dbPTM

HERC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	HERC2_HUMAN
UniProt AC	O95714
Protein Name	E3 ubiquitin-protein ligase HERC2
Gene Name	HERC2 {ECO:0000312\|EMBL:AAD08657.1}
Organism	Homo sapiens (Human).
Sequence Length	4834
Subcellular Localization	Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Recruited to sites of DNA damage in response to ionizing radiation (IR) via its interaction with RNF8. May loose association with centrosomes during mi
Protein Description	E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. [PubMed: 26692333]
Protein Sequence	MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPPRKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLVKEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKKSSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASLFDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQRGTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDMHLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKGSLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSEWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQLHAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPTAEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIEAKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIASQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSPELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVSIVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQNCRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVALEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYLAMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSHRRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLLLCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGRSYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVPKKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYKWLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLASKNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAVQNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGANNLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSGPELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGKEGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGVHAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVCGALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKLFDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWNGLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLGGQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPMLSVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLRQILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDKQELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALPIVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVSDEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCCRAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIKIGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVPSIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFCGRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWIRLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLNDCTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNSGSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPAAMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSLLIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVATDSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDGVNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSDRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRKLLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQLLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDEVAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGPSVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGTKSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHTHITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRDFVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIALTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
16	Phosphorylation	AAQARLDSKWLKTDI HHHHHHCCCCCHHHH	30.26	25137130
17	Ubiquitination	AQARLDSKWLKTDIQ HHHHHCCCCCHHHHH	57.10	-
20	Ubiquitination	RLDSKWLKTDIQLAF HHCCCCCHHHHHHHH	42.93	-
65	Phosphorylation	LPPRKDDSVEPSGTK CCCCCCCCCCCCCCC	38.21	28985074
72	Ubiquitination	SVEPSGTKKEDLNDK CCCCCCCCHHHCCCH	58.66	21890473
73	Ubiquitination	VEPSGTKKEDLNDKE CCCCCCCHHHCCCHH	57.19	-
79	Ubiquitination	KKEDLNDKEKKDEEE CHHHCCCHHHCCCCC	71.06	-
95	Ubiquitination	PAPIYRAKSILDSWV CCCHHHHHHHHHHHH	29.09	21890473
105	Ubiquitination	LDSWVWGKQPDVNEL HHHHHHCCCCCHHHH	42.84	21890473
113	Ubiquitination	QPDVNELKECLSVLV CCCHHHHHHHHHHHH	39.96	-
136	Phosphorylation	QSATTTLSALRLKQR HCHHCHHHHHHHHHH	24.14	24719451
263	Phosphorylation	RATRFLRSVVTGDVH HHHHHHHHHHHCCCC	24.08	29396449
266	Phosphorylation	RFLRSVVTGDVHGTP HHHHHHHHCCCCCCC	26.05	23186163
272	Phosphorylation	VTGDVHGTPATKGPG HHCCCCCCCCCCCCC	8.55	28985074
275	Phosphorylation	DVHGTPATKGPGSIP CCCCCCCCCCCCCCC	37.42	29396449
276	Ubiquitination	VHGTPATKGPGSIPL CCCCCCCCCCCCCCC	66.28	-
333	Phosphorylation	NERSAQGTSAPLLPL CCCCCCCCCCCHHHH	15.05	23403867
334	Phosphorylation	ERSAQGTSAPLLPLL CCCCCCCCCCHHHHH	34.41	23403867
351	Ubiquitination	FQSIICRKDAPHSEG HHHHHCCCCCCCCCC	54.56	-
364	Phosphorylation	EGDMHLLSGPLSPNE CCCCCCCCCCCCCCC	44.73	25850435
368	Phosphorylation	HLLSGPLSPNESFLR CCCCCCCCCCCCHHH	28.90	22617229
372	Phosphorylation	GPLSPNESFLRYLTL CCCCCCCCHHHHHCC	35.90	25850435
376	Phosphorylation	PNESFLRYLTLPQDN CCCCHHHHHCCCCCC	13.24	22817900
405	Phosphorylation	AHLDRLATPCMPPLC HHHHHHCCCCCCCCC	22.93	-
547	Ubiquitination	VISAFSGKQAGKHVV EEEECCCCCCCCEEE	35.46	-
647	Phosphorylation	GGSDGCKTPKLIEKL CCCCCCCCHHHHHHH	29.72	21406692
649	Acetylation	SDGCKTPKLIEKLQD CCCCCCHHHHHHHCC	68.29	25953088
653	Ubiquitination	KTPKLIEKLQDLDVV CCHHHHHHHCCCCEE	44.44	-
661	Ubiquitination	LQDLDVVKVRCGSQF HCCCCEEEEECCCEE	24.66	-
669	Phosphorylation	VRCGSQFSIALTKDG EECCCEEEEEEECCC	10.18	23612710
683	Ubiquitination	GQVYSWGKGDNQRLG CCEEEECCCCCCCCC	57.75	-
709	Ubiquitination	LLEGLQGKKVIDVAA HHHHHCCCCEEEECC	30.79	-
748	Phosphorylation	HFDTLRVTKPEPAAL CCCEEEECCCCCCCC	34.15	-
967	Methylation	EAKKEAQKEKEIDEQ HHHHHHHHHHHCCHH	77.22	-
969	Methylation	KKEAQKEKEIDEQEA HHHHHHHHHCCHHHH	67.99	-
969	Ubiquitination	KKEAQKEKEIDEQEA HHHHHHHHHCCHHHH	67.99	-
984	Phosphorylation	NASTFHRSRTPLDKD HHHHHHHCCCCCCHH	31.75	26434776
986	Phosphorylation	STFHRSRTPLDKDLI HHHHHCCCCCCHHHC	29.47	23927012
