ZN350_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN350_HUMAN
• UniProt AC: Q9GZX5
• Protein Name: Zinc finger protein 350
• Gene Name: ZNF350
• Organism: Homo sapiens (Human).
• Sequence Length: 532
• Subcellular Localization: Nucleus. Nucleus matrix. Associated with the nuclear matrix.
• Protein Description: Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3..
• Protein Sequence: MIQAQESITLEDVAVDFTWEEWQLLGAAQKDLYRDVMLENYSNLVAVGYQASKPDALFKLEQGEQLWTIEDGIHSGACSDIWKVDHVLERLQSESLVNRRKPCHEHDAFENIVHCSKSQFLLGQNHDIFDLRGKSLKSNLTLVNQSKGYEIKNSVEFTGNGDSFLHANHERLHTAIKFPASQKLISTKSQFISPKHQKTRKLEKHHVCSECGKAFIKKSWLTDHQVMHTGEKPHRCSLCEKAFSRKFMLTEHQRTHTGEKPYECPECGKAFLKKSRLNIHQKTHTGEKPYICSECGKGFIQKGNLIVHQRIHTGEKPYICNECGKGFIQKTCLIAHQRFHTGKTPFVCSECGKSCSQKSGLIKHQRIHTGEKPFECSECGKAFSTKQKLIVHQRTHTGERPYGCNECGKAFAYMSCLVKHKRIHTREKQEAAKVENPPAERHSSLHTSDVMQEKNSANGATTQVPSVAPQTSLNISGLLANRNVVLVGQPVVRCAASGDNRGFAQDRNLVNAVNVVVPSVINYVLFYVTENP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
186	Phosphorylation	PASQKLISTKSQFIS CHHHHHHCCCHHCCC	39.97	24719451
189	Phosphorylation	QKLISTKSQFISPKH HHHHCCCHHCCCCCH	30.34	19664994
193	Phosphorylation	STKSQFISPKHQKTR CCCHHCCCCCHHHCC	29.23	27251275
255	Phosphorylation	MLTEHQRTHTGEKPY CCCCHHHCCCCCCCC	19.74	-
257	Phosphorylation	TEHQRTHTGEKPYEC CCHHHCCCCCCCCCC	46.56	-
283	Phosphorylation	RLNIHQKTHTGEKPY CCCCCCCCCCCCCCE	20.35	30266825
285	Phosphorylation	NIHQKTHTGEKPYIC CCCCCCCCCCCCEEE	52.87	30266825
288	Acetylation	QKTHTGEKPYICSEC CCCCCCCCCEEECCC	44.45	7407661
290	Phosphorylation	THTGEKPYICSECGK CCCCCCCEEECCCCC	26.15	-
297	Acetylation	YICSECGKGFIQKGN EEECCCCCCEEEECC	63.41	7407669
313	Phosphorylation	IVHQRIHTGEKPYIC EEEEEEECCCCCEEE	44.67	28111955
318	Phosphorylation	IHTGEKPYICNECGK EECCCCCEEECCCCC	29.22	-
369	Phosphorylation	IKHQRIHTGEKPFEC CCCCEEECCCCCEEC	44.67	21712546
377	Phosphorylation	GEKPFECSECGKAFS CCCCEECCCCCCCCC	28.82	23663014
384	Phosphorylation	SECGKAFSTKQKLIV CCCCCCCCCCCEEEE	39.28	23663014
385	Phosphorylation	ECGKAFSTKQKLIVH CCCCCCCCCCEEEEE	30.92	23663014
415	Phosphorylation	GKAFAYMSCLVKHKR HHHHHHHHHHHHCCC	7.51	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN350_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN350_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN350_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRCA1_HUMAN	BRCA1	physical	11090615
TIF1B_HUMAN	TRIM28	physical	17079232
BRCA1_HUMAN	BRCA1	physical	16843262
CTIP_HUMAN	RBBP8	physical	16843262
TIF1B_HUMAN	TRIM28	physical	15596820
TIF1B_HUMAN	TRIM28	physical	22975076
TIF1B_HUMAN	TRIM28	physical	23991171
BRCA1_HUMAN	BRCA1	physical	23991171
VHL_HUMAN	VHL	physical	25749518
EP300_HUMAN	EP300	physical	25749518

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.