TM10A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM10A_HUMAN
• UniProt AC: Q8TBZ6
• Protein Name: tRNA methyltransferase 10 homolog A
• Gene Name: TRMT10A
• Organism: Homo sapiens (Human).
• Sequence Length: 339
• Subcellular Localization: Nucleus . Nucleus, nucleolus .
• Protein Description: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. [PubMed: 23042678]
• Protein Sequence: MSSEMLPAFIETSNVDKKQGINEDQEESQKPRLGEGCEPISKRQMKKLIKQKQWEEQRELRKQKRKEKRKRKKLERQCQMEPNSDGHDRKRVRRDVVHSTLRLIIDCSFDHLMVLKDIKKLHKQIQRCYAENRRALHPVQFYLTSHGGQLKKNMDENDKGWVNWKDIHIKPEHYSELIKKEDLIYLTSDSPNILKELDESKAYVIGGLVDHNHHKGLTYKQASDYGINHAQLPLGNFVKMNSRKVLAVNHVFEIILEYLETRDWQEAFFTILPQRKGAVPTDKACESASHDNQSVRMEEGGSDSDSSEEEYSRNELDSPHEEKQDKENHTESTVNSLPH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSEMLPAF ------CCCCCHHHH		29083192
3	Phosphorylation	-----MSSEMLPAFI -----CCCCCHHHHH		24719451
12	Phosphorylation	MLPAFIETSNVDKKQ CHHHHHHHCCCCHHC		26552605
13	Phosphorylation	LPAFIETSNVDKKQG HHHHHHHCCCCHHCC		26552605
28	Phosphorylation	INEDQEESQKPRLGE CCCCHHHHCCCCCCC		29255136
84	Phosphorylation	QCQMEPNSDGHDRKR HHCCCCCCCCCCCHH		-
99	Phosphorylation	VRRDVVHSTLRLIID HHHHHHHHHHHHHHH		22210691
100	Phosphorylation	RRDVVHSTLRLIIDC HHHHHHHHHHHHHHC		22210691
144	Phosphorylation	HPVQFYLTSHGGQLK CCEEEEEECCCCHHC		-
170	Acetylation	NWKDIHIKPEHYSEL CHHHEEECHHHHHHH		25953088
287	Phosphorylation	PTDKACESASHDNQS CCCHHHHHCCCCCCC		28634120
294	Phosphorylation	SASHDNQSVRMEEGG HCCCCCCCEECCCCC		25849741
302	Phosphorylation	VRMEEGGSDSDSSEE EECCCCCCCCCCCHH		20363803
304	Phosphorylation	MEEGGSDSDSSEEEY CCCCCCCCCCCHHHH		20363803
306	Phosphorylation	EGGSDSDSSEEEYSR CCCCCCCCCHHHHHH		20363803
307	Phosphorylation	GGSDSDSSEEEYSRN CCCCCCCCHHHHHHC		20363803
311	Phosphorylation	SDSSEEEYSRNELDS CCCCHHHHHHCCCCC		-
312	Phosphorylation	DSSEEEYSRNELDSP CCCHHHHHHCCCCCC		24114839
318	Phosphorylation	YSRNELDSPHEEKQD HHHCCCCCCCHHHHH		29255136
330	Phosphorylation	KQDKENHTESTVNSL HHHHHCCCHHHHHCC		23186163
332	Phosphorylation	DKENHTESTVNSLPH HHHCCCHHHHHCCCC		23186163
333	Phosphorylation	KENHTESTVNSLPH- HHCCCHHHHHCCCC-		23186163
336	Phosphorylation	HTESTVNSLPH---- CCHHHHHCCCC----		25053765

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM10A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM10A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM10A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AASD1_HUMAN	AARSD1	physical	22863883
ARPC3_HUMAN	ARPC3	physical	22863883
2A5E_HUMAN	PPP2R5E	physical	22863883
KAPCA_HUMAN	PRKACA	physical	22863883
SAE1_HUMAN	SAE1	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 616033: Microcephaly, short stature, and impaired glucose metabolism (MSSGM)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.