M3K21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: M3K21_HUMAN
• UniProt AC: Q5TCX8
• Protein Name: Mitogen-activated protein kinase kinase kinase 21
• Gene Name: MAP3K21 {ECO:0000312|HGNC:HGNC:29798}
• Organism: Homo sapiens (Human).
• Sequence Length: 1036
• Protein Description: Negative regulator of TLR4 signaling. Does not activate JNK1/MAPK8 pathway, p38/MAPK14, nor ERK2/MAPK1 pathways..
• Protein Sequence: MALRGAAGATDTPVSSAGGAPGGSASSSSTSSGGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPANYVAPCRPAASPAPPPSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQGQEVAVKAARQDPEQDAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTKMSTAGTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWQQDPHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPKVKKRKGKFKRSRLKLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQLTSDESNKTWGRNTVFRQEEFEDVKRNFKKKGCTWGPNSIQMKDRTDCKERIRPLSDGNSPWSTILIKNQKTMPLASLFVDQPGSCEEPKLSPDGLEHRKPKQIKLPSQAYIDLPLGKDAQRENPAEAESWEEAASANAATVSIEMTPTNSLSRSPQRKKTESALYGCTVLLASVALGLDLRELHKAQAAEEPLPKEEKKKREGIFQRASKSRRSASPPTSLPSTCGEASSPPSLPLSSALGILSTPSFSTKCLLQMDSEDPLVDSAPVTCDSEMLTPDFCPTAPGSGREPALMPRLDTDCSVSRNLPSSFLQQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTGATIISATGASALPLCPSPAPHSHLPREVSPKKHSTVHIVPQRRPASLRSRSDLPQAYPQTAVSQLAQTACVVGRPGPHPTQFLAAKERTKSHVPSLLDADVEGQSRDYTVPLCRMRSKTSRPSIYELEKEFLS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	LRGAAGATDTPVSSA CCCCCCCCCCCCCCC		30631047
47	Phosphorylation	AGLWAALYDYEARGE HHHHHHHHCHHHCCC		25884760
58	Phosphorylation	ARGEDELSLRRGQLV HCCCCHHHCCCCCEE		24719451
96	Phosphorylation	LGIFPANYVAPCRPA HCCCCCCCCEECCCC		-
105	Phosphorylation	APCRPAASPAPPPSR EECCCCCCCCCCCCC		28152594
111	Phosphorylation	ASPAPPPSRPSSPVH CCCCCCCCCCCCCCE		28152594
114	Phosphorylation	APPPSRPSSPVHVAF CCCCCCCCCCCEEEE		21082442
115	Phosphorylation	PPPSRPSSPVHVAFE CCCCCCCCCCEEEEE		28152594
142	Phosphorylation	FGQVYRATWQGQEVA CCHHHHEEECCCHHH		-
286	Ubiquitination	DICNKTLKITDFGLA CCCCCCEEECCHHHH		-
299	Phosphorylation	LAREWHRTTKMSTAG HHHHHHCCCCCCCCC		-
303	Phosphorylation	WHRTTKMSTAGTYAW HHCCCCCCCCCCHHH		25072903
304	Phosphorylation	HRTTKMSTAGTYAWM HCCCCCCCCCCHHHH		25072903
307	Phosphorylation	TKMSTAGTYAWMAPE CCCCCCCCHHHHCHH		25072903
308	Phosphorylation	KMSTAGTYAWMAPEV CCCCCCCHHHHCHHH		25072903
322	Phosphorylation	VIKSSLFSKGSDIWS HHHHHHHCCCCCHHH		24719451
339	Phosphorylation	VLLWELLTGEVPYRG HHHHHHHHCCCCCCC		28450419
341	Phosphorylation	LWELLTGEVPYRGID HHHHHHCCCCCCCCC		28450419
346	Phosphorylation	TGEVPYRGIDGLAVA HCCCCCCCCCHHHHH		28450419
348	Phosphorylation	EVPYRGIDGLAVAYG CCCCCCCCHHHHHCE		28450419
351	Phosphorylation	YRGIDGLAVAYGVAV CCCCCHHHHHCEEEE		28450419
354	Phosphorylation	IDGLAVAYGVAVNKL CCHHHHHCEEEECEE		27251275
356	Phosphorylation	GLAVAYGVAVNKLTL HHHHHCEEEECEECC		23927012
359	Phosphorylation	VAYGVAVNKLTLPIP HHCEEEECEECCCCC		27251275
