| UniProt ID | UBP4_HUMAN | |
|---|---|---|
| UniProt AC | Q13107 | |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 4 | |
| Gene Name | USP4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 963 | |
| Subcellular Localization | Cytoplasm . Nucleus . Shuttles between the nucleus and cytoplasm. Exported to the cytoplasm in a CRM1-dependent manner and recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The relative amounts found in the nucle | |
| Protein Description | Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER.. | |
| Protein Sequence | MAEGGGCRERPDAETQKSELGPLMRTTLQRGAQWYLIDSRWFKQWKKYVGFDSWDMYNVGEHNLFPGPIDNSGLFSDPESQTLKEHLIDELDYVLVPTEAWNKLLNWYGCVEGQQPIVRKVVEHGLFVKHCKVEVYLLELKLCENSDPTNVLSCHFSKADTIATIEKEMRKLFNIPAERETRLWNKYMSNTYEQLSKLDNTVQDAGLYQGQVLVIEPQNEDGTWPRQTLQSKSSTAPSRNFTTSPKSSASPYSSVSASLIANGDSTSTCGMHSSGVSRGGSGFSASYNCQEPPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKDEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLLDGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYLTLPLPLKKDRVMEVFLVPADPHCRPTQYRVTVPLMGAVSDLCEALSRLSGIAAENMVVADVYNHRFHKIFQMDEGLNHIMPRDDIFVYEVCSTSVDGSECVTLPVYFRERKSRPSSTSSASALYGQPLLLSVPKHKLTLESLYQAVCDRISRYVKQPLPDEFGSSPLEPGACNGSRNSCEGEDEEEMEHQEEGKEQLSETEGSGEDEPGNDPSETTQKKIKGQPCPKRLFTFSLVNSYGTADINSLAADGKLLKLNSRSTLAMDWDSETRRLYYDEQESEAYEKHVSMLQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRYWRDKLDTVVEFPIRGLNMSEFVCNLSARPYVYDLIAVSNHYGAMGVGHYTAYAKNKLNGKWYYFDDSNVSLASEDQIVTKAAYVLFYQRRDDEFYKTPSLSSSGSSDGGTRPSSSQQGFGDDEACSMDTN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 43 | Ubiquitination | LIDSRWFKQWKKYVG EECHHHHHHHHHHHC | 48.57 | - | |
| 120 | Ubiquitination | GQQPIVRKVVEHGLF CCCCHHHHHHHCCCE | 39.47 | - | |
| 129 | Ubiquitination | VEHGLFVKHCKVEVY HHCCCEECCCEEEEE | 35.63 | - | |
| 132 | Ubiquitination | GLFVKHCKVEVYLLE CCEECCCEEEEEEEE | 40.94 | - | |
| 136 | Phosphorylation | KHCKVEVYLLELKLC CCCEEEEEEEEEEEC | 7.64 | 21406692 | |
| 158 | Acetylation | VLSCHFSKADTIATI EEEEEECCCCHHHHH | 49.71 | 26051181 | |
| 158 | Ubiquitination | VLSCHFSKADTIATI EEEEEECCCCHHHHH | 49.71 | - | |
| 167 | Acetylation | DTIATIEKEMRKLFN CHHHHHHHHHHHHHC | 53.62 | 25953088 | |
| 167 | Ubiquitination | DTIATIEKEMRKLFN CHHHHHHHHHHHHHC | 53.62 | - | |
| 171 | Ubiquitination | TIEKEMRKLFNIPAE HHHHHHHHHHCCCCH | 57.00 | - | |
| 186 | Ubiquitination | RETRLWNKYMSNTYE HHHHHHHHHHHCHHH | 30.65 | 21890473 | |
| 186 | Ubiquitination | RETRLWNKYMSNTYE HHHHHHHHHHHCHHH | 30.65 | 21890473 | |
