dbPTM

PHLB2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PHLB2_HUMAN
UniProt AC	Q86SQ0
Protein Name	Pleckstrin homology-like domain family B member 2
Gene Name	PHLDB2
Organism	Homo sapiens (Human).
Sequence Length	1253
Subcellular Localization	Cytoplasm . Membrane Peripheral membrane protein . Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments.
Protein Description	Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity)..
Protein Sequence	MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEEHSYIQKELD ---CCCHHHHHHHHC	27.49	24043423
6	Phosphorylation	--MEEHSYIQKELDL --CCCHHHHHHHHCC	14.85	24043423
6 (in isoform 3)	Phosphorylation	-	14.85	29523821
17	Phosphorylation	ELDLQNGSLEEDSVV HHCCCCCCCCCCCEE	39.91	26425664
32 (in isoform 3)	Phosphorylation	-	44.71	25106551
33 (in isoform 3)	Phosphorylation	-	35.40	27642862
37	Phosphorylation	DSQNMMESLSPKKYS CCHHHHHHCCCCCCC	19.09	24719451
39	Phosphorylation	QNMMESLSPKKYSSS HHHHHHCCCCCCCCC	43.91	28192239
43	Phosphorylation	ESLSPKKYSSSLRFK HHCCCCCCCCCCEEE	21.66	23312004
44	Phosphorylation	SLSPKKYSSSLRFKA HCCCCCCCCCCEEEE	23.48	23312004
45	Phosphorylation	LSPKKYSSSLRFKAN CCCCCCCCCCEEEEC	30.24	23312004
46	Phosphorylation	SPKKYSSSLRFKANG CCCCCCCCCEEEECC	20.02	23312004
50	Methylation	YSSSLRFKANGDYSG CCCCCEEEECCCCCC	34.21	115974969
55	Phosphorylation	RFKANGDYSGSYLTL EEEECCCCCCCEEEE	19.14	21945579
56	Phosphorylation	FKANGDYSGSYLTLS EEECCCCCCCEEEEC	26.46	21945579
58	Phosphorylation	ANGDYSGSYLTLSQP ECCCCCCCEEEECCC	15.84	21945579
59	Phosphorylation	NGDYSGSYLTLSQPV CCCCCCCEEEECCCC	13.77	21945579
61	Phosphorylation	DYSGSYLTLSQPVPA CCCCCEEEECCCCCC	19.01	21945579
63	Phosphorylation	SGSYLTLSQPVPAKR CCCEEEECCCCCCCC	27.48	21945579
69	Acetylation	LSQPVPAKRSPSPLG ECCCCCCCCCCCCCC	47.54	26051181
71	Phosphorylation	QPVPAKRSPSPLGTS CCCCCCCCCCCCCCC	29.08	30266825
71 (in isoform 2)	Phosphorylation	-	29.08	-
73	Phosphorylation	VPAKRSPSPLGTSVR CCCCCCCCCCCCCCC	33.72	30266825
73 (in isoform 2)	Phosphorylation	-	33.72	-
77	Phosphorylation	RSPSPLGTSVRSSPS CCCCCCCCCCCCCCC	31.56	29255136
78	Phosphorylation	SPSPLGTSVRSSPSL CCCCCCCCCCCCCCH	17.46	23663014
81	Phosphorylation	PLGTSVRSSPSLAKI CCCCCCCCCCCHHHC	44.43	22199227
82	Phosphorylation	LGTSVRSSPSLAKIQ CCCCCCCCCCHHHCC	14.14	22199227
84	Phosphorylation	TSVRSSPSLAKIQGS CCCCCCCCHHHCCCC	42.79	30576142
87	Ubiquitination	RSSPSLAKIQGSKQF CCCCCHHHCCCCCCE	40.64	29967540
92	Ubiquitination	LAKIQGSKQFSYDGT HHHCCCCCCEECCCC	63.29	29967540
95	Phosphorylation	IQGSKQFSYDGTDKN CCCCCCEECCCCCCC	21.59	21815630