990	Ubiquitination	RSRTPLDKDLINTGI HCCCCCCHHHCCCCC	63.22	21890473
1021	Phosphorylation	QLLRNIASQTVARLK HHHHHHHHHHHHHHH	23.69	-
1023	Phosphorylation	LRNIASQTVARLKDV HHHHHHHHHHHHHHH	17.40	-
1035	Phosphorylation	KDVARRISSCLDFEQ HHHHHHHHHHHCHHH	17.12	28555341
1087	Phosphorylation	PELMGVGSLLKKYTA HHHHCHHHHHHHHHH	28.29	24719451
1220	Ubiquitination	ADLENHNKDGGFWTV HHHCCCCCCCCEEEE	50.64	-
1231	Ubiquitination	FWTVIDGKVYDIKDF EEEEECCEEEECCCC	33.60	-
1365	Phosphorylation	EKDEDHCSSPGGTPA CCCCCCCCCCCCCHH	35.83	25849741
1366	Phosphorylation	KDEDHCSSPGGTPAS CCCCCCCCCCCCHHH	32.72	29255136
1370	Phosphorylation	HCSSPGGTPASKSRL CCCCCCCCHHHHHHH	22.92	29255136
1373	Phosphorylation	SPGGTPASKSRLCSH CCCCCHHHHHHHHHC	32.16	27251275
1374	Ubiquitination	PGGTPASKSRLCSHR CCCCHHHHHHHHHCH	41.52	-
1469	Ubiquitination	ALGIEQVKHRTLPKS CCCHHHHCCCCCCHH	27.36	-
1472	Phosphorylation	IEQVKHRTLPKSVVD HHHHCCCCCCHHHHH	47.32	-
1488	Ubiquitination	CRVVYQAKCSLIKTH HHHHHHHHCCHHHHH	14.61	-
1490	Phosphorylation	VVYQAKCSLIKTHQE HHHHHHCCHHHHHHH	32.21	24719451
1493	Ubiquitination	QAKCSLIKTHQEQGR HHHCCHHHHHHHCCC	45.29	-
1503	Ubiquitination	QEQGRSYKEVCAPVI HHCCCCHHHHHHHHH	44.94	-
1538	Phosphorylation	MSKFKLLSSLPRWRR HHHHHHHHCCHHHHH	40.02	23927012
1539	Phosphorylation	SKFKLLSSLPRWRRI HHHHHHHCCHHHHHH	42.22	28355574
1565	Phosphorylation	RVPKKPESTDDEEKI CCCCCCCCCCCHHHC	45.74	25002506
1566	Phosphorylation	VPKKPESTDDEEKIG CCCCCCCCCCHHHCC	45.89	25002506
1577	Phosphorylation	EKIGNEESDLEEACI HHCCCCCCCHHHHCC	41.12	29255136
1588	Phosphorylation	EACILPHSPINVDKR HHCCCCCCCCCCCCC	26.07	25159151
1594	Ubiquitination	HSPINVDKRPIAIKS CCCCCCCCCCCCCCC	56.65	-
1600	Ubiquitination	DKRPIAIKSPKDKWQ CCCCCCCCCCCCCCC	52.24	-
1601	Phosphorylation	KRPIAIKSPKDKWQP CCCCCCCCCCCCCCC	30.94	27794612
1605	Ubiquitination	AIKSPKDKWQPLLST CCCCCCCCCCCHHHH	54.58	-
1611	Phosphorylation	DKWQPLLSTVTGVHK CCCCCHHHHHCCHHH	28.63	23312004
1612	Phosphorylation	KWQPLLSTVTGVHKY CCCCHHHHHCCHHHH	23.27	23312004
1614	Phosphorylation	QPLLSTVTGVHKYKW CCHHHHHCCHHHHHH	33.31	23312004
1633	Phosphorylation	VQGLYPQSPLLSTIA HCCCCCCCHHHHHHH	17.01	-
1645	Ubiquitination	TIAEFALKEEPVDVE HHHHHHHCCCCCCHH	57.51	-
1660	Ubiquitination	KMRKCLLKQLERAEV HHHHHHHHHHHHHCH	39.63	-
1677	Ubiquitination	EGIDTILKLASKNFL HCHHHHHHHHHCCCC	37.85	-
1791	Phosphorylation	RFLLVMLSMLTLQHG HHHHHHHHHHHHHCC	8.14	-
1814	Phosphorylation	NSGMLALTQTALRLI HHHHHHHHHHHHHHH	20.47	-
1824	Phosphorylation	ALRLIGPSCDNVEED HHHHHCCCCCCHHHH	28.96	22468782
1835	Phosphorylation	VEEDMNASAQGASAT HHHHHCHHHCCCCCE	19.00	21712546
1840	Phosphorylation	NASAQGASATVLEET CHHHCCCCCEEHHHH	31.15	22468782
1842	Phosphorylation	SAQGASATVLEETRK HHCCCCCEEHHHHHC	24.11	22468782
1847	Phosphorylation	SATVLEETRKETAPV CCEEHHHHHCCCCCE	37.35	22468782
1851	O-linked_Glycosylation	LEETRKETAPVQLPV HHHHHCCCCCEECCC	39.02	30379171
1938	Phosphorylation	LPAAAQPSAEDSDTE CCCCCCCCCCCCCCC	32.01	30278072
1942	Phosphorylation	AQPSAEDSDTEDDSE CCCCCCCCCCCCHHH	37.63	25159151
1944	Phosphorylation	PSAEDSDTEDDSEAE CCCCCCCCCCHHHHH	45.31	30278072
1948	Phosphorylation	DSDTEDDSEAEQTER CCCCCCHHHHHHHHH	51.53	23927012
1953	Phosphorylation	DDSEAEQTERNIHPT CHHHHHHHHHHCCCC	28.55	30108239
1992	Phosphorylation	MQSEATKTLCGLLRM HCCHHHHHHHHHHHH	34.41	30301811