| 186 (in isoform 1) | Ubiquitination | - | 30.65 | 21890473 | |
| 186 (in isoform 2) | Ubiquitination | - | 30.65 | 21890473 | |
| 191 | Phosphorylation | WNKYMSNTYEQLSKL HHHHHHCHHHHHHCC | 22.56 | 28796482 | |
| 192 | Phosphorylation | NKYMSNTYEQLSKLD HHHHHCHHHHHHCCC | 13.11 | 28796482 | |
| 196 | Phosphorylation | SNTYEQLSKLDNTVQ HCHHHHHHCCCCHHC | 30.76 | - | |
| 197 | Ubiquitination | NTYEQLSKLDNTVQD CHHHHHHCCCCHHCC | 69.33 | - | |
| 228 | Phosphorylation | DGTWPRQTLQSKSST CCCCCCHHHCCCCCC | 28.22 | 29083192 | |
| 231 | Phosphorylation | WPRQTLQSKSSTAPS CCCHHHCCCCCCCCC | 37.30 | 29083192 | |
| 232 | Ubiquitination | PRQTLQSKSSTAPSR CCHHHCCCCCCCCCC | 35.15 | - | |
| 233 | Phosphorylation | RQTLQSKSSTAPSRN CHHHCCCCCCCCCCC | 37.86 | 29083192 | |
| 234 | Phosphorylation | QTLQSKSSTAPSRNF HHHCCCCCCCCCCCC | 32.12 | 29083192 | |
| 235 | Phosphorylation | TLQSKSSTAPSRNFT HHCCCCCCCCCCCCC | 50.07 | 29083192 | |
| 238 | Phosphorylation | SKSSTAPSRNFTTSP CCCCCCCCCCCCCCC | 37.07 | 29083192 | |
| 242 | Phosphorylation | TAPSRNFTTSPKSSA CCCCCCCCCCCCCCC | 29.88 | 28270605 | |
| 243 | Phosphorylation | APSRNFTTSPKSSAS CCCCCCCCCCCCCCC | 38.60 | 26074081 | |
| 244 | Phosphorylation | PSRNFTTSPKSSASP CCCCCCCCCCCCCCC | 27.55 | 23401153 | |
| 247 | Phosphorylation | NFTTSPKSSASPYSS CCCCCCCCCCCCCCC | 34.22 | 21945579 | |
| 248 | Phosphorylation | FTTSPKSSASPYSSV CCCCCCCCCCCCCCC | 38.60 | 21945579 | |
| 250 | Phosphorylation | TSPKSSASPYSSVSA CCCCCCCCCCCCCEE | 26.73 | 21945579 | |
| 252 | Phosphorylation | PKSSASPYSSVSASL CCCCCCCCCCCEEEE | 15.87 | 21945579 | |
| 253 | Phosphorylation | KSSASPYSSVSASLI CCCCCCCCCCEEEEE | 27.87 | 21945579 | |
| 254 | Phosphorylation | SSASPYSSVSASLIA CCCCCCCCCEEEEEE | 17.78 | 21945579 | |
| 256 | Phosphorylation | ASPYSSVSASLIANG CCCCCCCEEEEEECC | 17.68 | 21945579 | |
| 258 | Phosphorylation | PYSSVSASLIANGDS CCCCCEEEEEECCCC | 16.89 | 21945579 | |
| 265 | Phosphorylation | SLIANGDSTSTCGMH EEEECCCCCCCCCCC | 26.17 | 21945579 | |
| 266 | Phosphorylation | LIANGDSTSTCGMHS EEECCCCCCCCCCCC | 32.56 | 21945579 | |
| 267 | Phosphorylation | IANGDSTSTCGMHSS EECCCCCCCCCCCCC | 26.17 | 21945579 | |
| 268 | Phosphorylation | ANGDSTSTCGMHSSG ECCCCCCCCCCCCCC | 17.11 | 21945579 | |
| 273 | Phosphorylation | TSTCGMHSSGVSRGG CCCCCCCCCCCCCCC | 21.64 | 21945579 | |
| 274 | Phosphorylation | STCGMHSSGVSRGGS CCCCCCCCCCCCCCC | 28.65 | 21945579 | |
| 277 | Phosphorylation | GMHSSGVSRGGSGFS CCCCCCCCCCCCCCC | 28.82 | 21945579 | |
| 301 (in isoform 2) | Ubiquitination | - | 2.39 | 21890473 | |
