HEM6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HEM6_HUMAN
• UniProt AC: P36551
• Protein Name: Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
• Gene Name: CPOX
• Organism: Homo sapiens (Human).
• Sequence Length: 454
• Subcellular Localization: Mitochondrion intermembrane space.
• Protein Description: Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX..
• Protein Sequence: MALQLGRLSSGPCWLVARGGCGGPRAWSQCGGGGLRAWSQRSAAGRVCRPPGPAGTEQSRGLGHGSTSRGGPWVGTGLAAALAGLVGLATAAFGHVQRAEMLPKTSGTRATSLGRPEEEEDELAHRCSSFMAPPVTDLGELRRRPGDMKTKMELLILETQAQVCQALAQVDGGANFSVDRWERKEGGGGISCVLQDGCVFEKAGVSISVVHGNLSEEAAKQMRSRGKVLKTKDGKLPFCAMGVSSVIHPKNPHAPTIHFNYRYFEVEEADGNKQWWFGGGCDLTPTYLNQEDAVHFHRTLKEACDQHGPDLYPKFKKWCDDYFFIAHRGERRGIGGIFFDDLDSPSKEEVFRFVQSCARAVVPSYIPLVKKHCDDSFTPQEKLWQQLRRGRYVEFNLLYDRGTKFGLFTPGSRIESILMSLPLTARWEYMHSPSENSKEAEILEVLRHPRDWVR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Phosphorylation	ALQLGRLSSGPCWLV CCCCCCCCCCCEEEE	31.71	23898821
10	Phosphorylation	LQLGRLSSGPCWLVA CCCCCCCCCCEEEEE	51.88	23898821
108	Phosphorylation	MLPKTSGTRATSLGR HCCCCCCCCCCCCCC	19.52	20068231
111	Phosphorylation	KTSGTRATSLGRPEE CCCCCCCCCCCCCHH	22.61	29255136
112	Phosphorylation	TSGTRATSLGRPEEE CCCCCCCCCCCCHHH	28.04	23401153
127	Glutathionylation	EDELAHRCSSFMAPP HHHHHHHHHHCCCCC	2.61	22555962
184	Ubiquitination	SVDRWERKEGGGGIS EEEEEEECCCCCCEE	49.55	29967540
198	Glutathionylation	SCVLQDGCVFEKAGV EEEEECCCEEEECCC	4.22	22555962
220	Malonylation	NLSEEAAKQMRSRGK CCCHHHHHHHHHCCC	52.23	30639696
220	Ubiquitination	NLSEEAAKQMRSRGK CCCHHHHHHHHHCCC	52.23	21906983
232	Ubiquitination	RGKVLKTKDGKLPFC CCCEEECCCCCCCCE	64.00	-
235	Ubiquitination	VLKTKDGKLPFCAMG EEECCCCCCCCEEEE	64.22	-
298	Methylation	EDAVHFHRTLKEACD HHHHHHHHHHHHHHH	40.59	-
301	Ubiquitination	VHFHRTLKEACDQHG HHHHHHHHHHHHHHC	42.53	29967540
304	Glutathionylation	HRTLKEACDQHGPDL HHHHHHHHHHHCCCC	5.62	22555962
312	Phosphorylation	DQHGPDLYPKFKKWC HHHCCCCHHHHHHHH	16.26	28152594
314	Ubiquitination	HGPDLYPKFKKWCDD HCCCCHHHHHHHHCC	57.15	29967540
319	Glutathionylation	YPKFKKWCDDYFFIA HHHHHHHHCCEEEEE	3.81	22555962
344	Phosphorylation	IFFDDLDSPSKEEVF EEECCCCCCCHHHHH	38.07	27422710
346	Phosphorylation	FDDLDSPSKEEVFRF ECCCCCCCHHHHHHH	57.56	24961811
347	Ubiquitination	DDLDSPSKEEVFRFV CCCCCCCHHHHHHHH	62.37	21906983
356	Phosphorylation	EVFRFVQSCARAVVP HHHHHHHHHHHHHCH	12.39	-
364	Phosphorylation	CARAVVPSYIPLVKK HHHHHCHHHHHHHHH	24.88	28152594
365	Phosphorylation	ARAVVPSYIPLVKKH HHHHCHHHHHHHHHH	10.65	28152594
370	2-Hydroxyisobutyrylation	PSYIPLVKKHCDDSF HHHHHHHHHHCCCCC	44.47	-
370	Ubiquitination	PSYIPLVKKHCDDSF HHHHHHHHHHCCCCC	44.47	21906983
371	Ubiquitination	SYIPLVKKHCDDSFT HHHHHHHHHCCCCCC	41.82	22817900
373	Glutathionylation	IPLVKKHCDDSFTPQ HHHHHHHCCCCCCHH	9.50	22555962
392	Phosphorylation	QQLRRGRYVEFNLLY HHHHCCCCEEEEEEE	13.73	28152594
404	Ubiquitination	LLYDRGTKFGLFTPG EEEECCCCCCCCCCC	40.01	21906983
404	Acetylation	LLYDRGTKFGLFTPG EEEECCCCCCCCCCC	40.01	25953088
404	Succinylation	LLYDRGTKFGLFTPG EEEECCCCCCCCCCC	40.01	-
404	Succinylation	LLYDRGTKFGLFTPG EEEECCCCCCCCCCC	40.01	-
404	Malonylation	LLYDRGTKFGLFTPG EEEECCCCCCCCCCC	40.01	26320211
409	Phosphorylation	GTKFGLFTPGSRIES CCCCCCCCCCCHHHH	31.61	23312004
416	Phosphorylation	TPGSRIESILMSLPL CCCCHHHHHHHCCCC	20.74	30108239
420	Phosphorylation	RIESILMSLPLTARW HHHHHHHCCCCEECE	24.32	27050516
424	Phosphorylation	ILMSLPLTARWEYMH HHHCCCCEECEEECC	16.55	20068231
438	Ubiquitination	HSPSENSKEAEILEV CCCCCCCHHHHHHHH	72.95	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HEM6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HEM6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HEM6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UB2G2_HUMAN	UBE2G2	physical	21988832
PEO1_HUMAN	C10orf2	physical	26344197
TRNT1_HUMAN	TRNT1	physical	26344197
SYYC_HUMAN	YARS	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 121300: Hereditary coproporphyria (HCP)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.