ARC1A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARC1A_HUMAN
• UniProt AC: Q92747
• Protein Name: Actin-related protein 2/3 complex subunit 1A
• Gene Name: ARPC1A
• Organism: Homo sapiens (Human).
• Sequence Length: 370
• Subcellular Localization: Cytoplasm, cytoskeleton .
• Protein Description: Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks..
• Protein Sequence: MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITGIDWAPKSDRIVTCGADRNAYVWSQKDGVWKPTLVILRINRAATFVKWSPLENKFAVGSGARLISVCYFESENDWWVSKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRVFSAYIKEVDEKPASTPWGSKMPFGQLMSEFGGSGTGGWVHGVSFSASGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSENSVVAAGHDCCPMLFNYDDRGCLTFVSKLDIPKQSIQRNMSAMERFRNMDKRATTEDRNTALETLHQNSITQVSIYEVDKQDCRKFCTTGIDGAMTIWDFKTLESSIQGLRIM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSLHQFLLE ------CCHHHHHHC	34.26	25159151
26	Phosphorylation	DRTQIALSPNNHEVH CCCEEEECCCCCEEE	19.29	-
40	Ubiquitination	HIYKKNGSQWVKAHE EEEEECCCCEEEEEE	30.20	21890473
44	Ubiquitination	KNGSQWVKAHELKEH ECCCCEEEEEEHHHC	40.86	-
49	Ubiquitination	WVKAHELKEHNGHIT EEEEEEHHHCCCEEC	54.68	-
56	Ubiquitination	KEHNGHITGIDWAPK HHCCCEECCCCCCCC	23.55	-
63	Ubiquitination	TGIDWAPKSDRIVTC CCCCCCCCCCCEEEE	58.19	21890473
63	Ubiquitination	TGIDWAPKSDRIVTC CCCCCCCCCCCEEEE	58.19	21890473
63	Ubiquitination	TGIDWAPKSDRIVTC CCCCCCCCCCCEEEE	58.19	-
74	Methylation	IVTCGADRNAYVWSQ EEEECCCCCEEEEEC	29.19	-
77	Phosphorylation	CGADRNAYVWSQKDG ECCCCCEEEEECCCC	13.15	20068231
80	Phosphorylation	DRNAYVWSQKDGVWK CCCEEEEECCCCCCC	19.80	20068231
87	Ubiquitination	SQKDGVWKPTLVILR ECCCCCCCCEEEEEE	26.22	21890473
87	Ubiquitination	SQKDGVWKPTLVILR ECCCCCCCCEEEEEE	26.22	21890473
103	Ubiquitination	NRAATFVKWSPLENK CCCCEEEECCCCCCC	37.45	21906983
110	Ubiquitination	KWSPLENKFAVGSGA ECCCCCCCCCCCCCC	25.89	21890473
127	Acetylation	ISVCYFESENDWWVS EEEEEEECCCCEEEE	31.62	-
132	Acetylation	FESENDWWVSKHIKK EECCCCEEEEHHCCC	6.33	-
132	Ubiquitination	FESENDWWVSKHIKK EECCCCEEEEHHCCC	6.33	-
138	Ubiquitination	WWVSKHIKKPIRSTV EEEEHHCCCCCCCEE	52.82	-
170	Phosphorylation	DFKCRVFSAYIKEVD CCEEEEEEEEEEECC	19.80	24719451
174	Malonylation	RVFSAYIKEVDEKPA EEEEEEEEECCCCCC	38.72	26320211
174	Acetylation	RVFSAYIKEVDEKPA EEEEEEEEECCCCCC	38.72	23749302
179	Ubiquitination	YIKEVDEKPASTPWG EEEECCCCCCCCCCC	41.23	21906983
179	Acetylation	YIKEVDEKPASTPWG EEEECCCCCCCCCCC	41.23	23954790
179	Malonylation	YIKEVDEKPASTPWG EEEECCCCCCCCCCC	41.23	26320211
188	Ubiquitination	ASTPWGSKMPFGQLM CCCCCCCCCCHHHHH	46.80	-
235	Ubiquitination	VSVADASKSVQVSTL CCHHHHCCCEEEEEC	57.26	21890473
236	Phosphorylation	SVADASKSVQVSTLK CHHHHCCCEEEEECC	18.45	26657352
