PEO1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PEO1_HUMAN
• UniProt AC: Q96RR1
• Protein Name: Twinkle protein, mitochondrial {ECO:0000305}
• Gene Name: TWNK {ECO:0000312|HGNC:HGNC:1160}
• Organism: Homo sapiens (Human).
• Sequence Length: 684
• Subcellular Localization: Mitochondrion matrix, mitochondrion nucleoid . Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression.
• Protein Description: Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity. In vitro, forms in combination with POLG, a processive replication machinery, which can use double-stranded DNA (dsDNA) as template to synthesize single-stranded DNA (ssDNA) molecules. May be a key regulator of mtDNA copy number in mammals..
• Protein Sequence: MWVLLRSGYPLRILLPLRGEWMGRRGLPRNLAPGPPRRRYRKETLQALDMPVLPVTATEIRQYLRGHGIPFQDGHSCLRALSPFAESSQLKGQTGVTTSFSLFIDKTTGHFLCMTSLAEGSWEDFQASVEGRGDGAREGFLLSKAPEFEDSEEVRRIWNRAIPLWELPDQEEVQLADTMFGLTKVTDDTLKRFSVRYLRPARSLVFPWFSPGGSGLRGLKLLEAKCQGDGVSYEETTIPRPSAYHNLFGLPLISRRDAEVVLTSRELDSLALNQSTGLPTLTLPRGTTCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCFLVRPGDQQPRPLEALNGGFNLSRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGLRWSRFPDLNRILKGHRKGELTVFTGPTGSGKTTFISEYALDLCSQGVNTLWGSFEISNVRLARVMLTQFAEGRLEDQLDKYDHWADRFEDLPLYFMTFHGQQSIRTVIDTMQHAVYVYDICHVIIDNLQFMMGHEQLSTDRIAAQDYIIGVFRKFATDNNCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKNKARLKKIKDDTGPVAKKPSSGKKGATTQNSEICSGQAPTPDQPDTSKRSK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
143	Phosphorylation	AREGFLLSKAPEFED HHHCCEECCCCCCCC	28.99	-
144	Ubiquitination	REGFLLSKAPEFEDS HHCCEECCCCCCCCH	68.85	-
178	Phosphorylation	EEVQLADTMFGLTKV HHHHHHHHHHCCEEC	14.59	-
189	Phosphorylation	LTKVTDDTLKRFSVR CEECCHHHHHHHCEE	36.67	-
197	Phosphorylation	LKRFSVRYLRPARSL HHHHCEECCCCCCCE	12.61	25278378
203	Phosphorylation	RYLRPARSLVFPWFS ECCCCCCCEEECCCC	30.87	25278378
210	Phosphorylation	SLVFPWFSPGGSGLR CEEECCCCCCCCCCH	20.83	25278378
214	Phosphorylation	PWFSPGGSGLRGLKL CCCCCCCCCCHHHHH	40.34	25278378
236	Phosphorylation	DGVSYEETTIPRPSA CCCCCCCCCCCCCHH	20.34	27486199
237	Phosphorylation	GVSYEETTIPRPSAY CCCCCCCCCCCCHHH	32.06	27486199
282	Phosphorylation	STGLPTLTLPRGTTC CCCCCEEECCCCCCC	36.88	24719451
358	Phosphorylation	NLSRILRTALPAWHK CHHHHHHHHCHHHHH	29.15	-
365	Ubiquitination	TALPAWHKSIVSFRQ HHCHHHHHHHHHHHH	31.04	-
457	Phosphorylation	RLARVMLTQFAEGRL HHHHHHHHHHHCCCH	11.98	28674151
537	Phosphorylation	DRIAAQDYIIGVFRK CHHHHHHHHHHHHHH	5.16	-
633	Ubiquitination	LTFSIPPKNKARLKK EEEECCCCCHHHHHH	66.77	-
654	Phosphorylation	PVAKKPSSGKKGATT CCCCCCCCCCCCCCC	64.26	23532336

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PEO1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PEO1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PEO1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CLCA_HUMAN	CLTA	physical	26496610
RAD9A_HUMAN	RAD9A	physical	26496610
TRI27_HUMAN	TRIM27	physical	26496610
TPM1_HUMAN	TPM1	physical	26496610
B4GT7_HUMAN	B4GALT7	physical	26496610
CYTSA_HUMAN	SPECC1L	physical	26496610
DCAF8_HUMAN	DCAF8	physical	26496610
E41L5_HUMAN	EPB41L5	physical	26496610
NCOA5_HUMAN	NCOA5	physical	26496610
CHD9_HUMAN	CHD9	physical	26496610
ACTL8_HUMAN	ACTL8	physical	26496610
ARP5L_HUMAN	ARPC5L	physical	26496610
PHLB2_HUMAN	PHLDB2	physical	26496610
LYSM2_HUMAN	LYSMD2	physical	26496610
LG3BP_HUMAN	LGALS3BP	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.