UBP51_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBP51_HUMAN
• UniProt AC: Q70EK9
• Protein Name: Ubiquitin carboxyl-terminal hydrolase 51 {ECO:0000303|PubMed:27083998}
• Gene Name: USP51 {ECO:0000312|HGNC:HGNC:23086}
• Organism: Homo sapiens (Human).
• Sequence Length: 711
• Subcellular Localization: Chromosome . Upon DNA damage, chromatin-bound USP51 disassociates from chromatin immediately following DNA damage and reassociates with chromatin following DNA repair.
• Protein Description: Specifically deubiquitinates 'Lys-14' (H2AK13Ub) and 'Lys-16'(H2AK15Ub) of histone H2A regulating the DNA damage response at double-strand breaks (DSBs). [PubMed: 27083998 USP51 is recruited to chromatin after DNA damage and regulates the dynamic assembly/disassembly of TP53BP1 and BRCA1. Exhibits also activity for 'Lys-27' or 'Lys-63'-linked di-ubiquitin]
• Protein Sequence: MAQVRETSLPSGSGVRWISGGGGGASPEEAVEKAGKMEEAAAGATKASSRREAEEMKLEPLQEREPAPEENLTWSSSGGDEKVLPSIPLRCHSSSSPVCPRRKPRPRPQPRARSRSQPGLSAPPPPPARPPPPPPPPPPPAPRPRAWRGSRRRSRPGSRPQTRRSCSGDLDGSGDPGGLGDWLLEVEFGQGPTGCSHVESFKVGKNWQKNLRLIYQRFVWSGTPETRKRKAKSCICHVCSTHMNRLHSCLSCVFFGCFTEKHIHKHAETKQHHLAVDLYHGVIYCFMCKDYVYDKDIEQIAKETKEKILRLLTSTSTDVSHQQFMTSGFEDKQSTCETKEQEPKLVKPKKKRRKKSVYTVGLRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMYSGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILDVLHRHSKDDSGGQEANNPNCCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCATFDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLTMKKLPIVACFHLKRFEHVGKQRRKINTFISFPLELDMTPFLASTKESRMKEGQPPTDCVPNENKYSLFAVINHHGTLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEGYLLFYHKQGLEKD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
19	Phosphorylation	GSGVRWISGGGGGAS CCCCEEECCCCCCCC	25.15	27732954
26	Phosphorylation	SGGGGGASPEEAVEK CCCCCCCCHHHHHHH	35.80	19664994
46	Acetylation	EAAAGATKASSRREA HHHHHCCHHHHHHHH	45.82	11688361
86	Phosphorylation	GDEKVLPSIPLRCHS CCCCEECCCCEECCC	32.45	24719451
95	Phosphorylation	PLRCHSSSSPVCPRR CEECCCCCCCCCCCC	41.50	27251275
96	Phosphorylation	LRCHSSSSPVCPRRK EECCCCCCCCCCCCC	24.25	24626860
158	Phosphorylation	RRRSRPGSRPQTRRS CCCCCCCCCCCCCCC	43.39	23186163
215	Phosphorylation	QKNLRLIYQRFVWSG HHHHHHHHHHHCCCC	9.76	26074081
221	Phosphorylation	IYQRFVWSGTPETRK HHHHHCCCCCHHHHH	27.73	26074081
223	Phosphorylation	QRFVWSGTPETRKRK HHHCCCCCHHHHHHH	16.67	26074081
226	Phosphorylation	VWSGTPETRKRKAKS CCCCCHHHHHHHCHH	42.57	26074081
356	Phosphorylation	KKKRRKKSVYTVGLR CCCCCCCCEEEECCH	24.32	26074081
358	Phosphorylation	KRRKKSVYTVGLRGL CCCCCCEEEECCHHH	11.64	26074081
359	Phosphorylation	RRKKSVYTVGLRGLI CCCCCEEEECCHHHH	13.12	26074081
382	Phosphorylation	NCIVQALTHIPLLKD HHHHHHHHCCHHHHH	22.30	-
565	Phosphorylation	RPEHLGSSAKIKCNS CHHHHCCCCEEECCC	31.61	28674419
567	Acetylation	EHLGSSAKIKCNSCQ HHHCCCCEEECCCCH	44.65	25953088
567	Ubiquitination	EHLGSSAKIKCNSCQ HHHCCCCEEECCCCH	44.65	32015554
597	Ubiquitination	IVACFHLKRFEHVGK EEEEEEHHHCHHCCC	46.61	-
604	Ubiquitination	KRFEHVGKQRRKINT HHCHHCCCHHHCCCE	39.27	-
611	Phosphorylation	KQRRKINTFISFPLE CHHHCCCEEECCEEE	26.31	-
622	Phosphorylation	FPLELDMTPFLASTK CEEECCCCCHHHCCH	15.57	29759185
627	Phosphorylation	DMTPFLASTKESRMK CCCCHHHCCHHHHHC	42.00	29759185
628	Phosphorylation	MTPFLASTKESRMKE CCCHHHCCHHHHHCC	32.97	24114839
679	Phosphorylation	QQKDQWFSCDDAIIT HCCCCCEECCCCEEE	17.43	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBP51_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBP51_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBP51_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
H2A2C_HUMAN	HIST2H2AC	physical	27083998
ZEB1_HUMAN	ZEB1	physical	29119051

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.