F172A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: F172A_HUMAN
• UniProt AC: Q8WUF8
• Protein Name: Protein FAM172A
• Gene Name: FAM172A
• Organism: Homo sapiens (Human).
• Sequence Length: 416
• Subcellular Localization: Secreted .
• Protein Sequence: MSISLSSLILLPIWINMAQIQQGGPDEKEKTTALKDLLSRIDLDELMKKDEPPLDFPDTLEGFEYAFNEKGQLRHIKTGEPFVFNYREDLHRWNQKRYEALGEIITKYVYELLEKDCNLKKVSIPVDATESEPKSFIFMSEDALTNPQKLMVLIHGSGVVRAGQWARRLIINEDLDSGTQIPFIKRAVAEGYGVIVLNPNENYIEVEKPKIHVQSSSDSSDEPAEKRERKDKVSKETKKRRDFYEKYRNPQREKEMMQLYIRENGSPEEHAIYVWDHFIAQAAAENVFFVAHSYGGLAFVELMIQREADVKNKVTAVALTDSVHNVWHQEAGKTIREWMRENCCNWVSSSEPLDTSVESMLPDCPRVSAGTDRHELTSWKSFPSIFKFFTEASEAKTSSLKPAVTRRSHRIKHEEL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
35 (in isoform 2)	Ubiquitination	-	43.81	21890473
35 (in isoform 1)	Ubiquitination	-	43.81	21890473
35	Ubiquitination	KEKTTALKDLLSRID HHHHHHHHHHHHCCC	43.81	21890473
39	Phosphorylation	TALKDLLSRIDLDEL HHHHHHHHCCCHHHH	34.19	28060719
48	Ubiquitination	IDLDELMKKDEPPLD CCHHHHHCCCCCCCC	70.47	-
49	Ubiquitination	DLDELMKKDEPPLDF CHHHHHCCCCCCCCC	54.05	-
98	Phosphorylation	HRWNQKRYEALGEII HHHHHHHHHHHHHHH	16.76	-
121	Ubiquitination	EKDCNLKKVSIPVDA HHHCCCCEEECCCCC	44.36	-
123	Phosphorylation	DCNLKKVSIPVDATE HCCCCEEECCCCCCC	30.01	29083192
129	Phosphorylation	VSIPVDATESEPKSF EECCCCCCCCCCCCE	35.26	29083192
131	Phosphorylation	IPVDATESEPKSFIF CCCCCCCCCCCCEEE	55.64	29083192
135	Phosphorylation	ATESEPKSFIFMSED CCCCCCCCEEEECCC	34.00	29083192
140	Phosphorylation	PKSFIFMSEDALTNP CCCEEEECCCCCCCC	22.90	29083192
145	Phosphorylation	FMSEDALTNPQKLMV EECCCCCCCCCEEEE	46.72	29083192
185	Ubiquitination	GTQIPFIKRAVAEGY CCCCHHHHHHHHCCC	34.38	-
215	Phosphorylation	KPKIHVQSSSDSSDE CCEEEEECCCCCCCC	30.62	20363803
216	Phosphorylation	PKIHVQSSSDSSDEP CEEEEECCCCCCCCH	22.52	25159151
217	Phosphorylation	KIHVQSSSDSSDEPA EEEEECCCCCCCCHH	46.92	25159151
219	Phosphorylation	HVQSSSDSSDEPAEK EEECCCCCCCCHHHH	41.45	25159151
220	Phosphorylation	VQSSSDSSDEPAEKR EECCCCCCCCHHHHH	51.49	25159151
223	Ubiquitination	SSDSSDEPAEKRERK CCCCCCCHHHHHHHH	51.19	21890473
260	Phosphorylation	EKEMMQLYIRENGSP HHHHHHHHHHHCCCH	4.89	25159151
287	Ubiquitination	AQAAAENVFFVAHSY HHHHHHCCEEEEECC	2.72	21890473
333 (in isoform 1)	Ubiquitination	-	48.07	21890473
333	Ubiquitination	VWHQEAGKTIREWMR HHHHHHHHHHHHHHH	48.07	21890473
381	Phosphorylation	HELTSWKSFPSIFKF HHHCCCHHCHHHHHH	35.81	27499020
384	Phosphorylation	TSWKSFPSIFKFFTE CCCHHCHHHHHHHHH	38.35	24719451
401	Acetylation	EAKTSSLKPAVTRRS HHHCCCCCHHHCCCH	32.64	25953088
408	Phosphorylation	KPAVTRRSHRIKHEE CHHHCCCHHHCCCCC	17.52	-
412	Sumoylation	TRRSHRIKHEEL--- CCCHHHCCCCCC---	44.94	-
412	Sumoylation	TRRSHRIKHEEL--- CCCHHHCCCCCC---	44.94	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of F172A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of F172A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of F172A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of F172A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.