96	Phosphorylation	QGSKQFSYDGTDKNI CCCCCEECCCCCCCC	21.49	23090842
99	Phosphorylation	KQFSYDGTDKNIPMK CCEECCCCCCCCCCC	40.68	23090842
109	Phosphorylation	NIPMKPPTPLLNTTS CCCCCCCCCCCCCCC	34.79	22199227
114	Phosphorylation	PPTPLLNTTSSLSGY CCCCCCCCCCCCCCC	28.20	22199227
114	Ubiquitination	PPTPLLNTTSSLSGY CCCCCCCCCCCCCCC	28.20	29967540
115	Phosphorylation	PTPLLNTTSSLSGYP CCCCCCCCCCCCCCC	18.42	28555341
116	Phosphorylation	TPLLNTTSSLSGYPL CCCCCCCCCCCCCCC	27.52	28348404
117	Phosphorylation	PLLNTTSSLSGYPLG CCCCCCCCCCCCCCC	25.18	28348404
119	Ubiquitination	LNTTSSLSGYPLGRA CCCCCCCCCCCCCCC	37.92	29967540
131	Phosphorylation	GRADFDHYTGRDSER CCCCCCCCCCCCHHH	16.85	25394399
131 (in isoform 2)	Phosphorylation	-	16.85	-
132	Phosphorylation	RADFDHYTGRDSERA CCCCCCCCCCCHHHH	23.48	-
136	Phosphorylation	DHYTGRDSERALRLS CCCCCCCHHHHHHHC	27.85	28555341
143	Phosphorylation	SERALRLSEKPPYSK HHHHHHHCCCCCCCC	36.82	28857561
148	Phosphorylation	RLSEKPPYSKYSSRH HHCCCCCCCCCCCCC	26.73	28674419
149	Phosphorylation	LSEKPPYSKYSSRHK HCCCCCCCCCCCCCC	30.78	-
157	Phosphorylation	KYSSRHKSHDNVYSL CCCCCCCCCCCCCCC	29.92	21945579
157 (in isoform 2)	Phosphorylation	-	29.92	-
162	Phosphorylation	HKSHDNVYSLGGLEG CCCCCCCCCCCCCCC	12.39	21945579
162 (in isoform 2)	Phosphorylation	-	12.39	-
163	Phosphorylation	KSHDNVYSLGGLEGR CCCCCCCCCCCCCCC	19.09	21945579
173	Phosphorylation	GLEGRKASGSLLAMW CCCCCCCCCCEEEEE	31.76	22199227
175	Phosphorylation	EGRKASGSLLAMWNG CCCCCCCCEEEEECC	20.09	22199227
183	Phosphorylation	LLAMWNGSSLSDAGP EEEEECCCCHHHCCC	25.54	22199227
184	Phosphorylation	LAMWNGSSLSDAGPP EEEECCCCHHHCCCC	33.04	22199227
186	Phosphorylation	MWNGSSLSDAGPPPI EECCCCHHHCCCCCC	27.62	29514088
194	Phosphorylation	DAGPPPISRSGAASM HCCCCCCCCCCCCCC	26.60	29514088
196	Phosphorylation	GPPPISRSGAASMPS CCCCCCCCCCCCCCC	26.45	23403867
200	Phosphorylation	ISRSGAASMPSSPKQ CCCCCCCCCCCCHHH	30.60	26846344
203	Phosphorylation	SGAASMPSSPKQARK CCCCCCCCCHHHHHC	51.10	30266825
204	Phosphorylation	GAASMPSSPKQARKM CCCCCCCCHHHHHCC	30.19	30266825
206	Acetylation	ASMPSSPKQARKMSI CCCCCCHHHHHCCCH	59.54	7973199
212	Phosphorylation	PKQARKMSIQDSLAL HHHHHCCCHHHHHHC	21.82	23927012
212 (in isoform 2)	Phosphorylation	-	21.82	-
216	Phosphorylation	RKMSIQDSLALQPKL HCCCHHHHHHCCHHH	10.12	23927012
224	Phosphorylation	LALQPKLTRHKELAS HHCCHHHHHHHHHHH	36.53	28555341
227	Ubiquitination	QPKLTRHKELASENI CHHHHHHHHHHHCCC	51.65	29967540
231	Phosphorylation	TRHKELASENINLRT HHHHHHHHCCCCCCC	43.74	23403867
240	Methylation	NINLRTRKYSSSSLS CCCCCCCCCCCCCHH	49.20	115974961
