| UniProt ID | UBP21_HUMAN | |
|---|---|---|
| UniProt AC | Q9UK80 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 21 | |
| Gene Name | USP21 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 565 | |
| Subcellular Localization | Cytoplasm . Nucleus . | |
| Protein Description | Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates. [PubMed: 10799498 Deubiquitinates BAZ2A/TIP5 leading to its stabilization] | |
| Protein Sequence | MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPDERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLRPMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASHGSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPVSENQVASSEGYVLFYQLMQEPPRCL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 25 | Phosphorylation | NIQPRVGSKLPFAPR CCCCCCCCCCCCCCC | 28.32 | 28674151 | |
| 93 | Phosphorylation | HGVPLPGSPPPTVAL CCCCCCCCCCCCEEE | 32.09 | 27794612 | |
| 97 | Phosphorylation | LPGSPPPTVALPLPS CCCCCCCCEEECCCC | 24.96 | 28450419 | |
| 97 | Ubiquitination | LPGSPPPTVALPLPS CCCCCCCCEEECCCC | 24.96 | 22817900 | |
| 98 | Ubiquitination | PGSPPPTVALPLPSR CCCCCCCEEECCCCC | 6.76 | 22817900 | |
| 104 | Ubiquitination | TVALPLPSRTNLARS CEEECCCCCCCHHHC | 60.46 | 22817900 | |
| 104 | Phosphorylation | TVALPLPSRTNLARS CEEECCCCCCCHHHC | 60.46 | 24117733 | |
| 106 | Phosphorylation | ALPLPSRTNLARSKS EECCCCCCCHHHCCC | 38.63 | - | |
| 111 | Phosphorylation | SRTNLARSKSVSSGD CCCCHHHCCCCCCCC | 24.55 | 29083192 | |
| 113 | Acetylation | TNLARSKSVSSGDLR CCHHHCCCCCCCCCC | 28.60 | 19413330 | |
| 113 | Phosphorylation | TNLARSKSVSSGDLR CCHHHCCCCCCCCCC | 28.60 | 30576142 | |
| 115 | Phosphorylation | LARSKSVSSGDLRPM HHHCCCCCCCCCCCC | 35.38 | 28450419 | |
| 116 | Phosphorylation | ARSKSVSSGDLRPMG HHCCCCCCCCCCCCE | 33.88 | 28450419 | |
| 132 | Phosphorylation | ALGGHRGTGELGAAL EECCCCCCHHHHHHH | 27.69 | 19413330 | |
| 140 | Phosphorylation | GELGAALSRLALRPE HHHHHHHHHHHHCCC | 22.11 | 19413330 | |
| 174 | Phosphorylation | PTLFSIRTEPPASHG CCEEEEECCCCCCCC | 51.69 | 27251275 | |
| 179 | Phosphorylation | IRTEPPASHGSFHMI EECCCCCCCCCEEEE | 33.87 | 27251275 | |
| 182 | Phosphorylation | EPPASHGSFHMISAR CCCCCCCCEEEEECC | 13.42 | 27251275 | |
| 204 | Phosphorylation | DDKMAHHTLLLGSGH CCCHHCEEEEECCCC | 14.83 | 22210691 | |
| 222 | Ubiquitination | RNLGNTCFLNAVLQC HHCCCCHHHHHHHHH | 5.77 | 22817900 | |
| 223 | Ubiquitination | NLGNTCFLNAVLQCL HCCCCHHHHHHHHHH | 4.35 | 22817900 | |
| 229 | Ubiquitination | FLNAVLQCLSSTRPL HHHHHHHHHHCCCCH | 3.30 | 22817900 | |
| 289 | Ubiquitination | RFRAVFQKYVPSFSG HHHHHHHHHCCCCCC | 36.43 | - | |
| 290 | Phosphorylation | FRAVFQKYVPSFSGY HHHHHHHHCCCCCCC | 13.55 | - | |