2003	Phosphorylation	LLRMLVESGTTDKTS HHHHHHHCCCCCCCC	33.68	29978859
2005	Phosphorylation	RMLVESGTTDKTSSP HHHHHCCCCCCCCCC	40.89	29214152
2006	Phosphorylation	MLVESGTTDKTSSPN HHHHCCCCCCCCCCC	38.74	29978859
2008	Ubiquitination	VESGTTDKTSSPNRL HHCCCCCCCCCCCCE	48.49	-
2009	Phosphorylation	ESGTTDKTSSPNRLV HCCCCCCCCCCCCEE	36.93	29978859
2010	Phosphorylation	SGTTDKTSSPNRLVY CCCCCCCCCCCCEEE	49.92	29978859
2011	Phosphorylation	GTTDKTSSPNRLVYR CCCCCCCCCCCEEEH	31.27	29978859
2063	Phosphorylation	VEGHAPFTATSLQRQ HHCCCCCCHHHHHHH	28.15	20860994
2065	Phosphorylation	GHAPFTATSLQRQIL CCCCCCHHHHHHHHH	27.23	20860994
2066	Phosphorylation	HAPFTATSLQRQILA CCCCCHHHHHHHHHH	21.75	27251275
2152	Phosphorylation	EVVALLRTLHSLTQW HHHHHHHHHHHHHHH	28.88	26126808
2155	Phosphorylation	ALLRTLHSLTQWNGL HHHHHHHHHHHHHHH	35.90	26126808
2157	Phosphorylation	LRTLHSLTQWNGLIN HHHHHHHHHHHHHHH	34.26	26126808
2302	Phosphorylation	EKHKIKKSTKQAFAG HHHHCCHHHHHHHCC	35.52	26670566
2303	Phosphorylation	KHKIKKSTKQAFAGQ HHHCCHHHHHHHCCC	35.73	26670566
2304	Ubiquitination	HKIKKSTKQAFAGQV HHCCHHHHHHHCCCC	46.88	-
2338	Ubiquitination	ALLSHQDKLRQILSQ HHHHCHHHHHHHHCC	38.71	-
2454	Phosphorylation	RVKRRKQSPVPALPI HCCCCCCCCCCCHHH	30.79	29255136
2657	Ubiquitination	SVTTPKYKWGSVTHQ EEECCCCCCCCCCCC	51.73	21890473
2662	Phosphorylation	KYKWGSVTHQSVGVV CCCCCCCCCCCCHHE	18.85	-
2772	Phosphorylation	KQLKRCHSSQPGMLL CCHHCCCCCCCCCHH	34.00	28450419
2773	Phosphorylation	QLKRCHSSQPGMLLD CHHCCCCCCCCCHHH	19.41	27251275
2788	Phosphorylation	SWSRMVKSLNVSSSV HHHHHHHHCCCCCCC	17.48	-
2817	Ubiquitination	QSSGSQGKHWIRLEI CCCCCCCCCEEEEEE	28.29	-
2893	Ubiquitination	RYIEIAIKQCRSSGI HHHHHHHHHHHHCCC	34.03	-
2928	Phosphorylation	AAVPFLASDNEEEED CCCCEECCCCHHHCC	43.02	29255136
2940	Phosphorylation	EEDEKGNSGSLIRKK HCCCCCCCCHHHHHH	38.13	22617229
2942	Phosphorylation	DEKGNSGSLIRKKAA CCCCCCCHHHHHHHC	22.05	26029660
2947	Ubiquitination	SGSLIRKKAAGLESA CCHHHHHHHCCCCCC	33.35	-
2953	Phosphorylation	KKAAGLESAATIRTK HHHCCCCCCCHHEEE	28.39	20860994
2956	Phosphorylation	AGLESAATIRTKVFV CCCCCCCHHEEEEEE	15.65	20860994
2969	Ubiquitination	FVWGLNDKDQLGGLK EEEECCCHHHCCCCC	46.42	-
2976	Ubiquitination	KDQLGGLKGSKIKVP HHHCCCCCCCCCCCC	65.50	-
2978	Phosphorylation	QLGGLKGSKIKVPSF HCCCCCCCCCCCCCH	29.62	20860994
2979	Ubiquitination	LGGLKGSKIKVPSFS CCCCCCCCCCCCCHH	56.04	-
3054	Phosphorylation	VKKVAVHSGGRHATA EEEEEECCCCCCEEE	36.02	23532336
3060	Phosphorylation	HSGGRHATALTVDGK CCCCCCEEEEEECCE	18.97	23532336
3063	Phosphorylation	GRHATALTVDGKVFS CCCEEEEEECCEEEE	17.68	21406692
3067	Ubiquitination	TALTVDGKVFSWGEG EEEEECCEEEECCCC	35.33	-
3078	Ubiquitination	WGEGDDGKLGHFSRM CCCCCCCCCCCHHCC	59.29	-
3097	Ubiquitination	PRLIEALKTKRIRDI HHHHHHHCCCCCCCC	60.08	-
3141	Ubiquitination	GDNTTQLKPKMVKVL CCCCCCCCHHHHHHH	32.54	-
3146	Ubiquitination	QLKPKMVKVLLGHRV CCCHHHHHHHHCCCE	24.54	-
3241	Phosphorylation	YFRLGHGSDVHVRKP CEEECCCCCCCCCCC	30.68	21406692
3247	Malonylation	GSDVHVRKPQVVEGL CCCCCCCCCHHHCCC	38.42	32601280
3247	Ubiquitination	GSDVHVRKPQVVEGL CCCCCCCCCHHHCCC	38.42	-
3299	Ubiquitination	GTTTVNRKPTLVQGL CCCCCCCCCCCCCCC	36.83	-
3366	Ubiquitination	DSSAASNKISGASNS CCHHHHCCCCCCCCC	35.44	-