| 348 | Ubiquitination | RDNPLGMKGEIAEAY CCCCCCHHHHHHHHH | 52.15 | 21906983 | |
| 348 (in isoform 1) | Ubiquitination | - | 52.15 | 21890473 | |
| 355 | Phosphorylation | KGEIAEAYAELIKQM HHHHHHHHHHHHHHH | 7.66 | 27642862 | |
| 364 | Phosphorylation | ELIKQMWSGRDAHVA HHHHHHHCCCCCCCC | 20.71 | - | |
| 376 | Ubiquitination | HVAPRMFKTQVGRFA CCCCHHHHHCCCCCC | 28.80 | - | |
| 414 | Ubiquitination | EDLNRVKKKPYLELK HHHHHHHCCCCEEEE | 57.00 | - | |
| 415 | Ubiquitination | DLNRVKKKPYLELKD HHHHHHCCCCEEEEC | 32.93 | - | |
| 433 | Ubiquitination | RPDAVVAKEAWENHR CCCEEEEHHHHHHCC | 36.03 | - | |
| 445 | Phosphorylation | NHRLRNDSVIVDTFH HCCCCCCCEEEECCC | 19.79 | 28464451 | |
| 458 | Phosphorylation | FHGLFKSTLVCPECA CCHHHHHCEECCCCC | 24.65 | - | |
| 539 | Phosphorylation | NMVVADVYNHRFHKI CCEEEEHHHCCHHHH | 13.05 | - | |
| 545 | Ubiquitination | VYNHRFHKIFQMDEG HHHCCHHHHEECCCC | 42.37 | - | |
| 588 | Ubiquitination | PVYFRERKSRPSSTS EEEEEECCCCCCCCC | 46.17 | - | |
| 589 | Phosphorylation | VYFRERKSRPSSTSS EEEEECCCCCCCCCC | 56.49 | 28450419 | |
| 592 | Phosphorylation | RERKSRPSSTSSASA EECCCCCCCCCCHHH | 45.17 | 28450419 | |
| 593 | Phosphorylation | ERKSRPSSTSSASAL ECCCCCCCCCCHHHH | 34.68 | 28450419 | |
| 594 | Phosphorylation | RKSRPSSTSSASALY CCCCCCCCCCHHHHH | 30.91 | 28450419 | |
| 595 | Phosphorylation | KSRPSSTSSASALYG CCCCCCCCCHHHHHC | 26.34 | 28450419 | |
| 596 | Phosphorylation | SRPSSTSSASALYGQ CCCCCCCCHHHHHCC | 26.74 | 30576142 | |
| 598 | Phosphorylation | PSSTSSASALYGQPL CCCCCCHHHHHCCCE | 22.28 | 28450419 | |
| 601 | Phosphorylation | TSSASALYGQPLLLS CCCHHHHHCCCEEEC | 17.27 | 28450419 | |
| 608 | Phosphorylation | YGQPLLLSVPKHKLT HCCCEEECCCCHHCC | 36.02 | 24719451 | |
| 611 | Ubiquitination | PLLLSVPKHKLTLES CEEECCCCHHCCHHH | 51.74 | - | |
| 613 | Ubiquitination | LLSVPKHKLTLESLY EECCCCHHCCHHHHH | 49.66 | - | |
| 628 | Phosphorylation | QAVCDRISRYVKQPL HHHHHHHHHHCCCCC | 20.60 | 19651622 | |
| 632 | Ubiquitination | DRISRYVKQPLPDEF HHHHHHCCCCCCCCC | 36.95 | - | |
| 641 | Phosphorylation | PLPDEFGSSPLEPGA CCCCCCCCCCCCCCC | 33.82 | 28348404 | |
| 642 | Phosphorylation | LPDEFGSSPLEPGAC CCCCCCCCCCCCCCC | 33.61 | 21815630 | |
| 652 | Phosphorylation | EPGACNGSRNSCEGE CCCCCCCCCCCCCCC | 17.81 | 28348404 | |
| 655 | Phosphorylation | ACNGSRNSCEGEDEE CCCCCCCCCCCCCHH | 16.66 | 25849741 | |
| 675 | Phosphorylation | EEGKEQLSETEGSGE HHHHHHHHHCCCCCC | 42.01 | 23401153 | |
| 677 | Phosphorylation | GKEQLSETEGSGEDE HHHHHHHCCCCCCCC | 42.12 | 29255136 | |