241	Phosphorylation	INLRTRKYSSSSLSH CCCCCCCCCCCCHHH	15.53	21945579
241 (in isoform 2)	Phosphorylation	-	15.53	-
242	Phosphorylation	NLRTRKYSSSSLSHM CCCCCCCCCCCHHHH	27.12	21945579
242 (in isoform 2)	Phosphorylation	-	27.12	-
243	Phosphorylation	LRTRKYSSSSLSHMG CCCCCCCCCCHHHHH	22.36	21945579
243 (in isoform 2)	Phosphorylation	-	22.36	-
244	Phosphorylation	RTRKYSSSSLSHMGA CCCCCCCCCHHHHHH	29.38	21945579
244 (in isoform 2)	Phosphorylation	-	29.38	-
245	Phosphorylation	TRKYSSSSLSHMGAY CCCCCCCCHHHHHHH	35.52	21945579
245 (in isoform 2)	Phosphorylation	-	35.52	-
247	Phosphorylation	KYSSSSLSHMGAYSR CCCCCCHHHHHHHHC	17.24	21945579
252	Phosphorylation	SLSHMGAYSRSLPRL CHHHHHHHHCCHHHH	10.01	21945579
252 (in isoform 2)	Phosphorylation	-	10.01	-
253	Phosphorylation	LSHMGAYSRSLPRLY HHHHHHHHCCHHHHH	18.17	21945579
254	Ubiquitination	SHMGAYSRSLPRLYR HHHHHHHCCHHHHHH	29.54	29967540
255	Phosphorylation	HMGAYSRSLPRLYRA HHHHHHCCHHHHHHC	36.46	20068231
263	Phosphorylation	LPRLYRATENQLTPL HHHHHHCCCCCCCCC	26.86	22199227
268	Phosphorylation	RATENQLTPLSLPPR HCCCCCCCCCCCCCC	16.66	22199227
271	Phosphorylation	ENQLTPLSLPPRNSL CCCCCCCCCCCCCCC	39.78	24719451
277	Phosphorylation	LSLPPRNSLGNSKRT CCCCCCCCCCCCCCC	38.64	22199227
281	Phosphorylation	PRNSLGNSKRTKLGE CCCCCCCCCCCCCCC	23.01	22199227
284	Phosphorylation	SLGNSKRTKLGEKDL CCCCCCCCCCCCCCC	34.06	-
285	Acetylation	LGNSKRTKLGEKDLP CCCCCCCCCCCCCCC	59.53	20167786
294	Phosphorylation	GEKDLPHSVIDNDNY CCCCCCCCCCCCCCC	20.87	26356563
301	Phosphorylation	SVIDNDNYLNFSSLS CCCCCCCCCCHHHCC	13.09	27273156
305	Phosphorylation	NDNYLNFSSLSSGAL CCCCCCHHHCCCCCC	29.33	22199227
306	Phosphorylation	DNYLNFSSLSSGALP CCCCCHHHCCCCCCC	28.29	22199227
308	Phosphorylation	YLNFSSLSSGALPYK CCCHHHCCCCCCCCC	28.77	25159151
308 (in isoform 2)	Phosphorylation	-	28.77	-
309	Phosphorylation	LNFSSLSSGALPYKT CCHHHCCCCCCCCCC	33.12	22199227
309 (in isoform 2)	Phosphorylation	-	33.12	-
314	Phosphorylation	LSSGALPYKTSASEG CCCCCCCCCCCCCCC	27.96	26356563
316	Phosphorylation	SGALPYKTSASEGNP CCCCCCCCCCCCCCC	24.55	23403867
317	Phosphorylation	GALPYKTSASEGNPY CCCCCCCCCCCCCCE	26.16	23403867
319	Phosphorylation	LPYKTSASEGNPYVS CCCCCCCCCCCCEEC	45.89	23403867
324	Phosphorylation	SASEGNPYVSSTLSV CCCCCCCEECEEECC	19.57	23927012
326	Phosphorylation	SEGNPYVSSTLSVPA CCCCCEECEEECCCC	16.26	23927012
327	Phosphorylation	EGNPYVSSTLSVPAS CCCCEECEEECCCCC	24.27	25159151
328	Phosphorylation	GNPYVSSTLSVPASP CCCEECEEECCCCCH	18.62	25159151
330	Phosphorylation	PYVSSTLSVPASPRV CEECEEECCCCCHHH	26.58	25159151