366	Phosphorylation	NKLTLPIPSTCPEPF CEECCCCCCCCCHHH		23927012
371	Phosphorylation	PIPSTCPEPFAKLMK CCCCCCCHHHHHHHH		29449344
454	Ubiquitination	TRAALQQKSQEELLK HHHHHHHHHHHHHHH		29967540
455	Phosphorylation	RAALQQKSQEELLKR HHHHHHHHHHHHHHH		30266825
514	Phosphorylation	LKDGHRISLPSDFQH CCCCCCCCCCCCCCC		30266825
517	Phosphorylation	GHRISLPSDFQHKIT CCCCCCCCCCCCEEE		30266825
524	Phosphorylation	SDFQHKITVQASPNL CCCCCEEEEEECCCC		30266825
528	Phosphorylation	HKITVQASPNLDKRR CEEEEEECCCCCCCC		19664994
536	Phosphorylation	PNLDKRRSLNSSSSS CCCCCCCCCCCCCCC		23927012
539	Phosphorylation	DKRRSLNSSSSSPPS CCCCCCCCCCCCCCC		30576142
540	Phosphorylation	KRRSLNSSSSSPPSS CCCCCCCCCCCCCCC		30576142
541	Phosphorylation	RRSLNSSSSSPPSSP CCCCCCCCCCCCCCC		30576142
542	Phosphorylation	RSLNSSSSSPPSSPT CCCCCCCCCCCCCCC		30576142
543	Phosphorylation	SLNSSSSSPPSSPTM CCCCCCCCCCCCCCC		23927012
546	Phosphorylation	SSSSSPPSSPTMMPR CCCCCCCCCCCCHHH		23927012
547	Phosphorylation	SSSSPPSSPTMMPRL CCCCCCCCCCCHHHE		30576142
549	Phosphorylation	SSPPSSPTMMPRLRA CCCCCCCCCHHHEEE		23927012
560	Phosphorylation	RLRAIQLTSDESNKT HEEEEECCCCCCCCC		23312004
561	Phosphorylation	LRAIQLTSDESNKTW EEEEECCCCCCCCCC		21815630
562 (in isoform 2)	Phosphorylation	-		19276368
564	Phosphorylation	IQLTSDESNKTWGRN EECCCCCCCCCCCCC		23312004
567	Phosphorylation	TSDESNKTWGRNTVF CCCCCCCCCCCCCCC		23312004
572	Phosphorylation	NKTWGRNTVFRQEEF CCCCCCCCCCCHHHH		24719451
592	Phosphorylation	NFKKKGCTWGPNSIQ HHHHCCCCCCCCCCC		23927012
597	Phosphorylation	GCTWGPNSIQMKDRT CCCCCCCCCCCCCCC		23927012
604	Phosphorylation	SIQMKDRTDCKERIR CCCCCCCCCHHHHCC		-
614	Phosphorylation	KERIRPLSDGNSPWS HHHCCCCCCCCCCCC		23927012
618	Phosphorylation	RPLSDGNSPWSTILI CCCCCCCCCCCEEEE		23927012
621	Phosphorylation	SDGNSPWSTILIKNQ CCCCCCCCEEEEECC		28450419
622	Phosphorylation	DGNSPWSTILIKNQK CCCCCCCEEEEECCC		23927012
643	Phosphorylation	LFVDQPGSCEEPKLS EECCCCCCCCCCCCC		28857561
650	Phosphorylation	SCEEPKLSPDGLEHR CCCCCCCCCCCCCCC		25159151
666	Phosphorylation	PKQIKLPSQAYIDLP CCCCCCCCCEEEECC		28857561
669	Phosphorylation	IKLPSQAYIDLPLGK CCCCCCEEEECCCCC		28796482
719	Phosphorylation	RSPQRKKTESALYGC CCCCCHHHHHHHHHH		-
721	Phosphorylation	PQRKKTESALYGCTV CCCHHHHHHHHHHHH		24719451
724	Phosphorylation	KKTESALYGCTVLLA HHHHHHHHHHHHHHH		24719451
732	Phosphorylation	GCTVLLASVALGLDL HHHHHHHHHHHCCCH		24719451
768	Phosphorylation	EGIFQRASKSRRSAS HHHHHHHHHCCCCCC		24719451
773	Phosphorylation	RASKSRRSASPPTSL HHHHCCCCCCCCCCC		26657352
775	Phosphorylation	SKSRRSASPPTSLPS HHCCCCCCCCCCCCC		29802988
778	Phosphorylation	RRSASPPTSLPSTCG CCCCCCCCCCCCCCC		21130716
779	Phosphorylation	RSASPPTSLPSTCGE CCCCCCCCCCCCCCC		28464451
893	Phosphorylation	RPSHHRRTMSDGNPT CCCCCCCCCCCCCCC		23090842
893	Phosphorylation	RPSHHRRTMSDGNPT CCCCCCCCCCCCCCC		28450419
895	Phosphorylation	SHHRRTMSDGNPTPT CCCCCCCCCCCCCCC		-
