EPHA7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EPHA7_HUMAN
• UniProt AC: Q15375
• Protein Name: Ephrin type-A receptor 7
• Gene Name: EPHA7
• Organism: Homo sapiens (Human).
• Sequence Length: 998
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein .
• Protein Description: Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7..
• Protein Sequence: MVFQTRYPSWIILCYIWLLRFAHTGEAQAAKEVLLLDSKAQQTELEWISSPPNGWEEISGLDENYTPIRTYQVCQVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKETFNLYYYETDYDTGRNIRENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKCWSIIENLAIFPDTVTGSEFSSLVEVRGTCVSSAEEEAENAPRMHCSAEGEWLVPIGKCICKAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPTHSFSDKEGSSRCECEDGYYRAPSDPPYVACTRPPSAPQNLIFNINQTTVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAHANYTFEVEAVNGVSDLSRSQRLFAAVSITTGQAAPSQVSGVMKERVLQRSVELSWQEPEHPNGVITEYEIKYYEKDQRERTYSTVKTKSTSASINNLKPGTVYVFQIRAFTAAGYGNYSPRLDVATLEEATGKMFEATAVSSEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEELYFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDASCIKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQIVGILDKMIRNPNSLKTPLGTCSRPISPLLDQNTPDFTTFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIEDVMSLGITLVGHQKKIMSSIQTMRAQMLHLHGTGIQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
87	Phosphorylation	NQNNWLRTNWISKGN CCCCEEEEEEEECCC	32.50	-
91	Phosphorylation	WLRTNWISKGNAQRI EEEEEEEECCCCEEE	26.56	-
105	Phosphorylation	IFVELKFTLRDCNSL EEEEEEEEHHHCCCC	21.21	24719451
111	Phosphorylation	FTLRDCNSLPGVLGT EEHHHCCCCCCCEEC	42.12	22210691
118	Phosphorylation	SLPGVLGTCKETFNL CCCCCEECCCCEEEE	19.08	22210691
122	Phosphorylation	VLGTCKETFNLYYYE CEECCCCEEEEEEEE	11.88	24043423
126	Phosphorylation	CKETFNLYYYETDYD CCCEEEEEEEECCCC	12.71	24043423
127	Phosphorylation	KETFNLYYYETDYDT CCEEEEEEEECCCCC	9.67	24043423
128	Phosphorylation	ETFNLYYYETDYDTG CEEEEEEEECCCCCC	9.97	24043423
130	Phosphorylation	FNLYYYETDYDTGRN EEEEEEECCCCCCCC	24.60	24043423
132	Phosphorylation	LYYYETDYDTGRNIR EEEEECCCCCCCCHH	23.87	24043423
134	Phosphorylation	YYETDYDTGRNIREN EEECCCCCCCCHHHC	31.63	24043423
201	Phosphorylation	ALVSVKVYYKKCWSI HHEEHHHHHHHHHHH	12.12	-
202	Phosphorylation	LVSVKVYYKKCWSII HEEHHHHHHHHHHHH	13.63	-
236	Phosphorylation	EVRGTCVSSAEEEAE EEECEECCCHHHHHH	26.44	29759185
237	Phosphorylation	VRGTCVSSAEEEAEN EECEECCCHHHHHHH	21.21	29759185
307	Phosphorylation	SFSDKEGSSRCECED CCCCCCCCCCEECCC	18.72	-