334	Phosphorylation	STLSVPASPRVARKM EEECCCCCHHHHHHH	13.73	20201521
334 (in isoform 2)	Phosphorylation	-	13.73	-
345	Phosphorylation	ARKMLLASTSSCASD HHHHHHHCCCCCCCC	28.88	27251275
346	Phosphorylation	RKMLLASTSSCASDD HHHHHHCCCCCCCCC	21.03	27251789
347	Phosphorylation	KMLLASTSSCASDDF HHHHHCCCCCCCCCC	22.41	29116813
347 (in isoform 2)	Phosphorylation	-	22.41	-
348	Phosphorylation	MLLASTSSCASDDFD HHHHCCCCCCCCCCC	17.50	27251789
348 (in isoform 2)	Phosphorylation	-	17.50	-
351	Phosphorylation	ASTSSCASDDFDQAS HCCCCCCCCCCCCHH	41.88	29507054
351 (in isoform 2)	Phosphorylation	-	41.88	-
358	Phosphorylation	SDDFDQASYVGTNPS CCCCCCHHCCCCCCC	18.08	27251275
359	Phosphorylation	DDFDQASYVGTNPSH CCCCCHHCCCCCCCC	13.10	27251275
361	Phosphorylation	FDQASYVGTNPSHSL CCCHHCCCCCCCCCC	16.13	32142685
362	Phosphorylation	DQASYVGTNPSHSLL CCHHCCCCCCCCCCC	33.63	24144214
365	Phosphorylation	SYVGTNPSHSLLAGE HCCCCCCCCCCCCCC	27.98	22210691
367	Phosphorylation	VGTNPSHSLLAGESD CCCCCCCCCCCCCCC	29.43	24144214
373	Phosphorylation	HSLLAGESDRVFATR CCCCCCCCCCEEEEC	29.78	24144214
384	Phosphorylation	FATRRNFSCGSVEFD EEECCCCCCCCEECC	22.55	30266825
384 (in isoform 2)	Phosphorylation	-	22.55	-
387	Phosphorylation	RRNFSCGSVEFDEAD CCCCCCCCEECCHHH	23.85	30266825
387 (in isoform 2)	Phosphorylation	-	23.85	-
397	Phosphorylation	FDEADLESLRQASGT CCHHHHHHHHHHCCC	35.83	30266825
402	Phosphorylation	LESLRQASGTPQPAL HHHHHHHCCCCCHHH	34.56	30266825
404	Phosphorylation	SLRQASGTPQPALRE HHHHHCCCCCHHHHH	19.09	30266825
404 (in isoform 2)	Phosphorylation	-	19.09	-
414	Phosphorylation	PALRERKSSISSISG HHHHHCHHHHHHCCC	38.84	23927012
414 (in isoform 2)	Phosphorylation	-	38.84	-
415	Phosphorylation	ALRERKSSISSISGR HHHHCHHHHHHCCCH	29.53	23927012
415 (in isoform 2)	Phosphorylation	-	29.53	-
417	Phosphorylation	RERKSSISSISGRDD HHCHHHHHHCCCHHH	24.46	30266825
417 (in isoform 2)	Phosphorylation	-	24.46	-
418	Phosphorylation	ERKSSISSISGRDDL HCHHHHHHCCCHHHH	21.07	30266825
420	Phosphorylation	KSSISSISGRDDLMD HHHHHHCCCHHHHHH	29.71	30266825
428	Phosphorylation	GRDDLMDYHRRQREE CHHHHHHHHHHHHHH	5.35	23403867
445	Phosphorylation	REQEMERLERQRLET HHHHHHHHHHHHHHH	3.97	33259812
455	Phosphorylation	QRLETILSLCAEYTK HHHHHHHHHHHHHCC	19.97	-
465	Phosphorylation	AEYTKPDSRLSTGTT HHHCCCCCCCCCCCC	43.58	20068231
465 (in isoform 2)	Phosphorylation	-	43.58	-
468	Phosphorylation	TKPDSRLSTGTTVED CCCCCCCCCCCCHHH	24.55	29255136
468 (in isoform 2)	Phosphorylation	-	24.55	-
469	Phosphorylation	KPDSRLSTGTTVEDV CCCCCCCCCCCHHHH	43.04	30266825
471	Phosphorylation	DSRLSTGTTVEDVQK CCCCCCCCCHHHHHH	27.97	30266825
