GON7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GON7_HUMAN
• UniProt AC: Q9BXV9
• Protein Name: EKC/KEOPS complex subunit GON7 {ECO:0000305}
• Gene Name: GON7 {ECO:0000312|HGNC:HGNC:20356}
• Organism: Homo sapiens (Human).
• Sequence Length: 100
• Subcellular Localization: Nucleus .
• Protein Description: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit OSGEP in the complex..
• Protein Sequence: MELLGEYVGQEGKPQKLRVSCEAPGDGDPFQGLLSGVAQMKDMVTELFDPLVQGEVQHRVAAAPDEDLDGDDEDDAEDENNIDNRTNFDGPSAKRPKTPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MELLGEYV -------CCCHHHHC		22814378
13	Ubiquitination	EYVGQEGKPQKLRVS HHCCCCCCCCEEEEE		24816145
20	Phosphorylation	KPQKLRVSCEAPGDG CCCEEEEEEECCCCC		27690223
35	Phosphorylation	DPFQGLLSGVAQMKD CHHHHHHHHHHHHHH		25022875
92	Phosphorylation	RTNFDGPSAKRPKTP CCCCCCCCCCCCCCC		26074081
94	Acetylation	NFDGPSAKRPKTPS- CCCCCCCCCCCCCC-		25953088
94	Ubiquitination	NFDGPSAKRPKTPS- CCCCCCCCCCCCCC-		24816145
97	Ubiquitination	GPSAKRPKTPS---- CCCCCCCCCCC----		24816145
98	Phosphorylation	PSAKRPKTPS----- CCCCCCCCCC-----		30576142
100	Phosphorylation	AKRPKTPS------- CCCCCCCC-------		30576142

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GON7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GON7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GON7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GPN1_HUMAN	GPN1	physical	22863883
HSF1_HUMAN	HSF1	physical	22863883
HPBP1_HUMAN	HSPBP1	physical	22863883
OGT1_HUMAN	OGT	physical	22863883
PPME1_HUMAN	PPME1	physical	22863883
TPRKB_HUMAN	TPRKB	physical	22863883

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.