3374	Ubiquitination	ISGASNSKPNRPSLA CCCCCCCCCCCCCHH	51.03	-
3382	Ubiquitination	PNRPSLAKILLSLDG CCCCCHHHHHHHCCC	38.90	-
3386	Phosphorylation	SLAKILLSLDGNLAK CHHHHHHHCCCCHHH	22.44	-
3462	Phosphorylation	VDIEDRLSPNPWQEK EECHHCCCCCCHHHH	24.43	30266825
3469	Ubiquitination	SPNPWQEKREIVSSE CCCCHHHHHCCCCCC	39.98	-
3474	Phosphorylation	QEKREIVSSEDAVTP HHHHCCCCCCCCCCC	33.40	29255136
3475	O-linked_Glycosylation	EKREIVSSEDAVTPS HHHCCCCCCCCCCCC	28.71	30379171
3475	Phosphorylation	EKREIVSSEDAVTPS HHHCCCCCCCCCCCC	28.71	29255136
3480	Phosphorylation	VSSEDAVTPSAVTPS CCCCCCCCCCCCCCC	17.16	26657352
3482	Phosphorylation	SEDAVTPSAVTPSAP CCCCCCCCCCCCCCC	26.46	29255136
3485	Phosphorylation	AVTPSAVTPSAPSAS CCCCCCCCCCCCCCC	15.96	29255136
3487	O-linked_Glycosylation	TPSAVTPSAPSASAR CCCCCCCCCCCCCCC	43.37	30379171
3487	Phosphorylation	TPSAVTPSAPSASAR CCCCCCCCCCCCCCC	43.37	29255136
3490	Phosphorylation	AVTPSAPSASARPFI CCCCCCCCCCCCCCC	34.27	29255136
3492	Phosphorylation	TPSAPSASARPFIPV CCCCCCCCCCCCCCC	29.19	29255136
3554	Ubiquitination	RVVVDLLKLSVCSRA HHHHHHHHHHHHCCC	46.11	-
3647	Phosphorylation	VEFDRQCSTERRHDP EEEECCCCCCCCCCC	25.60	-
3666	Phosphorylation	DGVNRIVSVRSGREW CCCCEEEEECCCCCC	14.94	24719451
3674	Phosphorylation	VRSGREWSDWSSELR ECCCCCCCCCCCCEE	25.17	-
3677	Phosphorylation	GREWSDWSSELRIPG CCCCCCCCCCEECCC	20.94	-
3678	Phosphorylation	REWSDWSSELRIPGD CCCCCCCCCEECCCC	36.07	-
3688	Ubiquitination	RIPGDELKWKFISDG ECCCCCCEEEEECCC	46.41	-
3690	Ubiquitination	PGDELKWKFISDGSV CCCCCEEEEECCCCC	31.09	21890473
3705	Phosphorylation	NGWGWRFTVYPIMPA CCCEEEEEEEECCCC	15.57	21406692
3707	Phosphorylation	WGWRFTVYPIMPAAG CEEEEEEEECCCCCC	5.51	21406692
3716	Ubiquitination	IMPAAGPKELLSDRC CCCCCCCHHHCCCCE	61.14	-
3756	Phosphorylation	IVPRLAASLAACAQL HHHHHHHHHHHHHHH	16.97	25278378
3764	Phosphorylation	LAACAQLSALAASHR HHHHHHHHHHHHHHH	14.79	20873877
3769	Phosphorylation	QLSALAASHRMWALQ HHHHHHHHHHHHHHH	13.15	20873877
3780	Ubiquitination	WALQRLRKLLTTEFG HHHHHHHHHHHHHHH	53.06	21890473
3807	Phosphorylation	DGETRALSFTGSALA CCCCEEEEEHHHHHH	21.56	21406692
3809	Phosphorylation	ETRALSFTGSALAAL CCEEEEEHHHHHHHH	27.18	21406692
3811	Phosphorylation	RALSFTGSALAALVK EEEEEHHHHHHHHHC	19.63	21406692
3839	Ubiquitination	DPIVRGGKQLLHSPF CCCCCCCHHHHCCHH	40.37	21890473
4133	Ubiquitination	SDSEDQLKPKLVEAL CCCCHHHCHHHHHHH	34.18	-
4182	O-linked_Glycosylation	GKLGRGGSDGCKVPM CCCCCCCCCCCCCCE	33.38	30379171
4193	Phosphorylation	KVPMKIDSLTGLGVV CCCEEECCCCCCEEE	31.16	29523821
4195	Phosphorylation	PMKIDSLTGLGVVKV CEEECCCCCCEEEEE	34.02	29523821
4213	Phosphorylation	SQFSVALTKSGAVYT CEEEEEEECCCCEEE	17.27	28302921
4249	Acetylation	QVQGLQGKKVIAIAT HCCCCCCCEEEEEEC	30.79	30589141
4396	Ubiquitination	GILISQGKEAAFRKV HHHHHCCHHHHHHHH	36.22	-
4402	Ubiquitination	GKEAAFRKVVQATMV CHHHHHHHHHHHHHC	40.06	-
4430	Phosphorylation	IQVKRSRSKGGLAGP EEEECCCCCCCCCCC	36.58	30624053
4431	Ubiquitination	QVKRSRSKGGLAGPD EEECCCCCCCCCCCC	56.75	-
4441	Ubiquitination	LAGPDGTKSVFGQMC CCCCCCCHHHHHHHH	50.59	-
4458	Phosphorylation	MSSFGPDSLLLPHRV HHHCCCCCCCCCCCE	24.85	22964224
4518	Phosphorylation	SGANRDCYLLSPAAR CCCCCCCEEECHHHC	18.24	27174698
4521	Phosphorylation	NRDCYLLSPAARAPV CCCCEEECHHHCCCC	15.19	27174698
