KLF7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KLF7_HUMAN
• UniProt AC: O75840
• Protein Name: Krueppel-like factor 7
• Gene Name: KLF7
• Organism: Homo sapiens (Human).
• Sequence Length: 302
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator. Binds in vitro to the CACCC motif of the beta-globin promoter and to the SP1 recognition sequence..
• Protein Sequence: MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDCFLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLDSYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGGVATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQRTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKRHI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2 (in isoform 2)	Phosphorylation	-	44.10	23663014
9 (in isoform 2)	Phosphorylation	-	2.91	23663014
42	Phosphorylation	TCLELERYLQTEPRR HHHHHHHHHHCCCCH	8.19	23663014
45	Phosphorylation	ELERYLQTEPRRISE HHHHHHHCCCCHHHH	45.41	-
151	Phosphorylation	LSRHLVKTSQTLSAV HHHHHHHHCCCCCCC	20.70	22210691
189	Phosphorylation	ATAAAAVTAAGAVKS HHHHHHHHHHHHHHC	13.18	-
196	Phosphorylation	TAAGAVKSGQSDSDQ HHHHHHHCCCCCCCC	35.15	-
199	Phosphorylation	GAVKSGQSDSDQGGL HHHHCCCCCCCCCCC	42.48	-
201	Phosphorylation	VKSGQSDSDQGGLGA HHCCCCCCCCCCCCC	36.76	-
232	Acetylation	GCRKVYTKSSHLKAH CCCEEEECCHHHHHH	32.07	16230382
237	Acetylation	YTKSSHLKAHQRTHT EECCHHHHHHCCCCC	38.10	16230382
242	Phosphorylation	HLKAHQRTHTGEKPY HHHHHCCCCCCCCCC	19.74	28348404
244	Phosphorylation	KAHQRTHTGEKPYKC HHHCCCCCCCCCCCC	46.56	26270265
247	Ubiquitination	QRTHTGEKPYKCSWE CCCCCCCCCCCCCCC	55.80	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KLF7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KLF7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KLF7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FBX38_HUMAN	FBXO38	physical	14729953
A4_HUMAN	APP	physical	21832049

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.