dbPTM

FBX38_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FBX38_HUMAN
UniProt AC	Q6PIJ6
Protein Name	F-box only protein 38
Gene Name	FBXO38
Organism	Homo sapiens (Human).
Sequence Length	1188
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity)..
Protein Sequence	MGPRKKSVKTCIMNNEIPEEMTADETKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDASFLTLLKKMPDVEQLYGLHPRYLERRRVRGHEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWTRLVDINLVRCHALKLDSFGQFIELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDDNNAQNNNANIHDNNHHHPDDSDEENDFRQDLQPGEQQFAADALNEMEDIVQEDGEVVAESGNNTPAHSQAIIPVDVDEEQAGPSGLQRVVKPTSITVHDSESDDEEDSLELQEVWIPKNGTRRYSEREEKTGESVQSRELSVSGKGKTPLRKRYNSHQMGQSKQFPLEESSCEKGCQVTSEQIKADMKAARDIPEKKKNKDVYPSCSSTTASTVGNSSSHNTASQSPDFVRTVNSGGSSEPSPTEVDVSRQCACSPGGSEDSEAMEEGDAESSVCPRCCCHRPQESQRRTSRCSDEERPSTSRACVVNGPDGTRSAFSFRTLPQGGSSGPAHDERTNGSGSGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVLLVSESEVAKTKPRHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRSWMDTIANINQELIKYEFFPEATRSEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRAAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKKGVFQRVVAIFIHYCDVNGEPVEDDYI

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
57	Phosphorylation	IMCMECLSRKLKEAV HCHHHHHHHHHHHHH	38.74	30631047
65	Phosphorylation	RKLKEAVTLYLRVVR HHHHHHHHHHHHHHH	19.41	-
214	Phosphorylation	IPMLRHLYMKWVRLT HHHHHHHHHHHHHCC	7.19	-
246	Phosphorylation	MRNCAGPTNSLKYVP HHHCCCCCCCCCHHH	36.20	25072903
248	Phosphorylation	NCAGPTNSLKYVPLV HCCCCCCCCCHHHHH	28.81	25072903
250 (in isoform 3)	Ubiquitination	-	43.98	21890473
250 (in isoform 2)	Ubiquitination	-	43.98	21890473
250	Ubiquitination	AGPTNSLKYVPLVTG CCCCCCCCHHHHHHH	43.98	21890473
250 (in isoform 1)	Ubiquitination	-	43.98	21890473
333	Ubiquitination	RIQPSLTKDGVFSAL CCCCCCCCCCHHHHH	58.75	-
558	Phosphorylation	DGEVVAESGNNTPAH CCCEEEECCCCCCCC	36.76	26074081
562	Phosphorylation	VAESGNNTPAHSQAI EEECCCCCCCCCCCE	26.33	26074081
566	Phosphorylation	GNNTPAHSQAIIPVD CCCCCCCCCCEEECC	24.34	26074081
591	Phosphorylation	LQRVVKPTSITVHDS CCEEECCCEEEEECC	27.35	29116813
592	Phosphorylation	QRVVKPTSITVHDSE CEEECCCEEEEECCC	25.45	29116813
594	Phosphorylation	VVKPTSITVHDSESD EECCCEEEEECCCCC	16.14	29116813
598 (in isoform 2)	Phosphorylation	-	24.91	27251275
598	Phosphorylation	TSITVHDSESDDEED CEEEEECCCCCCCCC	24.91	29116813
600 (in isoform 2)	Phosphorylation	-	55.07	27251275
600	Phosphorylation	ITVHDSESDDEEDSL EEEECCCCCCCCCCE	55.07	29116813
606	Phosphorylation	ESDDEEDSLELQEVW CCCCCCCCEEEEEEE	27.33	20873877
622	Phosphorylation	PKNGTRRYSEREEKT CCCCCCCCCHHHHHC	16.16	26074081
623 (in isoform 2)	Phosphorylation	-	28.50	27251275
623	Phosphorylation	KNGTRRYSEREEKTG CCCCCCCCHHHHHCC	28.50	26074081
628	Ubiquitination	RYSEREEKTGESVQS CCCHHHHHCCCCHHC	58.01	-