4566	Phosphorylation	WKQLAGMSLTIADLS HHHHHCCCEEEHHHH	22.80	-
4568	Phosphorylation	QLAGMSLTIADLSEV HHHCCCEEEHHHHHC	13.55	-
4585	Phosphorylation	DFIPGLMYIRDNEAT CCCCCCEEEECCCCC	9.61	-
4687	Phosphorylation	IPLHLLKSVATYKGI CCHHHHHHHHHHCCC	19.56	20068231
4690	Phosphorylation	HLLKSVATYKGIEPS HHHHHHHHHCCCCCC	24.50	20068231
4691	Phosphorylation	LLKSVATYKGIEPSA HHHHHHHHCCCCCCH	9.47	20068231
4697	Phosphorylation	TYKGIEPSASLIQWF HHCCCCCCHHHHHHH	20.07	20068231
4699	Phosphorylation	KGIEPSASLIQWFWE CCCCCCHHHHHHHHH	30.28	20068231
4710	Phosphorylation	WFWEVMESFSNTERS HHHHHHHHCCCCCHH	18.84	20068231
4712	Phosphorylation	WEVMESFSNTERSLF HHHHHHCCCCCHHHH	52.72	22210691
4714	Phosphorylation	VMESFSNTERSLFLR HHHHCCCCCHHHHHH	31.42	22210691
4774	Ubiquitination	KLPRYSCKQVLEEKL HCCCCCHHHHHHHHH	37.18	-
4780	Ubiquitination	CKQVLEEKLKYAIHF HHHHHHHHHHHHHHH	40.69	-
4790	Phosphorylation	YAIHFCKSIDTDDYA HHHHHHHCCCCCCCE	27.20	20860994
4796	Phosphorylation	KSIDTDDYARIALTG HCCCCCCCEEEEECC	10.69	22817900
4810	Phosphorylation	GEPAADDSSDDSDNE CCCCCCCCCCCCCCC	35.89	18669648
4811	Phosphorylation	EPAADDSSDDSDNED CCCCCCCCCCCCCCC	53.05	18669648
4814	Phosphorylation	ADDSSDDSDNEDVDS CCCCCCCCCCCCHHH	47.53	18669648
4827	Phosphorylation	DSFASDSTQDYLTGH HHHHCHHHHHHHCCC	30.37	22508508

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of HERC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
4827	T	Phosphorylation		20023648
Phosphorylation at Thr-4827 is required for interaction with RNF8.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of HERC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	20631078
RNF8_HUMAN	RNF8	physical	20023648
NEUL4_HUMAN	NEURL4	physical	22261722
SSA27_HUMAN	SSSCA1	physical	22261722
ECI2_HUMAN	ECI2	physical	22261722
RFA3_HUMAN	RPA3	physical	22261722
RFA1_HUMAN	RPA1	physical	22261722
CE170_HUMAN	CEP170	physical	22261722
SRGP2_HUMAN	SRGAP2	physical	22261722
TBK1_HUMAN	TBK1	physical	22261722
TANK_HUMAN	TANK	physical	22261722
S23IP_HUMAN	SEC23IP	physical	22261722
KTN1_HUMAN	KTN1	physical	22261722
HERC2_HUMAN	HERC2	physical	22496338
UB2D3_HUMAN	UBE2D3	physical	20631078
XPA_HUMAN	XPA	physical	23178497
P53_HUMAN	TP53	physical	24722987
FBXL5_HUMAN	FBXL5	physical	24778179
UBP16_HUMAN	USP16	physical	25305019
BIRC6_HUMAN	BIRC6	physical	26186194
GET4_HUMAN	GET4	physical	26186194
MINY1_HUMAN	FAM63A	physical	26186194
RIPK1_HUMAN	RIPK1	physical	26186194
RN115_HUMAN	RNF115	physical	26186194
DNJB5_HUMAN	DNAJB5	physical	26186194
HXD13_HUMAN	HOXD13	physical	26186194
GRDN_HUMAN	CCDC88A	physical	26186194
HERC3_HUMAN	HERC3	physical	26186194
HOOK1_HUMAN	HOOK1	physical	26186194
RABE1_HUMAN	RABEP1	physical	26186194
FA83H_HUMAN	FAM83H	physical	26186194
INP4A_HUMAN	INPP4A	physical	26344197
MUS81_HUMAN	MUS81	physical	25476789
CCD22_HUMAN	CCDC22	physical	25476789
AGAP3_HUMAN	AGAP3	physical	25476789
ARHG5_HUMAN	ARHGEF5	physical	25476789
EME1_HUMAN	EME1	physical	25476789
HERC1_HUMAN	HERC1	physical	25476789
KI20A_HUMAN	KIF20A	physical	25476789
HPS3_HUMAN	HPS3	physical	25476789
HPS5_HUMAN	HPS5	physical	25476789
TBA1C_HUMAN	TUBA1C	physical	25476789
KMT2D_HUMAN	KMT2D	physical	25476789
RAB34_HUMAN	RAB34	physical	25476789
NEUL4_HUMAN	NEURL4	physical	25476789