472	Phosphorylation	SRLSTGTTVEDVQKI CCCCCCCCHHHHHHH	24.20	30266825
478	Ubiquitination	TTVEDVQKINKELEK CCHHHHHHHHHHHHH	48.36	29967540
489	Phosphorylation	ELEKLQLSDEESVFE HHHHCCCCCHHHHHH	29.98	29255136
489 (in isoform 2)	Phosphorylation	-	29.98	-
493	Phosphorylation	LQLSDEESVFEEALM CCCCCHHHHHHHHHC	30.02	30266825
493 (in isoform 2)	Phosphorylation	-	30.02	-
501	Phosphorylation	VFEEALMSPDTRYRC HHHHHHCCCCCCCCC	22.07	26055452
501 (in isoform 2)	Phosphorylation	-	22.07	-
504	Phosphorylation	EALMSPDTRYRCHRK HHHCCCCCCCCCCCC	32.74	23403867
504 (in isoform 2)	Phosphorylation	-	32.74	-
505	Ubiquitination	ALMSPDTRYRCHRKD HHCCCCCCCCCCCCC	25.03	29967540
506	Phosphorylation	LMSPDTRYRCHRKDS HCCCCCCCCCCCCCC	21.49	23090842
511	Acetylation	TRYRCHRKDSLPDAD CCCCCCCCCCCCCCC	28.18	26051181
513	Phosphorylation	YRCHRKDSLPDADLA CCCCCCCCCCCCCHH	44.85	29255136
513 (in isoform 2)	Phosphorylation	-	44.85	-
516	Phosphorylation	HRKDSLPDADLASCG CCCCCCCCCCHHHCC	58.99	32142685
521	Phosphorylation	LPDADLASCGSLSQS CCCCCHHHCCCCCCC	26.72	23927012
521 (in isoform 2)	Phosphorylation	-	26.72	-
524	Phosphorylation	ADLASCGSLSQSSAS CCHHHCCCCCCCCCC	29.22	23927012
524 (in isoform 2)	Phosphorylation	-	29.22	-
526	Phosphorylation	LASCGSLSQSSASFF HHHCCCCCCCCCCCC	29.70	23927012
526 (in isoform 2)	Phosphorylation	-	29.70	-
528	Phosphorylation	SCGSLSQSSASFFTP HCCCCCCCCCCCCCC	25.21	29743597
529	Phosphorylation	CGSLSQSSASFFTPR CCCCCCCCCCCCCCC	21.94	23403867
531	Phosphorylation	SLSQSSASFFTPRST CCCCCCCCCCCCCCC	23.88	23403867
534	Phosphorylation	QSSASFFTPRSTRND CCCCCCCCCCCCCCH	18.78	23403867
537	Phosphorylation	ASFFTPRSTRNDELL CCCCCCCCCCCHHHH	32.68	22210691
538	Phosphorylation	SFFTPRSTRNDELLS CCCCCCCCCCHHHHH	34.47	22210691
540	Phosphorylation	FTPRSTRNDELLSDL CCCCCCCCHHHHHHH	47.39	32142685
545	Phosphorylation	TRNDELLSDLTRTPP CCCHHHHHHHHCCCC	43.10	28176443
548	Phosphorylation	DELLSDLTRTPPPPS HHHHHHHHCCCCCCC	37.17	25159151
550	Phosphorylation	LLSDLTRTPPPPSST HHHHHHCCCCCCCCC	34.61	30266825
550 (in isoform 2)	Phosphorylation	-	34.61	-
555	Phosphorylation	TRTPPPPSSTFPKAS HCCCCCCCCCCCCCC	48.02	24732914
556	Phosphorylation	RTPPPPSSTFPKASS CCCCCCCCCCCCCCC	39.58	24732914
557	O-linked_Glycosylation	TPPPPSSTFPKASSE CCCCCCCCCCCCCCC	48.58	30379171
557	Phosphorylation	TPPPPSSTFPKASSE CCCCCCCCCCCCCCC	48.58	24732914
562	Phosphorylation	SSTFPKASSESSYLS CCCCCCCCCCCCCCC	40.54	21945579
563	Phosphorylation	STFPKASSESSYLSI CCCCCCCCCCCCCCC	46.48	21945579
565	Phosphorylation	FPKASSESSYLSILP CCCCCCCCCCCCCCC	26.65	21945579