308	Phosphorylation	FSDKEGSSRCECEDG CCCCCCCCCEECCCC	52.38	-
343	N-linked_Glycosylation	QNLIFNINQTTVSLE CCEEEEECCCEEEEE	33.96	UniProtKB CARBOHYD
410	N-linked_Glycosylation	MDLLAHANYTFEVEA HHHHHHCCEEEEEEE	26.89	UniProtKB CARBOHYD
437	O-linked_Glycosylation	LFAAVSITTGQAAPS HEEEEEEECCCCCHH	19.84	29351928
444	O-linked_Glycosylation	TTGQAAPSQVSGVMK ECCCCCHHHCCHHHH	38.19	29351928
501	Phosphorylation	KTKSTSASINNLKPG EECCCCCEECCCCCC	26.14	-
511	Ubiquitination	NLKPGTVYVFQIRAF CCCCCEEEEEEEEEE	8.72	32015554
525	Ubiquitination	FTAAGYGNYSPRLDV EECCCCCCCCCCCCE	26.14	32015554
539	Phosphorylation	VATLEEATGKMFEAT EEEHHHHCCCEEEEE	40.38	20071362
582	Ubiquitination	GFIIGRRHCGYSKAD HHHHCCCCCCCCCCC	14.16	32015554
587	Ubiquitination	RRHCGYSKADQEGDE CCCCCCCCCCCCCCC	47.72	32015554
596	Ubiquitination	DQEGDEELYFHFKFP CCCCCCEEEEEEECC	5.35	21890473
596 (in isoform 2)	Ubiquitination	-	5.35	21890473
597	Phosphorylation	QEGDEELYFHFKFPG CCCCCEEEEEEECCC	9.78	27259358
601	Ubiquitination	EELYFHFKFPGTKTY CEEEEEEECCCCCCE	41.92	21890473
601	Ubiquitination	EELYFHFKFPGTKTY CEEEEEEECCCCCCE	41.92	22817900
601 (in isoform 1)	Ubiquitination	-	41.92	21890473
601 (in isoform 2)	Ubiquitination	-	41.92	-
606	Ubiquitination	HFKFPGTKTYIDPET EEECCCCCCEECHHH	45.29	22817900
607	Phosphorylation	FKFPGTKTYIDPETY EECCCCCCEECHHHC	26.08	29978859
608	Phosphorylation	KFPGTKTYIDPETYE ECCCCCCEECHHHCC	12.60	25884760
613	Phosphorylation	KTYIDPETYEDPNRA CCEECHHHCCCCCHH	37.28	-
614	Phosphorylation	TYIDPETYEDPNRAV CEECHHHCCCCCHHH	19.37	25884760
634	Ubiquitination	ELDASCIKIERVIGA HHCHHCEEEEEEECC	42.73	-
656	Ubiquitination	SGRLKLPGKRDVAVA CCCCCCCCCHHHEEE	48.33	23503661
657	Ubiquitination	GRLKLPGKRDVAVAI CCCCCCCCHHHEEEE	43.41	-
659	Ubiquitination	LKLPGKRDVAVAIKT CCCCCCHHHEEEEEE	35.89	25015289
660	Ubiquitination	KLPGKRDVAVAIKTL CCCCCHHHEEEEEEE	5.54	23503661
660 (in isoform 2)	Ubiquitination	-	5.54	-
661	Ubiquitination	LPGKRDVAVAIKTLK CCCCHHHEEEEEEEC	6.85	23503661
663	Ubiquitination	GKRDVAVAIKTLKVG CCHHHEEEEEEECCC	6.45	25015289
664	Ubiquitination	KRDVAVAIKTLKVGY CHHHEEEEEEECCCC	2.55	25015289
665	Ubiquitination	RDVAVAIKTLKVGYT HHHEEEEEEECCCCC	37.76	25015289
666	Phosphorylation	DVAVAIKTLKVGYTE HHEEEEEEECCCCCH	26.21	22461510
668	Ubiquitination	AVAIKTLKVGYTEKQ EEEEEEECCCCCHHH	38.55	25015289
669	Ubiquitination	VAIKTLKVGYTEKQR EEEEEECCCCCHHHH	8.79	25015289
670	Ubiquitination	AIKTLKVGYTEKQRR EEEEECCCCCHHHHH	23.27	25015289
671	Phosphorylation	IKTLKVGYTEKQRRD EEEECCCCCHHHHHH	18.08	22461510