240	Phosphorylation	ASKSVQVSTLKTEFL HCCCEEEEECCCCCC	15.78	21406692
241	Phosphorylation	SKSVQVSTLKTEFLP CCCEEEEECCCCCCE	33.16	21406692
243	Ubiquitination	SVQVSTLKTEFLPLL CEEEEECCCCCCEEE	46.20	21890473
290	Ubiquitination	VSKLDIPKQSIQRNM HHCCCCCHHHHHHCH	57.94	21890473
290	Ubiquitination	VSKLDIPKQSIQRNM HHCCCCCHHHHHHCH	57.94	21890473
290	Malonylation	VSKLDIPKQSIQRNM HHCCCCCHHHHHHCH	57.94	26320211
298	Phosphorylation	QSIQRNMSAMERFRN HHHHHCHHHHHHHHC	28.19	23401153
308	Acetylation	ERFRNMDKRATTEDR HHHHCCCCCCCHHHH	32.91	26051181
311	Phosphorylation	RNMDKRATTEDRNTA HCCCCCCCHHHHHHH	34.45	22210691
326	Phosphorylation	LETLHQNSITQVSIY HHHHHHCCCEEEEEE	22.05	22210691
328	Phosphorylation	TLHQNSITQVSIYEV HHHHCCCEEEEEEEE	23.80	22210691
342	Acetylation	VDKQDCRKFCTTGID ECHHHHHHHCCCCCC	51.64	25953088
358	Ubiquitination	AMTIWDFKTLESSIQ CEEEEHHHHHHHHHC	50.13	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARC1A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARC1A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARC1A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARP2_HUMAN	ACTR2	physical	22939629
ARPC2_HUMAN	ARPC2	physical	22939629
ARPC4_HUMAN	ARPC4	physical	22939629
ARPC3_HUMAN	ARPC3	physical	22939629
ARP3_HUMAN	ACTR3	physical	22939629
ARP5L_HUMAN	ARPC5L	physical	22939629
ARPC5_HUMAN	ARPC5	physical	22939629
CNDP2_HUMAN	CNDP2	physical	22939629
OLA1_HUMAN	OLA1	physical	22939629
AASD1_HUMAN	AARSD1	physical	22863883
AGFG1_HUMAN	AGFG1	physical	22863883
GON7_HUMAN	C14orf142	physical	22863883
CALR_HUMAN	CALR	physical	22863883
CALU_HUMAN	CALU	physical	22863883
METH_HUMAN	MTR	physical	22863883
2AAB_HUMAN	PPP2R1B	physical	22863883
KAPCA_HUMAN	PRKACA	physical	22863883
TM10A_HUMAN	TRMT10A	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
THG1_HUMAN	THG1L	physical	22863883
TPD54_HUMAN	TPD52L2	physical	22863883
TPRKB_HUMAN	TPRKB	physical	22863883
ARPC2_HUMAN	ARPC2	physical	26186194
CND3_HUMAN	NCAPG	physical	26186194
CND1_HUMAN	NCAPD2	physical	26186194
ARPC5_HUMAN	ARPC5	physical	26186194
CND2_HUMAN	NCAPH	physical	26186194
ARP2_HUMAN	ACTR2	physical	26186194
ARP3B_HUMAN	ACTR3B	physical	26186194
ARP3_HUMAN	ACTR3	physical	26186194
ARP2_HUMAN	ACTR2	physical	26344197
ARP3_HUMAN	ACTR3	physical	26344197
ARPC2_HUMAN	ARPC2	physical	26344197
ARPC3_HUMAN	ARPC3	physical	26344197
ARP3B_HUMAN	ACTR3B	physical	28514442
CND1_HUMAN	NCAPD2	physical	28514442
CND3_HUMAN	NCAPG	physical	28514442
ARP3_HUMAN	ACTR3	physical	28514442
CND2_HUMAN	NCAPH	physical	28514442
ARP2_HUMAN	ACTR2	physical	28514442
ARPC2_HUMAN	ARPC2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.