639 (in isoform 2)	Phosphorylation	-	14.97	27251275
639	Phosphorylation	SVQSRELSVSGKGKT CHHCCCCCCCCCCCC	14.97	23312004
652	Phosphorylation	KTPLRKRYNSHQMGQ CCCHHHHCCCCCCCC	24.85	27794612
654	Phosphorylation	PLRKRYNSHQMGQSK CHHHHCCCCCCCCCC	13.23	25849741
654 (in isoform 2)	Phosphorylation	-	13.23	27251275
660	Phosphorylation	NSHQMGQSKQFPLEE CCCCCCCCCCCCCCC	23.77	27794612
686	Methylation	EQIKADMKAARDIPE HHHHHHHHHHHCCCH	39.17	-
701	Phosphorylation	KKKNKDVYPSCSSTT HHCCCCCCCCCCCCC	10.28	23927012
703	Phosphorylation	KNKDVYPSCSSTTAS CCCCCCCCCCCCCCC	14.67	28450419
705	Phosphorylation	KDVYPSCSSTTASTV CCCCCCCCCCCCCCC	34.75	28450419
706	Phosphorylation	DVYPSCSSTTASTVG CCCCCCCCCCCCCCC	33.82	28450419
707	Phosphorylation	VYPSCSSTTASTVGN CCCCCCCCCCCCCCC	15.30	28450419
708	Phosphorylation	YPSCSSTTASTVGNS CCCCCCCCCCCCCCC	22.13	23663014
710	Phosphorylation	SCSSTTASTVGNSSS CCCCCCCCCCCCCCC	22.87	23663014
711	Phosphorylation	CSSTTASTVGNSSSH CCCCCCCCCCCCCCC	29.93	23663014
715	Phosphorylation	TASTVGNSSSHNTAS CCCCCCCCCCCCCCC	27.56	30278072
716	Phosphorylation	ASTVGNSSSHNTASQ CCCCCCCCCCCCCCC	39.35	30278072
717	Phosphorylation	STVGNSSSHNTASQS CCCCCCCCCCCCCCC	22.15	30278072
720	Phosphorylation	GNSSSHNTASQSPDF CCCCCCCCCCCCCCC	23.43	23663014
722	Phosphorylation	SSSHNTASQSPDFVR CCCCCCCCCCCCCEE	29.20	30278072
724	Phosphorylation	SHNTASQSPDFVRTV CCCCCCCCCCCEEEC	24.76	30278072
724 (in isoform 2)	Phosphorylation	-	24.76	27251275
730	Phosphorylation	QSPDFVRTVNSGGSS CCCCCEEECCCCCCC	20.81	21712546
733	Phosphorylation	DFVRTVNSGGSSEPS CCEEECCCCCCCCCC	39.95	30266825
736	Phosphorylation	RTVNSGGSSEPSPTE EECCCCCCCCCCCCE	34.75	30266825
736 (in isoform 2)	Phosphorylation	-	34.75	27251275
737	Phosphorylation	TVNSGGSSEPSPTEV ECCCCCCCCCCCCEE	57.72	30266825
740	Phosphorylation	SGGSSEPSPTEVDVS CCCCCCCCCCEEEEC	40.16	25159151
740 (in isoform 2)	Phosphorylation	-	40.16	27251275
742	Phosphorylation	GSSEPSPTEVDVSRQ CCCCCCCCEEEECCC	53.64	30266825
747	Phosphorylation	SPTEVDVSRQCACSP CCCEEEECCCCCCCC	16.51	30266825
753 (in isoform 2)	Phosphorylation	-	14.19	27251275
753	Phosphorylation	VSRQCACSPGGSEDS ECCCCCCCCCCCCCH	14.19	28450419
757	Phosphorylation	CACSPGGSEDSEAME CCCCCCCCCCHHHHH	44.11	28450419
760	Phosphorylation	SPGGSEDSEAMEEGD CCCCCCCHHHHHHCC	24.17	30576142
760 (in isoform 2)	Phosphorylation	-	24.17	27251275
770	Phosphorylation	MEEGDAESSVCPRCC HHHCCCCCCCCCCHH	29.77	30177828
771	Phosphorylation	EEGDAESSVCPRCCC HHCCCCCCCCCCHHC	21.17	30177828
788	Phosphorylation	PQESQRRTSRCSDEE CHHHHCHHCCCCCCC	23.78	23312004
789	Phosphorylation	QESQRRTSRCSDEER HHHHCHHCCCCCCCC	29.49	23312004
792	Phosphorylation	QRRTSRCSDEERPST HCHHCCCCCCCCCCC	47.12	30576142
792 (in isoform 2)	Phosphorylation	-	47.12	27251275
