THG1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THG1_HUMAN
• UniProt AC: Q9NWX6
• Protein Name: Probable tRNA(His) guanylyltransferase
• Gene Name: THG1L
• Organism: Homo sapiens (Human).
• Sequence Length: 298
• Subcellular Localization: Cytoplasm . Found near the nuclear membrane.
• Protein Description: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis..
• Protein Sequence: MWGACKVKVHDSLATISITLRRYLRLGATMAKSKFEYVRDFEADDTCLAHCWVVVRLDGRNFHRFAEKHNFAKPNDSRALQLMTKCAQTVMEELEDIVIAYGQSDEYSFVFKRKTNWFKRRASKFMTHVASQFASSYVFYWRDYFEDQPLLYPPGFDGRVVVYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQGRLQGTLAADKNEILFSEFNINYNNELPMYRKGTVLIWQKVDEVMTKEIKLPTEMEGKKMAVTRTRTKPVPLHCDIIGDAFWKEHPEILDEDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	O-linked_Glycosylation	LGATMAKSKFEYVRD HCCEEECCCCEECCC	32.79	30379171
34	Acetylation	GATMAKSKFEYVRDF CCEEECCCCEECCCC	41.32	25953088
68	Acetylation	NFHRFAEKHNFAKPN CHHHHHHHCCCCCCC	40.18	19608861
73	Ubiquitination	AEKHNFAKPNDSRAL HHHCCCCCCCHHHHH	39.97	-
114	Acetylation	YSFVFKRKTNWFKRR CEEEEECCCCHHHHH	46.96	7377641
119	Ubiquitination	KRKTNWFKRRASKFM ECCCCHHHHHHHHHH	32.37	21890473
119	Acetylation	KRKTNWFKRRASKFM ECCCCHHHHHHHHHH	32.37	7377651
170	Ubiquitination	YPSNQTLKDYLSWRQ ECCCCCHHHHHHHHH	47.95	-
174	Phosphorylation	QTLKDYLSWRQADCH CCHHHHHHHHHCCCH	17.62	24719451
222	Phosphorylation	DKNEILFSEFNINYN CCCCEEEEEECCCCC	37.52	20068231
228	Phosphorylation	FSEFNINYNNELPMY EEEECCCCCCCCCCC	18.63	20068231
235	Phosphorylation	YNNELPMYRKGTVLI CCCCCCCCCCCEEEE	13.77	20068231
237	Malonylation	NELPMYRKGTVLIWQ CCCCCCCCCEEEEEE	41.25	26320211
239	Phosphorylation	LPMYRKGTVLIWQKV CCCCCCCEEEEEEEH	18.38	-
251	Phosphorylation	QKVDEVMTKEIKLPT EEHHHHHHCCCCCCC	30.60	-
252	Ubiquitination	KVDEVMTKEIKLPTE EHHHHHHCCCCCCCC	39.07	21890473
263	Acetylation	LPTEMEGKKMAVTRT CCCCCCCCEEEEEEC	26.52	23749302
263	2-Hydroxyisobutyrylation	LPTEMEGKKMAVTRT CCCCCCCCEEEEEEC	26.52	-
264	Acetylation	PTEMEGKKMAVTRTR CCCCCCCEEEEEECC	42.84	7339661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THG1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THG1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THG1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ELMD1_HUMAN	ELMOD1	physical	16189514
AASD1_HUMAN	AARSD1	physical	22863883
DPP9_HUMAN	DPP9	physical	22863883
EF2K_HUMAN	EEF2K	physical	22863883
METH_HUMAN	MTR	physical	22863883
RAGP1_HUMAN	RANGAP1	physical	22863883
SH3G1_HUMAN	SH3GL1	physical	22863883
SHLB1_HUMAN	SH3GLB1	physical	22863883
TPRKB_HUMAN	TPRKB	physical	22863883
THG1_HUMAN	THG1L	physical	25416956
THG1_HUMAN	THG1L	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-68, AND MASS SPECTROMETRY.
PubMed: 19608861