| 680 | Phosphorylation | QLSETEGSGEDEPGN HHHHCCCCCCCCCCC | 32.55 | 23401153 | |
| 690 | Phosphorylation | DEPGNDPSETTQKKI CCCCCCCCHHHHHHH | 50.90 | 23186163 | |
| 692 | Phosphorylation | PGNDPSETTQKKIKG CCCCCCHHHHHHHCC | 38.57 | 23186163 | |
| 728 | Ubiquitination | NSLAADGKLLKLNSR HHHHCCCCEEEECCC | 51.71 | - | |
| 731 | Ubiquitination | AADGKLLKLNSRSTL HCCCCEEEECCCCCE | 56.93 | - | |
| 750 | Phosphorylation | DSETRRLYYDEQESE CHHHCCCCCCHHHHH | 13.68 | - | |
| 751 | Phosphorylation | SETRRLYYDEQESEA HHHCCCCCCHHHHHH | 20.00 | - | |
| 756 | Phosphorylation | LYYDEQESEAYEKHV CCCCHHHHHHHHHHH | 27.50 | - | |
| 759 | Phosphorylation | DEQESEAYEKHVSML CHHHHHHHHHHHHHH | 22.81 | - | |
| 764 (in isoform 2) | Ubiquitination | - | 17.31 | 21890473 | |
| 770 | Ubiquitination | VSMLQPQKKKKTTVA HHHHCCCCCCCHHHH | 73.56 | - | |
| 775 | Phosphorylation | PQKKKKTTVALRDCI CCCCCCHHHHHHHHH | 16.80 | 24719451 | |
| 790 (in isoform 2) | Ubiquitination | - | 29.28 | 21890473 | |
| 811 | Ubiquitination | KHQQATKKFDLWSLP HHCCCCHHCCCCCCC | 39.49 | 21890473 | |
| 811 (in isoform 1) | Ubiquitination | - | 39.49 | 21890473 | |
| 829 | Phosphorylation | VVHLKRFSYNRYWRD EEEEHHCCCCHHHHH | 26.07 | 24719451 | |
| 837 | Ubiquitination | YNRYWRDKLDTVVEF CCHHHHHCCCEEEEE | 39.42 | 2190698 | |
| 837 (in isoform 1) | Ubiquitination | - | 39.42 | 21890473 | |
| 916 | Phosphorylation | QIVTKAAYVLFYQRR HHHHHHHHHHEEECC | 11.53 | 28152594 | |
| 935 | Phosphorylation | YKTPSLSSSGSSDGG CCCCCCCCCCCCCCC | 43.97 | 27251275 | |
| 936 | Phosphorylation | KTPSLSSSGSSDGGT CCCCCCCCCCCCCCC | 39.04 | 27251275 | |
| 938 | Phosphorylation | PSLSSSGSSDGGTRP CCCCCCCCCCCCCCC | 27.49 | 27251275 | |
| 939 | Phosphorylation | SLSSSGSSDGGTRPS CCCCCCCCCCCCCCC | 43.74 | 27251275 | |
| 943 | Phosphorylation | SGSSDGGTRPSSSQQ CCCCCCCCCCCCCCC | 44.96 | 27251275 | |
| 946 | Phosphorylation | SDGGTRPSSSQQGFG CCCCCCCCCCCCCCC | 39.05 | 27251275 | |
| 947 | Phosphorylation | DGGTRPSSSQQGFGD CCCCCCCCCCCCCCC | 34.54 | 28348404 | |
| 948 | Phosphorylation | GGTRPSSSQQGFGDD CCCCCCCCCCCCCCC | 30.75 | 30576142 | |
| 959 | Phosphorylation | FGDDEACSMDTN--- CCCCCCCCCCCC--- | 27.09 | 30576142 | |
| 962 | Phosphorylation | DEACSMDTN------ CCCCCCCCC------ | 33.90 | 30576142 |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of UBP4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of UBP4_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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