLTNTLDTPTKRLDL HHCCCCCCCCCHHEE	35.65	20873877
115	Phosphorylation	TNTLDTPTKRLDLMM CCCCCCCCCHHEEEE	30.78	20873877
116	Acetylation	NTLDTPTKRLDLMMN CCCCCCCCHHEEEEC	52.76	26051181
126	Phosphorylation	DLMMNVNTRGTYLAS EEEECCCCCHHHHHH	26.62	20873877
129	Phosphorylation	MNVNTRGTYLASKAC ECCCCCHHHHHHHHH	16.45	29978859
130	Phosphorylation	NVNTRGTYLASKACI CCCCCHHHHHHHHHH	11.77	29978859
133	Phosphorylation	TRGTYLASKACIPYL CCHHHHHHHHHHHHH	20.42	29978859
141	Acetylation	KACIPYLKKSKVAHI HHHHHHHCCCCEEEE	49.51	25953088
141	Succinylation	KACIPYLKKSKVAHI HHHHHHHCCCCEEEE	49.51	23954790
152	Phosphorylation	VAHILNISPPLNLNP EEEECCCCCCCCCCC	21.28	-
163	Methylation	NLNPVWFKQHCAYTI CCCCHHHHHHHHHHH	24.34	115971015
163	Acetylation	NLNPVWFKQHCAYTI CCCCHHHHHHHHHHH	24.34	26051181
172	Methylation	HCAYTIAKYGMSMYV HHHHHHHHHHHHHHH	38.19	115971023
218	Glutathionylation	GPGIESQCRKVDIIA CCCHHHHHCCHHHHH	6.73	22555962
234	Acetylation	AAYSIFQKPKSFTGN HHHHHHCCCCCCCCC	43.60	26051181
236	Ubiquitination	YSIFQKPKSFTGNFV HHHHCCCCCCCCCEE	66.30	-
237	Phosphorylation	SIFQKPKSFTGNFVI HHHCCCCCCCCCEEE	36.25	23403867
239	Phosphorylation	FQKPKSFTGNFVIDE HCCCCCCCCCEEECC	38.00	23403867
263	Ubiquitination	NFDVYAIKPGHPLQP CEEEEEECCCCCCCC	36.45	-
277	Phosphorylation	PDFFLDEYPEAVSKK CCCCCCCCHHHHHHH	13.16	27762562
283	2-Hydroxyisobutyrylation	EYPEAVSKKVESTGA CCHHHHHHHHHHCCC	54.99	-
283	Ubiquitination	EYPEAVSKKVESTGA CCHHHHHHHHHHCCC	54.99	-
284	Acetylation	YPEAVSKKVESTGAV CHHHHHHHHHHCCCC	43.67	26051181
287	Phosphorylation	AVSKKVESTGAVPEF HHHHHHHHCCCCCCH	34.82	25849741
288	Phosphorylation	VSKKVESTGAVPEFK HHHHHHHCCCCCCHH	18.69	20860994
295	Acetylation	TGAVPEFKEEKLQLQ CCCCCCHHHHHHCCC	64.40	25953088
298	Ubiquitination	VPEFKEEKLQLQPKP CCCHHHHHHCCCCCC	42.50	-
304	Succinylation	EKLQLQPKPRSGAVE HHHCCCCCCCCCCHH	39.85	27452117
304	Ubiquitination	EKLQLQPKPRSGAVE HHHCCCCCCCCCCHH	39.85	-
307	Phosphorylation	QLQPKPRSGAVEETF CCCCCCCCCCHHHHH	39.36	28258704
318	Succinylation	EETFRIVKDSLSDDV HHHHHHHHHCCCHHH	38.95	-
318	Succinylation	EETFRIVKDSLSDDV HHHHHHHHHCCCHHH	38.95	-
318	Ubiquitination	EETFRIVKDSLSDDV HHHHHHHHHCCCHHH	38.95	-
318	2-Hydroxyisobutyrylation	EETFRIVKDSLSDDV HHHHHHHHHCCCHHH	38.95	-
320	Phosphorylation	TFRIVKDSLSDDVVK HHHHHHHCCCHHHHH	24.85	22798277
322	Phosphorylation	RIVKDSLSDDVVKAT HHHHHCCCHHHHHHH	35.40	28258704
383	Acetylation	FVKMFSGKLKPTMAF HHHHHCCCCCCCEEH	52.73	25953088
385	Malonylation	KMFSGKLKPTMAFMS HHHCCCCCCCEEHHC	41.76	26320211
385	Acetylation	KMFSGKLKPTMAFMS HHHCCCCCCCEEHHC	41.76	25953088
394	Acetylation	TMAFMSGKLKIKGNM CEEHHCCCEEEECHH	39.02	25953088
406	Acetylation	GNMALAIKLEKLMNQ CHHHHHHHHHHHHHH	45.01	26051181
409	2-Hydroxyisobutyrylation	ALAIKLEKLMNQMNA HHHHHHHHHHHHHHH	64.57	-
409	Acetylation	ALAIKLEKLMNQMNA HHHHHHHHHHHHHHH	64.57	23236377
409	Succinylation	ALAIKLEKLMNQMNA HHHHHHHHHHHHHHH	64.57	27452117
409	Malonylation	ALAIKLEKLMNQMNA HHHHHHHHHHHHHHH	64.57	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HSDL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HSDL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
49	Ubiquitination	44 (5)	A ⇒ T;P	rs184202621	Epstein-Barr virus copy number in lymphoblastoid cell lines	28654678
49	Ubiquitination	44 (5)	A ⇒ T;P	rs184202621	Epstein-Barr virus copy number in lymphoblastoid cell lines	28654678

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SF01_HUMAN	SF1	physical	26344197
TAGL2_HUMAN	TAGLN2	physical	26344197
TRAP1_HUMAN	TRAP1	physical	26344197
MIPEP_HUMAN	MIPEP	physical	28514442
HERC2_HUMAN	HERC2	physical	28514442
NEUL4_HUMAN	NEURL4	physical	28514442
NPS3A_HUMAN	NIPSNAP3A	physical	28514442
DNJC9_HUMAN	DNAJC9	physical	27173435
XRCC4_HUMAN	XRCC4	physical	27173435
DNPEP_HUMAN	DNPEP	physical	27173435
KIF3A_HUMAN	KIF3A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.