798	Phosphorylation	CSDEERPSTSRACVV CCCCCCCCCCCEEEE	45.28	23312004
799	Phosphorylation	SDEERPSTSRACVVN CCCCCCCCCCEEEEC	25.55	29449344
800	Phosphorylation	DEERPSTSRACVVNG CCCCCCCCCEEEECC	23.40	24719451
816	Phosphorylation	DGTRSAFSFRTLPQG CCCCEEEEEEECCCC	17.34	24719451
825	Phosphorylation	RTLPQGGSSGPAHDE EECCCCCCCCCCCCC	38.66	28985074
826	Phosphorylation	TLPQGGSSGPAHDER ECCCCCCCCCCCCCC	52.66	28674419
833 (in isoform 2)	Phosphorylation	-	39.28	27251275
834	Phosphorylation	GPAHDERTNGSGSGA CCCCCCCCCCCCCCC	41.71	-
837	Phosphorylation	HDERTNGSGSGATGE CCCCCCCCCCCCCCC	31.68	-
839	Phosphorylation	ERTNGSGSGATGEDR CCCCCCCCCCCCCCC	27.27	-
842	Phosphorylation	NGSGSGATGEDRRGS CCCCCCCCCCCCCCC	44.63	28985074
849	Phosphorylation	TGEDRRGSSQPESCD CCCCCCCCCCCCCCC	24.80	28634298
850	Phosphorylation	GEDRRGSSQPESCDV CCCCCCCCCCCCCCC	53.21	28634298
854	Phosphorylation	RGSSQPESCDVQSNE CCCCCCCCCCCCCCC	23.46	26657352
863	Phosphorylation	DVQSNEDYPRRPLTR CCCCCCCCCCCHHHH	7.77	27067055
873	Phosphorylation	RPLTRARSRLSHVLL CHHHHHHHHHCEEEE	36.27	28555341
876	Phosphorylation	TRARSRLSHVLLVSE HHHHHHHCEEEEECH	15.50	30576142
903	Acetylation	KRKRTADKSTSTSDP HHCCCCCCCCCCCCC	53.84	25953088
904	Phosphorylation	RKRTADKSTSTSDPV HCCCCCCCCCCCCCC	28.30	27251275
905	Phosphorylation	KRTADKSTSTSDPVI CCCCCCCCCCCCCCC	41.59	27251275
906	Phosphorylation	RTADKSTSTSDPVIE CCCCCCCCCCCCCCC	32.76	27251275
907	Phosphorylation	TADKSTSTSDPVIED CCCCCCCCCCCCCCC	36.92	27251275
908	Phosphorylation	ADKSTSTSDPVIEDD CCCCCCCCCCCCCCC	39.42	27251275
938	Phosphorylation	TMTNCGITDLVLKDC EEECCCCHHHHHCCC	14.47	-
960	Acetylation	ATRCRVLKHLKVENA HHHHHHHHHCCCCCC	43.99	26051181
980	Ubiquitination	FDYAQCKKLNMDQVL CCHHHHHHCCHHHHH	53.36	-
1051	Phosphorylation	RIRSWMDTIANINQE HHHHHHHHHHHHCHH	13.09	-
1149	Phosphorylation	SADICMETIGEEISE CCHHHHHHHHHHHHH	13.85	22468782
1155	Phosphorylation	ETIGEEISEMRQMKK HHHHHHHHHHHHHHH	28.72	22468782
1187	Phosphorylation	GEPVEDDYI------ CCCCCCCCC------	22.35	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FBX38_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FBX38_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FBX38_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KLF7_HUMAN	KLF7	physical	14729953
A4_HUMAN	APP	physical	21832049
RING1_HUMAN	RING1	physical	21988832
PPM1G_HUMAN	PPM1G	physical	21988832
SOX30_HUMAN	SOX30	physical	21988832

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615575	Neuronopathy, distal hereditary motor, 2D (HMN2D)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FBX38_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-736, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-737 AND THR-742, ANDMASS SPECTROMETRY.	18669648 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-740, AND MASSSPECTROMETRY.	15302935 [Abstract]