674	Ubiquitination	LKVGYTEKQRRDFLC ECCCCCHHHHHHCEE	41.11	25015289
731	Phosphorylation	RKHDGQFTVIQLVGM HHCCCCEEHHHHHHH	14.60	22210691
748	Phosphorylation	GIAAGMRYLADMGYV HHHHHHHHHHHCCCC	9.43	-
754	Phosphorylation	RYLADMGYVHRDLAA HHHHHCCCCCHHHHH	6.09	-
764	Ubiquitination	RDLAARNILVNSNLV HHHHHHCEEECCCEE	3.66	21987572
768	Phosphorylation	ARNILVNSNLVCKVS HHCEEECCCEEEEEC	24.86	-
768	Ubiquitination	ARNILVNSNLVCKVS HHCEEECCCEEEEEC	24.86	21987572
769	Ubiquitination	RNILVNSNLVCKVSD HCEEECCCEEEEECH	31.15	21987572
773	Ubiquitination	VNSNLVCKVSDFGLS ECCCEEEEECHHCCC	36.98	21987572
775	Phosphorylation	SNLVCKVSDFGLSRV CCEEEEECHHCCCEE	16.83	-
780	Phosphorylation	KVSDFGLSRVIEDDP EECHHCCCEEECCCC	25.53	22817900
788	Ubiquitination	RVIEDDPEAVYTTTG EEECCCCCCEEECCC	58.73	23503661
791	Phosphorylation	EDDPEAVYTTTGGKI CCCCCCEEECCCCCC	12.86	30175587
792	Phosphorylation	DDPEAVYTTTGGKIP CCCCCEEECCCCCCC	15.98	29978859
792	Ubiquitination	DDPEAVYTTTGGKIP CCCCCEEECCCCCCC	15.98	23503661
792 (in isoform 2)	Ubiquitination	-	15.98	-
793	Phosphorylation	DPEAVYTTTGGKIPV CCCCEEECCCCCCCC	13.03	29978859
793	Ubiquitination	DPEAVYTTTGGKIPV CCCCEEECCCCCCCC	13.03	23503661
794	Phosphorylation	PEAVYTTTGGKIPVR CCCEEECCCCCCCCE	35.82	29978859
797	Ubiquitination	VYTTTGGKIPVRWTA EEECCCCCCCCEEEC	45.22	23503661
810	Phosphorylation	TAPEAIQYRKFTSAS ECCHHHHCCCCCCHH	15.06	22461510
816	Ubiquitination	QYRKFTSASDVWSYG HCCCCCCHHHHHHHH	13.49	32015554
821	Phosphorylation	TSASDVWSYGIVMWE CCHHHHHHHHEEEEE	17.21	22210691
822	Phosphorylation	SASDVWSYGIVMWEV CHHHHHHHHEEEEEE	8.65	22210691
853	Phosphorylation	IKAIEEGYRLPAPMD HHHHHCCCCCCCCCC	16.56	22210691
883	Ubiquitination	ERAERPKFEQIVGIL HHHCCCCHHHHHHHH	10.40	21890473
887	Ubiquitination	RPKFEQIVGILDKMI CCCHHHHHHHHHHHC	3.79	21890473
887 (in isoform 2)	Ubiquitination	-	3.79	21890473
888	Ubiquitination	PKFEQIVGILDKMIR CCHHHHHHHHHHHCC	19.17	21890473
892	Ubiquitination	QIVGILDKMIRNPNS HHHHHHHHHCCCCCC	32.55	21890473
892	Ubiquitination	QIVGILDKMIRNPNS HHHHHHHHHCCCCCC	32.55	22817900
892 (in isoform 1)	Ubiquitination	-	32.55	21890473
912	Phosphorylation	GTCSRPISPLLDQNT CCCCCCCHHHHCCCC	16.51	22210691
919	Phosphorylation	SPLLDQNTPDFTTFC HHHHCCCCCCCCCCC	20.71	22210691
924	Phosphorylation	QNTPDFTTFCSVGEW CCCCCCCCCCCHHHH	23.72	22210691
927	Ubiquitination	PDFTTFCSVGEWLQA CCCCCCCCHHHHHHH	29.03	23503661
931	Ubiquitination	TFCSVGEWLQAIKME CCCCHHHHHHHHHHH	6.45	23503661
932	Ubiquitination	FCSVGEWLQAIKMER CCCHHHHHHHHHHHH	1.83	23503661