565 (in isoform 2)	Phosphorylation	-	26.65	-
566	Phosphorylation	PKASSESSYLSILPK CCCCCCCCCCCCCCC	26.49	21945579
567	Phosphorylation	KASSESSYLSILPKT CCCCCCCCCCCCCCC	17.47	21945579
569	Phosphorylation	SSESSYLSILPKTPE CCCCCCCCCCCCCCC	17.53	21945579
574	Phosphorylation	YLSILPKTPEGISEE CCCCCCCCCCCCCHH	25.32	30266825
574 (in isoform 2)	Phosphorylation	-	25.32	-
577	Phosphorylation	ILPKTPEGISEEQRS CCCCCCCCCCHHHHH	29.90	32645325
579	Phosphorylation	PKTPEGISEEQRSQE CCCCCCCCHHHHHHH	46.03	30266825
618	Phosphorylation	INDQMDESFRELDME HHHHHCHHHHHHHHH	25.91	21815630
644	Malonylation	TTELMKEKEILDHLN HHHHHHHHHHHHHHH	44.53	32601280
659	Ubiquitination	RKIAELEKNIVGEKT HHHHHHHHHHCCHHH	65.68	29967540
665	Acetylation	EKNIVGEKTKEKVKL HHHHCCHHHHHHHHH	59.99	24431397
666	Phosphorylation	KNIVGEKTKEKVKLD HHHCCHHHHHHHHHH	39.88	-
667	Acetylation	NIVGEKTKEKVKLDA HHCCHHHHHHHHHHH	67.61	24431407
686	Phosphorylation	LERLQELYSEQKTQL HHHHHHHHHHHHHHH	14.92	21945579
699	Phosphorylation	QLDNCPESMREQLQQ HHHCCCHHHHHHHHH	14.31	28555341
719	Phosphorylation	ADLLDVESKHFEDLE HHHHCHHHHHHHHHH	31.14	29514088
727	Ubiquitination	KHFEDLEFQQLEHES HHHHHHHHHHHHHHH	7.93	29967540
745	Ubiquitination	EEKENLTQQLLREVA HHHHHHHHHHHHHHH	34.78	27667366
754	Ubiquitination	LLREVAEYQRNIVSR HHHHHHHHHHHHCCH	11.75	29967540
767	Ubiquitination	SRKEKISALKKQANH CHHHHHHHHHHHHHH	27.20	33845483
770	Ubiquitination	EKISALKKQANHIVQ HHHHHHHHHHHHHHH	56.33	29967540
772	Ubiquitination	ISALKKQANHIVQQA HHHHHHHHHHHHHHH	20.60	27667366
775	Ubiquitination	LKKQANHIVQQAQRE HHHHHHHHHHHHHHH	2.76	23000965
788	Ubiquitination	REQDHFVKEKNNLIM HHHHHHHHHHHHHHH	63.13	27667366
794	Ubiquitination	VKEKNNLIMMLQREK HHHHHHHHHHHHHHH	1.33	33845483
802	Ubiquitination	MMLQREKENLCNLEK HHHHHHHHHHHCHHH	51.16	23000965
810	Ubiquitination	NLCNLEKKYSSLSGG HHHCHHHHHHHCCCC	40.78	33845483
811	Phosphorylation	LCNLEKKYSSLSGGK HHCHHHHHHHCCCCC	17.98	-
812	Phosphorylation	CNLEKKYSSLSGGKG HCHHHHHHHCCCCCC	33.41	-
813	Phosphorylation	NLEKKYSSLSGGKGF CHHHHHHHCCCCCCC	24.38	24275569
815	Phosphorylation	EKKYSSLSGGKGFPV HHHHHHCCCCCCCCC	47.66	28674419
818	Ubiquitination	YSSLSGGKGFPVNPN HHHCCCCCCCCCCCC	61.99	23000965
844	Phosphorylation	INEPCGNSTNLSPST CCCCCCCCCCCCCCC	12.17	28348404
845	Phosphorylation	NEPCGNSTNLSPSTQ CCCCCCCCCCCCCCC	44.15	28348404
848	Phosphorylation	CGNSTNLSPSTQFPA CCCCCCCCCCCCCCC	20.90	28348404
850	Phosphorylation	NSTNLSPSTQFPADA CCCCCCCCCCCCCCC	31.31	28348404
851	Phosphorylation	STNLSPSTQFPADAD CCCCCCCCCCCCCCC	37.30	28348404
855 (in isoform 2)	Phosphorylation	-	26.38	-