| 297 | Phosphorylation | YVPSFSGYSQQDAQE HCCCCCCCCHHHHHH | 11.34 | - | |
| 335 | Phosphorylation | LANGPVPSPPRRGGA CCCCCCCCCCCCCCC | 48.01 | 26091039 | |
| 362 | Phosphorylation | ANLMWKRYLEREDSK HHHHHHHHHHHCCCH | 14.80 | 26074081 | |
| 368 | Phosphorylation | RYLEREDSKIVDLFV HHHHHCCCHHHHHHH | 21.38 | 26074081 | |
| 379 | Ubiquitination | DLFVGQLKSCLKCQA HHHHHHHHHHHHCCC | 31.10 | - | |
| 389 | Phosphorylation | LKCQACGYRSTTFEV HHCCCCCCCCCEEEE | 10.98 | 30576142 | |
| 392 | Phosphorylation | QACGYRSTTFEVFCD CCCCCCCCEEEEEEE | 26.89 | 30576142 | |
| 393 | Phosphorylation | ACGYRSTTFEVFCDL CCCCCCCEEEEEEEE | 21.03 | 30576142 | |
| 406 | Ubiquitination | DLSLPIPKKGFAGGK EECCCCCCCCCCCCC | 67.27 | 22817900 | |
| 407 (in isoform 3) | Ubiquitination | - | 54.64 | 21906983 | |
| 407 (in isoform 1) | Ubiquitination | - | 54.64 | 21906983 | |
| 407 | Ubiquitination | LSLPIPKKGFAGGKV ECCCCCCCCCCCCCE | 54.64 | 21906983 | |
| 413 (in isoform 3) | Ubiquitination | - | 27.94 | 21906983 | |
| 413 (in isoform 1) | Ubiquitination | - | 27.94 | 21906983 | |
| 413 | Ubiquitination | KKGFAGGKVSLRDCF CCCCCCCCEEHHHHH | 27.94 | 22817900 | |
| 435 | Ubiquitination | ELESENAPVCDRCRQ HHHCCCCCCCHHHHH | 38.56 | 22817900 | |
| 436 | Ubiquitination | LESENAPVCDRCRQK HHCCCCCCCHHHHHH | 5.01 | 22817900 | |
| 442 | Ubiquitination | PVCDRCRQKTRSTKK CCCHHHHHHCCCCCC | 55.91 | 22817900 | |
| 451 | Phosphorylation | TRSTKKLTVQRFPRI CCCCCCCHHHHCCCE | 24.38 | 24719451 | |
| 475 | Ubiquitination | ASRGSIKKSSVGVDF CCCCCCCHHCCCCCC | 46.42 | 29967540 | |
| 499 | Phosphorylation | FASDKAGSPVYQLYA HCCCCCCCCHHHHHH | 18.95 | 24043423 | |
| 502 | Phosphorylation | DKAGSPVYQLYALCN CCCCCCHHHHHHHHC | 9.00 | 24043423 | |
| 504 | Ubiquitination | AGSPVYQLYALCNHS CCCCHHHHHHHHCCC | 1.16 | 29967540 | |
| 505 | Phosphorylation | GSPVYQLYALCNHSG CCCHHHHHHHHCCCC | 5.08 | 24043423 | |
| 511 | Phosphorylation | LYALCNHSGSVHYGH HHHHHCCCCCCEEEE | 20.83 | 24043423 | |
| 513 | Phosphorylation | ALCNHSGSVHYGHYT HHHCCCCCCEEEEEE | 14.56 | 24043423 | |
| 516 | Phosphorylation | NHSGSVHYGHYTALC CCCCCCEEEEEEEEE | 11.93 | 24043423 | |
| 519 | Phosphorylation | GSVHYGHYTALCRCQ CCCEEEEEEEEEECC | 6.85 | 24043423 | |
| 520 | Phosphorylation | SVHYGHYTALCRCQT CCEEEEEEEEEECCC | 13.89 | 24043423 | |
| 538 | Phosphorylation | VYNDSRVSPVSENQV EECCCCCCCCCHHHC | 20.62 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 538 | S | Phosphorylation | Kinase | MAPK14 | Q16539 | GPS |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP21_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP21_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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