936	Ubiquitination	GEWLQAIKMERYKDN HHHHHHHHHHHCCCC	37.41	23503661
936 (in isoform 2)	Ubiquitination	-	37.41	-
937	Ubiquitination	EWLQAIKMERYKDNF HHHHHHHHHHCCCCC	2.64	23503661
940	Phosphorylation	QAIKMERYKDNFTAA HHHHHHHCCCCCCHH	14.91	-
941	Ubiquitination	AIKMERYKDNFTAAG HHHHHHCCCCCCHHC	53.03	23503661
949	Phosphorylation	DNFTAAGYNSLESVA CCCCHHCCCCHHHHH	9.24	26471730
951	Phosphorylation	FTAAGYNSLESVARM CCHHCCCCHHHHHCC	25.65	25849741
959	Phosphorylation	LESVARMTIEDVMSL HHHHHCCCHHHHHHC	18.70	22210691
966	Ubiquitination	TIEDVMSLGITLVGH CHHHHHHCCEEEEHH	2.88	23503661
967	Ubiquitination	IEDVMSLGITLVGHQ HHHHHHCCEEEEHHH	11.97	23503661
970	Ubiquitination	VMSLGITLVGHQKKI HHHCCEEEEHHHHHH	4.03	23503661
970 (in isoform 2)	Ubiquitination	-	4.03	-
971	Ubiquitination	MSLGITLVGHQKKIM HHCCEEEEHHHHHHH	4.88	23503661
972	Ubiquitination	SLGITLVGHQKKIMS HCCEEEEHHHHHHHH	22.18	23503661
975	Ubiquitination	ITLVGHQKKIMSSIQ EEEEHHHHHHHHHHH	38.30	23503661
976	Ubiquitination	TLVGHQKKIMSSIQT EEEHHHHHHHHHHHH	36.75	23503661
979	Phosphorylation	GHQKKIMSSIQTMRA HHHHHHHHHHHHHHH	27.97	24043423
980	Phosphorylation	HQKKIMSSIQTMRAQ HHHHHHHHHHHHHHH	11.01	24043423
983	Phosphorylation	KIMSSIQTMRAQMLH HHHHHHHHHHHHHHH	13.62	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EPHA7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EPHA7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EPHA7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MLP3A_HUMAN	MAP1LC3A	physical	21988832
GBB1_HUMAN	GNB1	physical	21988832
ZN267_HUMAN	ZNF267	physical	21988832
EPHAA_HUMAN	EPHA10	physical	28514442
EPHA3_HUMAN	EPHA3	physical	28514442
EFNA5_HUMAN	EFNA5	physical	28514442
BCAM_HUMAN	BCAM	physical	28514442
NID2_HUMAN	NID2	physical	28514442
SMOC1_HUMAN	SMOC1	physical	28514442
MICA_HUMAN	MICA	physical	28514442
RL23_HUMAN	RPL23	physical	28514442
EPHA4_HUMAN	EPHA4	physical	28514442
NPTX1_HUMAN	NPTX1	physical	28514442
TBA4A_HUMAN	TUBA4A	physical	28514442
GRP78_HUMAN	HSPA5	physical	28514442
BORA_HUMAN	BORA	physical	28514442
AGAP1_HUMAN	AGAP1	physical	28514442
EMC1_HUMAN	EMC1	physical	28514442
OAF_HUMAN	OAF	physical	28514442
SYIM_HUMAN	IARS2	physical	28514442
WNT5A_HUMAN	WNT5A	physical	28514442
PYC_HUMAN	PC	physical	28514442
DUS18_HUMAN	DUSP18	physical	28065597
DUS26_HUMAN	DUSP26	physical	28065597
STYX_HUMAN	STYX	physical	28065597
MTMRE_HUMAN	MTMR14	physical	28065597

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.