862	Phosphorylation	ADADAVATEPATAVL CCCCCCCCCCCHHHH	35.58	28348404
866 (in isoform 2)	Phosphorylation	-	28.19	-
881	Phosphorylation	QSKEHFRSLEERKKQ CCHHHHHCHHHHHHH	38.91	28555341
894	Phosphorylation	KQHKEGLYLSDTLPR HHHHCCCCCCCCCCC	18.28	21945579
896	Phosphorylation	HKEGLYLSDTLPRKK HHCCCCCCCCCCCCC	18.26	21945579
898	Phosphorylation	EGLYLSDTLPRKKTT CCCCCCCCCCCCCCC	34.97	19664994
904	Phosphorylation	DTLPRKKTTSSISPH CCCCCCCCCCCCCCC	34.64	23403867
905	Phosphorylation	TLPRKKTTSSISPHF CCCCCCCCCCCCCCC	29.38	23403867
906	Phosphorylation	LPRKKTTSSISPHFS CCCCCCCCCCCCCCC	30.79	23403867
907	Phosphorylation	PRKKTTSSISPHFSS CCCCCCCCCCCCCCC	25.62	23403867
909	Phosphorylation	KKTTSSISPHFSSAT CCCCCCCCCCCCCCC	17.80	25159151
913	Phosphorylation	SSISPHFSSATMGRS CCCCCCCCCCCCCCC	18.94	23403867
914	Phosphorylation	SISPHFSSATMGRSI CCCCCCCCCCCCCCC	27.15	23403867
916	Phosphorylation	SPHFSSATMGRSITP CCCCCCCCCCCCCCC	23.31	23403867
932	Phosphorylation	AHLPLGQSNSCGSVL CCCCCCCCCCCCCCC	28.98	23927012
934	Phosphorylation	LPLGQSNSCGSVLPP CCCCCCCCCCCCCCH	25.71	23927012
937	Phosphorylation	GQSNSCGSVLPPSLA CCCCCCCCCCCHHHH	25.47	23927012
942	Phosphorylation	CGSVLPPSLAAMAKD CCCCCCHHHHHHHCC	28.80	23403867
964	Phosphorylation	RGYNHQQMSEGHRQK HCCCHHHCCHHHHCH	2.95	32142685
975	Phosphorylation	HRQKSEFYNRTASES HHCHHHHHHCCCCCC	10.32	30576142
978	Phosphorylation	KSEFYNRTASESNVY HHHHHHCCCCCCCEE	30.78	26657352
980	Phosphorylation	EFYNRTASESNVYLN HHHHCCCCCCCEEEC	40.73	25159151
982	Phosphorylation	YNRTASESNVYLNSF HHCCCCCCCEEECCC	29.15	23927012
985	Phosphorylation	TASESNVYLNSFHYP CCCCCCEEECCCCCC	12.38	23403867
988	Phosphorylation	ESNVYLNSFHYPDHS CCCEEECCCCCCCCC	15.71	23403867
991	Phosphorylation	VYLNSFHYPDHSYKD EEECCCCCCCCCCCC	14.35	23403867
995	Phosphorylation	SFHYPDHSYKDQAFD CCCCCCCCCCCCCCE	41.06	23403867
996	Phosphorylation	FHYPDHSYKDQAFDT CCCCCCCCCCCCCEE	18.37	23403867
1009	Phosphorylation	DTLSLDSSDSMETSI EEEECCCCCCCCCHH	33.11	21601212
1014	Phosphorylation	DSSDSMETSISACSP CCCCCCCCHHHHCCC	23.79	30576142
1020	Phosphorylation	ETSISACSPDNISSA CCHHHHCCCCCCCCC	34.70	24275569
1029	Phosphorylation	DNISSASTSNIARIE CCCCCCCCHHHHHHH	26.05	30576142
1030	Phosphorylation	NISSASTSNIARIEE CCCCCCCHHHHHHHH	24.60	30576142
1047	Ubiquitination	RLLKQAHAEKTRLLE HHHHHHHHHHHHHHH	24.01	29967540
1055	Phosphorylation	EKTRLLESREREMEA HHHHHHHHHHHHHHH	39.14	25954137
1063	Acetylation	REREMEAKKRALEEE HHHHHHHHHHHHHHH	29.50	12649961
1074	Ubiquitination	LEEEKRRREILEKRL HHHHHHHHHHHHHHH	39.06	29967540
