DNJC9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DNJC9_HUMAN
• UniProt AC: Q8WXX5
• Protein Name: DnaJ homolog subfamily C member 9
• Gene Name: DNAJC9
• Organism: Homo sapiens (Human).
• Sequence Length: 260
• Subcellular Localization: Nucleus . Cytoplasm . Cell membrane . Predominantly nuclear. Translocates to the cytoplasm and membrane after heat shock.
• Protein Description: May play a role as co-chaperone of the Hsp70 family proteins HSPA1A, HSPA1B and HSPA8..
• Protein Sequence: MGLLDLCEEVFGTADLYRVLGVRREASDGEVRRGYHKVSLQVHPDRVGEGDKEDATRRFQILGKVYSVLSDREQRAVYDEQGTVDEDSPVLTQDRDWEAYWRLLFKKISLEDIQAFEKTYKGSEEELADIKQAYLDFKGDMDQIMESVLCVQYTEEPRIRNIIQQAIDAGEVPSYNAFVKESKQKMNARKRRAQEEAKEAEMSRKELGLDEGVDSLKAAIQSRQKDRQKEMDNFLAQMEAKYCKSSKGGGKKSALKKEKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
37	Ubiquitination	EVRRGYHKVSLQVHP CEECCEEEEEEEECC	25.65	-
39	Phosphorylation	RRGYHKVSLQVHPDR ECCEEEEEEEECCCC	20.21	22985185
46	Methylation	SLQVHPDRVGEGDKE EEEECCCCCCCCCHH	42.67	-
72	Methylation	VYSVLSDREQRAVYD HHHHCCCHHHHHHHC	38.27	-
88	Phosphorylation	QGTVDEDSPVLTQDR CCCCCCCCCCCCCCC	18.17	26714015
92	Phosphorylation	DEDSPVLTQDRDWEA CCCCCCCCCCCCHHH	28.76	-
95	Methylation	SPVLTQDRDWEAYWR CCCCCCCCCHHHHHH	40.92	-
107	Ubiquitination	YWRLLFKKISLEDIQ HHHHHHHCCCHHHHH	30.14	-
109	Phosphorylation	RLLFKKISLEDIQAF HHHHHCCCHHHHHHH	34.29	23927012
118	Ubiquitination	EDIQAFEKTYKGSEE HHHHHHHHHHCCCHH	51.18	-
121	Ubiquitination	QAFEKTYKGSEEELA HHHHHHHCCCHHHHH	62.28	-
121	Ubiquitination	QAFEKTYKGSEEELA HHHHHHHCCCHHHHH	62.28	-
131	Ubiquitination	EEELADIKQAYLDFK HHHHHHHHHHHHHCC	29.44	-
180	Ubiquitination	PSYNAFVKESKQKMN CCHHHHHHHHHHHHH	50.22	-
183	Ubiquitination	NAFVKESKQKMNARK HHHHHHHHHHHHHHH	55.84	-
205	Ubiquitination	KEAEMSRKELGLDEG HHHHHHHHHHCCCHH	50.40	-
205	Ubiquitination	KEAEMSRKELGLDEG HHHHHHHHHHCCCHH	50.40	-
205	Acetylation	KEAEMSRKELGLDEG HHHHHHHHHHCCCHH	50.40	30588283
215	Phosphorylation	GLDEGVDSLKAAIQS CCCHHHHHHHHHHHH	29.39	17287340
217	Ubiquitination	DEGVDSLKAAIQSRQ CHHHHHHHHHHHHHH	39.46	21906983
217	Ubiquitination	DEGVDSLKAAIQSRQ CHHHHHHHHHHHHHH	39.46	-
217	Methylation	DEGVDSLKAAIQSRQ CHHHHHHHHHHHHHH	39.46	-
229	Ubiquitination	SRQKDRQKEMDNFLA HHHHHHHHHHHHHHH	56.77	-
241	Ubiquitination	FLAQMEAKYCKSSKG HHHHHHHHHHHHCCC	37.56	-
253	Phosphorylation	SKGGGKKSALKKEKK CCCCCCHHHCHHCCC	42.17	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DNJC9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DNJC9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DNJC9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FCL_HUMAN	TSTA3	physical	22939629
HYOU1_HUMAN	HYOU1	physical	26344197
KIF3A_HUMAN	KIF3A	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-109, AND MASSSPECTROMETRY.
PubMed: 18669648

"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry.";
Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.;
Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-215, AND MASSSPECTROMETRY.
PubMed: 17287340