895	Phosphorylation	SHHRRTMSDGNPTPT CCCCCCCCCCCCCCC		28450419
900	Phosphorylation	TMSDGNPTPTGATII CCCCCCCCCCCCEEE		28450419
902	Phosphorylation	SDGNPTPTGATIISA CCCCCCCCCCEEEEC		28450419
905	Phosphorylation	NPTPTGATIISATGA CCCCCCCEEEECCCC		28450419
908	Phosphorylation	PTGATIISATGASAL CCCCEEEECCCCCCC		27251275
910	Phosphorylation	GATIISATGASALPL CCEEEECCCCCCCCC		23927012
913	Phosphorylation	IISATGASALPLCPS EEECCCCCCCCCCCC		27251275
920	Phosphorylation	SALPLCPSPAPHSHL CCCCCCCCCCCCCCC		-
920	Phosphorylation	SALPLCPSPAPHSHL CCCCCCCCCCCCCCC		23927012
925	Phosphorylation	CPSPAPHSHLPREVS CCCCCCCCCCCCCCC		29449344
932	Phosphorylation	SHLPREVSPKKHSTV CCCCCCCCCCCCCCE		23312004
937	Phosphorylation	EVSPKKHSTVHIVPQ CCCCCCCCCEEECCC		23312004
938	Phosphorylation	VSPKKHSTVHIVPQR CCCCCCCCEEECCCC		23312004
949	Phosphorylation	VPQRRPASLRSRSDL CCCCCCCCCCCCCCC		27282143
1011	Phosphorylation	VEGQSRDYTVPLCRM CCCCCCCCCCCCCCC		28796482
1012	Phosphorylation	EGQSRDYTVPLCRMR CCCCCCCCCCCCCCC		28555341
1020	Phosphorylation	VPLCRMRSKTSRPSI CCCCCCCCCCCCCCH		29449344
1022	Phosphorylation	LCRMRSKTSRPSIYE CCCCCCCCCCCCHHH		29449344
1023	Phosphorylation	CRMRSKTSRPSIYEL CCCCCCCCCCCHHHH		29449344
1026	Phosphorylation	RSKTSRPSIYELEKE CCCCCCCCHHHHHHH		29978859
1028	Phosphorylation	KTSRPSIYELEKEFL CCCCCCHHHHHHHHC		29978859

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
303	S	Phosphorylation	Kinase	MAP4K1	Q92918	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of M3K21_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of M3K21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KCTD3_HUMAN	KCTD3	physical	27173435
KI13B_HUMAN	KIF13B	physical	27173435
ZBT21_HUMAN	ZBTB21	physical	27173435
GGYF1_HUMAN	GIGYF1	physical	27173435
LRFN1_HUMAN	LRFN1	physical	27173435
CING_HUMAN	CGN	physical	27173435
SRGP2_HUMAN	SRGAP2	physical	27173435
MAST3_HUMAN	MAST3	physical	27173435
SI1L1_HUMAN	SIPA1L1	physical	27173435
LIMA1_HUMAN	LIMA1	physical	27173435
MAGI1_HUMAN	MAGI1	physical	27173435
TESK2_HUMAN	TESK2	physical	27173435
DCLK1_HUMAN	DCLK1	physical	27173435
HDAC4_HUMAN	HDAC4	physical	27173435
SRS12_HUMAN	SRSF12	physical	27173435
SYDE1_HUMAN	SYDE1	physical	27173435
NF1_HUMAN	NF1	physical	27173435
AGAP1_HUMAN	AGAP1	physical	27173435
CBY1_HUMAN	CBY1	physical	27173435
NADK_HUMAN	NADK	physical	27173435
F110B_HUMAN	FAM110B	physical	27173435
UBP21_HUMAN	USP21	physical	27173435
GGYF2_HUMAN	GIGYF2	physical	27173435
AN34A_HUMAN	ANKRD34A	physical	27173435
FA53C_HUMAN	FAM53C	physical	27173435
TIAM1_HUMAN	TIAM1	physical	27173435
NGAP_HUMAN	RASAL2	physical	27173435
RGPS2_HUMAN	RALGPS2	physical	27173435
F110A_HUMAN	FAM110A	physical	27173435
PKHA7_HUMAN	PLEKHA7	physical	27173435
KIF1C_HUMAN	KIF1C	physical	27173435
INP5E_HUMAN	INPP5E	physical	27173435
CHIP_HUMAN	STUB1	physical	28757353

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.