ZDH17_HUMAN	ZDHHC17	physical	25476789
EPHA7_HUMAN	EPHA7	physical	25476789
ZBTB5_HUMAN	ZBTB5	physical	25476789
NU153_HUMAN	NUP153	physical	25476789
TF3C2_HUMAN	GTF3C2	physical	25476789
MLF2_HUMAN	MLF2	physical	25476789
ARNT_HUMAN	ARNT	physical	25476789
MCE1_HUMAN	RNGTT	physical	25476789
CC186_HUMAN	CCDC186	physical	25476789
TRM2A_HUMAN	TRMT2A	physical	25476789
FDFT_HUMAN	FDFT1	physical	25476789
ASAH1_HUMAN	ASAH1	physical	25476789
MAVS_HUMAN	MAVS	physical	25476789
CYTS_HUMAN	CST4	physical	25476789
SPTC2_HUMAN	SPTLC2	physical	25476789
ZG16B_HUMAN	ZG16B	physical	25476789
FBX50_HUMAN	NCCRP1	physical	25476789
1A02_HUMAN	HLA-A	physical	25476789
1A03_HUMAN	HLA-A	physical	25476789
1A01_HUMAN	HLA-A	physical	25476789
1A26_HUMAN	HLA-A	physical	25476789
HM13_HUMAN	HM13	physical	25476789
VDAC2_HUMAN	VDAC2	physical	25476789
K2C80_HUMAN	KRT80	physical	25476789
CYTA_HUMAN	CSTA	physical	25476789
BLMH_HUMAN	BLMH	physical	25476789
PSB4_HUMAN	PSMB4	physical	25476789
PSMD1_HUMAN	PSMD1	physical	25476789
PSD11_HUMAN	PSMD11	physical	25476789
PELP1_HUMAN	PELP1	physical	25476789
TEX10_HUMAN	TEX10	physical	25476789
ITPR2_HUMAN	ITPR2	physical	25476789
PTN1_HUMAN	PTPN1	physical	25476789
GNA13_HUMAN	GNA13	physical	25476789
FND3A_HUMAN	FNDC3A	physical	25476789
EPCAM_HUMAN	EPCAM	physical	25476789
NCOA4_HUMAN	NCOA4	physical	25476789
LACTB_HUMAN	LACTB	physical	25476789
NEK11_HUMAN	NEK11	physical	25476789
HLAE_HUMAN	HLA-E	physical	25476789
LMNB2_HUMAN	LMNB2	physical	25476789
FRIH_HUMAN	FTH1	physical	25476789
MLEC_HUMAN	MLEC	physical	25476789
LMNA_HUMAN	LMNA	physical	25476789
BIRC6_HUMAN	BIRC6	physical	25476789
RMP_HUMAN	URI1	physical	25476789
PPM1B_HUMAN	PPM1B	physical	25476789
COPB2_HUMAN	COPB2	physical	25476789
OBSL1_HUMAN	OBSL1	physical	25476789
COPG2_HUMAN	COPG2	physical	25476789
COPG1_HUMAN	COPG1	physical	25476789
COPA_HUMAN	COPA	physical	25476789
BICD1_HUMAN	BICD1	physical	25476789
BICD2_HUMAN	BICD2	physical	25476789
ZFYV9_HUMAN	ZFYVE9	physical	25476789
CE170_HUMAN	CEP170	physical	25476789
SNAPN_HUMAN	SNAPIN	physical	25476789
UBE3A_HUMAN	UBE3A	physical	25476789
ZNT9_HUMAN	SLC30A9	physical	25476789
PCM1_HUMAN	PCM1	physical	25476789
FHOD3_HUMAN	FHOD3	physical	25476789
AKAP9_HUMAN	AKAP9	physical	25476789
NIN_HUMAN	NIN	physical	25476789
NUDC2_HUMAN	NUDCD2	physical	25476789
S27A4_HUMAN	SLC27A4	physical	25476789
ASPM_HUMAN	ASPM	physical	25476789
PEX1_HUMAN	PEX1	physical	25476789
UBP20_HUMAN	USP20	physical	25476789
ETAA1_HUMAN	ETAA1	physical	25476789
PR14L_HUMAN	PRR14L	physical	25476789
RIC8A_HUMAN	RIC8A	physical	25476789
PHKG2_HUMAN	PHKG2	physical	25476789
SCO2_HUMAN	SCO2	physical	25476789
WDR62_HUMAN	WDR62	physical	25476789
GNAS3_HUMAN	GNAS	physical	25476789
GNAS2_HUMAN	GNAS	physical	25476789
ALEX_HUMAN	GNAS	physical	25476789
GNAS1_HUMAN	GNAS	physical	25476789
KPBB_HUMAN	PHKB	physical	25476789
KPB2_HUMAN	PHKA2	physical	25476789
ENPP1_HUMAN	ENPP1	physical	25476789
EIF3H_HUMAN	EIF3H	physical	25476789
MIO_HUMAN	MIOS	physical	25476789
EIF3A_HUMAN	EIF3A	physical	25476789
OCRL_HUMAN	OCRL	physical	25476789
MTMR3_HUMAN	MTMR3	physical	25476789
EIF3E_HUMAN	EIF3E	physical	25476789
KPB1_HUMAN	PHKA1	physical	25476789
WDR59_HUMAN	WDR59	physical	25476789
