| UniProt ID | STYX_HUMAN | |
|---|---|---|
| UniProt AC | Q8WUJ0 | |
| Protein Name | Serine/threonine/tyrosine-interacting protein {ECO:0000305} | |
| Gene Name | STYX {ECO:0000312|HGNC:HGNC:11447} | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 223 | |
| Subcellular Localization | Nucleus . Cytoplasm, cytosol . Predominantly localizes to the nucleus. | |
| Protein Description | Catalytically inactive phosphatase. [PubMed: 23847209 Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2)] | |
| Protein Sequence | MEDVKLEFPSLPQCKEDAEEWTYPMRREMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMMSPLQIERSLSVHSGTTGSLKRTHEEEDDFGTMQVATAQNG | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 10 | Phosphorylation | DVKLEFPSLPQCKED CCCCCCCCCCCCCCC | 58.99 | 28555341 | |
| 46 | Ubiquitination | GPYSSAMKSKLPVLQ CCCHHHHHHCCCHHH | 44.12 | - | |
| 48 | Ubiquitination | YSSAMKSKLPVLQKH CHHHHHHCCCHHHHC | 51.82 | - | |
| 125 | Phosphorylation | VHGNAGISRSAAFVI EECCCCCCHHHHHHH | 21.18 | - | |
| 127 | Phosphorylation | GNAGISRSAAFVIAY CCCCCCHHHHHHHHH | 19.70 | 25219547 | |
| 134 | Phosphorylation | SAAFVIAYIMETFGM HHHHHHHHHHHHHCC | 6.95 | 25219547 | |
| 138 | Phosphorylation | VIAYIMETFGMKYRD HHHHHHHHHCCCHHH | 14.22 | 25219547 | |
| 179 | Phosphorylation | AIYLAKLTIQMMSPL HHHHHHHHHHHCCCC | 14.41 | 23186163 | |
| 184 | Phosphorylation | KLTIQMMSPLQIERS HHHHHHCCCCEEEEE | 19.67 | 22199227 | |
| 191 | Phosphorylation | SPLQIERSLSVHSGT CCCEEEEEEEECCCC | 16.53 | 28348404 | |
| 193 | Phosphorylation | LQIERSLSVHSGTTG CEEEEEEEECCCCCC | 21.02 | 23401153 | |
| 196 | Phosphorylation | ERSLSVHSGTTGSLK EEEEEECCCCCCCEE | 35.36 | 25159151 | |
| 198 | Phosphorylation | SLSVHSGTTGSLKRT EEEECCCCCCCEECC | 30.88 | 29507054 | |
| 199 | Phosphorylation | LSVHSGTTGSLKRTH EEECCCCCCCEECCC | 28.44 | 28450419 | |
| 201 | Phosphorylation | VHSGTTGSLKRTHEE ECCCCCCCEECCCCC | 28.73 | 25159151 | |
| 203 | Acetylation | SGTTGSLKRTHEEED CCCCCCEECCCCCCC | 57.88 | 25953088 | |
| 203 | Ubiquitination | SGTTGSLKRTHEEED CCCCCCEECCCCCCC | 57.88 | - | |
| 214 | Phosphorylation | EEEDDFGTMQVATAQ CCCCCCCCEEHHHCC | 12.39 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of STYX_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of STYX_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of STYX_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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