1090	Ubiquitination	EETSQRQKLIEKEVK HHHHHHHHHHHHHHH	54.33	29967540
1110	Phosphorylation	RAQARPLTRYLPVRK HHHHCCCHHHCCCCH	21.68	23403867
1112	Phosphorylation	QARPLTRYLPVRKED HHCCCHHHCCCCHHH	15.32	23403867
1128	Phosphorylation	DLRSHVETAGHNIDT CHHHHHHHCCCCCCC	36.53	-
1140	Phosphorylation	IDTCYHVSITEKTCR CCCEEEEEECCCHHH	15.52	28060719
1156	Ubiquitination	FLIKMGGKIKTWKKR EEEECCCEECEEEEE	34.99	-
1208	Phosphorylation	HLKNANKSPNPLLTF HHHHCCCCCCCCEEE	29.71	23285258

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of PHLB2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PHLB2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PHLB2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FLNC_HUMAN	FLNC	physical	12376540
UBP7_HUMAN	USP7	physical	21988832
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
DEN1A_HUMAN	DENND1A	physical	27173435
SPD2A_HUMAN	SH3PXD2A	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
RTKN_HUMAN	RTKN	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
CING_HUMAN	CGN	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
PPM1H_HUMAN	PPM1H	physical	27173435
ZN638_HUMAN	ZNF638	physical	27173435
DEN4C_HUMAN	DENND4C	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
MPIP2_HUMAN	CDC25B	physical	27173435
CDK16_HUMAN	CDK16	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
SIN1_HUMAN	MAPKAP1	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
NF1_HUMAN	NF1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
TIAM1_HUMAN	TIAM1	physical	27173435
MPIP3_HUMAN	CDC25C	physical	27173435
M3K21_HUMAN	KIAA1804	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
CAMP2_HUMAN	CAMSAP2	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435
RAB3I_HUMAN	RAB3IP	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PHLB2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-157, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-334, AND MASSSPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-71; SER-73; SER-157;SER-212; SER-334; SER-384; SER-387; SER-415; SER-417; SER-468;SER-489; SER-501; SER-513; THR-550; THR-574 AND THR-898, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-909, AND MASSSPECTROMETRY.	18220336 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-468, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489, AND MASSSPECTROMETRY.	15302935 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-404, AND MASSSPECTROMETRY.	16964243 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-324; TYR-567 ANDTYR-894, AND MASS SPECTROMETRY.	19534553 [Abstract]