EIF3B_HUMAN	EIF3B	physical	25476789
EIF3L_HUMAN	EIF3L	physical	25476789
EIF3M_HUMAN	EIF3M	physical	25476789
IF4G1_HUMAN	EIF4G1	physical	25476789
EIF3G_HUMAN	EIF3G	physical	25476789
EIF3C_HUMAN	EIF3C	physical	25476789
EIF3K_HUMAN	EIF3K	physical	25476789
EIF3D_HUMAN	EIF3D	physical	25476789
CTNA1_HUMAN	CTNNA1	physical	25476789
CTNB1_HUMAN	CTNNB1	physical	25476789
WDR24_HUMAN	WDR24	physical	25476789
EIF3I_HUMAN	EIF3I	physical	25476789
GCC2_HUMAN	GCC2	physical	25476789
PLSL_HUMAN	LCP1	physical	25476789
SELO_HUMAN	SELO	physical	25476789
CYTSA_HUMAN	SPECC1L	physical	25476789
SNX6_HUMAN	SNX6	physical	25476789
ARAF_HUMAN	ARAF	physical	25476789
TBB3_HUMAN	TUBB3	physical	25476789
RAF1_HUMAN	RAF1	physical	25476789
ABR_HUMAN	ABR	physical	25476789
RER1_HUMAN	RER1	physical	25476789
TXLNG_HUMAN	TXLNG	physical	25476789
CBX2_HUMAN	CBX2	physical	25476789
SENP1_HUMAN	SENP1	physical	25476789
ATP4A_HUMAN	ATP4A	physical	25476789
EXD2_HUMAN	EXD2	physical	25476789
ADIP_HUMAN	SSX2IP	physical	25476789
MPIP3_HUMAN	CDC25C	physical	25476789
MYO9B_HUMAN	MYO9B	physical	25476789
CX057_HUMAN	CXorf57	physical	25476789
SOGA1_HUMAN	SOGA1	physical	25476789
FLII_HUMAN	FLII	physical	25476789
FAKD5_HUMAN	FASTKD5	physical	25476789
CPT1A_HUMAN	CPT1A	physical	25476789
AURKB_HUMAN	AURKB	physical	25476789
WDR92_HUMAN	WDR92	physical	25476789
COPZ1_HUMAN	COPZ1	physical	25476789
FRIL_HUMAN	FTL	physical	25476789
COPE_HUMAN	COPE	physical	25476789
KAP3_HUMAN	PRKAR2B	physical	25476789
RAB5A_HUMAN	RAB5A	physical	26355680
RAB5B_HUMAN	RAB5B	physical	26355680
NCOA4_HUMAN	NCOA4	physical	26436293
HERC2_HUMAN	HERC2	physical	26949039
UBP20_HUMAN	USP20	physical	25355518
CLSPN_HUMAN	CLSPN	physical	25326330
UBP20_HUMAN	USP20	physical	25326330
SIR1_HUMAN	SIRT1	physical	27259994
STK11_HUMAN	STK11	physical	27259994
UB2D1_HUMAN	UBE2D1	physical	27259994
UBE2N_HUMAN	UBE2N	physical	27259994
P53_HUMAN	TP53	physical	27259994
RABE1_HUMAN	RABEP1	physical	28514442
DNJB5_HUMAN	DNAJB5	physical	28514442
LG3BP_HUMAN	LGALS3BP	physical	28514442
RN115_HUMAN	RNF115	physical	28514442
HOOK1_HUMAN	HOOK1	physical	28514442
GRDN_HUMAN	CCDC88A	physical	28514442
BIRC6_HUMAN	BIRC6	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615516	Mental retardation, autosomal recessive 38 (MRT38)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of HERC2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2454, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1942 AND THR-1944, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2928; SER-4810; SER-4811AND SER-4814, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2928, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1577; SER-1588 ANDSER-2928, AND MASS SPECTROMETRY.	17081983 [Abstract]
"HERC2 coordinates ubiquitin-dependent assembly of DNA repair factorson damaged chromosomes."; Bekker-Jensen S., Rendtlew Danielsen J., Fugger K., Gromova I.,Nerstedt A., Lukas C., Bartek J., Lukas J., Mailand N.; Nat. Cell Biol. 12:80-86(2010). Cited for: FUNCTION, INTERACTION WITH RNF8, PHOSPHORYLATION AT THR-4827,MUTAGENESIS OF THR-4827, AND SUBCELLULAR LOCATION.	20023648 [Abstract]

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