ARP5L_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARP5L_HUMAN
• UniProt AC: Q9BPX5
• Protein Name: Actin-related protein 2/3 complex subunit 5-like protein
• Gene Name: ARPC5L
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Cytoplasm, cytoskeleton.
• Protein Description: May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks..
• Protein Sequence: MARNTLSSRFRRVDIDEFDENKFVDEQEEAAAAAAEPGPDPSEVDGLLRQGDMLRAFHAALRNSPVNTKNQAVKERAQGVVLKVLTNFKSSEIEQAVQSLDRNGVDLLMKYIYKGFEKPTENSSAVLLQWHEKALAVGGLGSIIRVLTARKTV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Methylation	-----MARNTLSSRF -----CCCCHHHHHH	35.05	-
5	Phosphorylation	---MARNTLSSRFRR ---CCCCHHHHHHHC	23.59	29414761
7	Phosphorylation	-MARNTLSSRFRRVD -CCCCHHHHHHHCCC	19.89	25056879
7	O-linked_Glycosylation	-MARNTLSSRFRRVD -CCCCHHHHHHHCCC	19.89	30379171
22	Ubiquitination	IDEFDENKFVDEQEE HHHCCCCCCCCHHHH	44.72	21906983
64	Phosphorylation	FHAALRNSPVNTKNQ HHHHHHCCCCCCCCH	24.64	25159151
68	Phosphorylation	LRNSPVNTKNQAVKE HHCCCCCCCCHHHHH	31.44	23927012
69	Ubiquitination	RNSPVNTKNQAVKER HCCCCCCCCHHHHHH	41.69	21906983
83	Ubiquitination	RAQGVVLKVLTNFKS HHHHHHHHHHHHCCH	24.48	-
86	Phosphorylation	GVVLKVLTNFKSSEI HHHHHHHHHCCHHHH	41.41	27251275
89	Ubiquitination	LKVLTNFKSSEIEQA HHHHHHCCHHHHHHH	55.96	21906983
90	Phosphorylation	KVLTNFKSSEIEQAV HHHHHCCHHHHHHHH	29.12	25307156
91	Phosphorylation	VLTNFKSSEIEQAVQ HHHHCCHHHHHHHHH	43.09	21406692
99	Phosphorylation	EIEQAVQSLDRNGVD HHHHHHHHCHHCCHH	26.16	21406692
110	Ubiquitination	NGVDLLMKYIYKGFE CCHHHHHHHHHHCCC	28.59	21906983
114	Ubiquitination	LLMKYIYKGFEKPTE HHHHHHHHCCCCCCC	47.79	-
118	Acetylation	YIYKGFEKPTENSSA HHHHCCCCCCCCCCC	55.78	26051181
118	Ubiquitination	YIYKGFEKPTENSSA HHHHCCCCCCCCCCC	55.78	-
142	Phosphorylation	LAVGGLGSIIRVLTA HHHCCHHHHHHHHHH	21.64	21712546
148	Phosphorylation	GSIIRVLTARKTV-- HHHHHHHHHCCCC--	22.89	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARP5L_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARP5L_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARP5L_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARPC4_HUMAN	ARPC4	physical	16169070
ARPC4_HUMAN	ARPC4	physical	22939629
ARPC2_HUMAN	ARPC2	physical	22939629
ARPC3_HUMAN	ARPC3	physical	22939629
GA45G_HUMAN	GADD45G	physical	21988832
ARPC2_HUMAN	ARPC2	physical	22863883
ARPC3_HUMAN	ARPC3	physical	22863883
ARPC4_HUMAN	ARPC4	physical	22863883
ARPC5_HUMAN	ARPC5	physical	22863883
KAPCA_HUMAN	PRKACA	physical	22863883
TM10A_HUMAN	TRMT10A	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
ARP3_HUMAN	ACTR3	physical	26344197
ARC1A_HUMAN	ARPC1A	physical	26344197
ARPC2_HUMAN	ARPC2	physical	26344197
ARPC4_HUMAN	ARPC4	physical	26344197
CAPZB_HUMAN	CAPZB	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND MASSSPECTROMETRY.
PubMed: 17081983