AT1B3_HUMAN - dbPTM
AT1B3_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID AT1B3_HUMAN
UniProt AC P54709
Protein Name Sodium/potassium-transporting ATPase subunit beta-3
Gene Name ATP1B3
Organism Homo sapiens (Human).
Sequence Length 279
Subcellular Localization Cell membrane
Single-pass type II membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Protein Description This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known..
Protein Sequence MTKNEKKSLNQSLAEWKLFIYNPTTGEFLGRTAKSWGLILLFYLVFYGFLAALFSFTMWVMLQTLNDEVPKYRDQIPSPGLMVFPKPVTALEYTFSRSDPTSYAGYIEDLKKFLKPYTLEEQKNLTVCPDGALFEQKGPVYVACQFPISLLQACSGMNDPDFGYSQGNPCILVKMNRIIGLKPEGVPRIDCVSKNEDIPNVAVYPHNGMIDLKYFPYYGKKLHVGYLQPLVAVQVSFAPNNTGKEVTVECKIDGSANLKSQDDRDKFLGRVMFKITARA
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3Ubiquitination-----MTKNEKKSLN
-----CCHHHHHHHH		62.9123000965
6Ubiquitination--MTKNEKKSLNQSL
--CCHHHHHHHHHHH		57.9923000965
7Ubiquitination-MTKNEKKSLNQSLA
-CCHHHHHHHHHHHH		54.7323000965
8PhosphorylationMTKNEKKSLNQSLAE
CCHHHHHHHHHHHHH		43.5528188228
12PhosphorylationEKKSLNQSLAEWKLF
HHHHHHHHHHHEEEE		28.5925159151
17UbiquitinationNQSLAEWKLFIYNPT
HHHHHHEEEEEECCC		25.6521906983
72UbiquitinationLNDEVPKYRDQIPSP
HCCCCCHHHHCCCCC		17.22-
86UbiquitinationPGLMVFPKPVTALEY
CCEEEECCCEEEEEE		40.4321963094
97UbiquitinationALEYTFSRSDPTSYA
EEEEEEECCCCCCCH		40.6721906983
98UbiquitinationLEYTFSRSDPTSYAG
EEEEEECCCCCCCHH		46.90-
98PhosphorylationLEYTFSRSDPTSYAG
EEEEEECCCCCCCHH		46.9028152594
101PhosphorylationTFSRSDPTSYAGYIE
EEECCCCCCCHHHHH		39.0828152594
101UbiquitinationTFSRSDPTSYAGYIE
EEECCCCCCCHHHHH		39.0821906983
102PhosphorylationFSRSDPTSYAGYIED
EECCCCCCCHHHHHH		20.5528152594
103PhosphorylationSRSDPTSYAGYIEDL
ECCCCCCCHHHHHHH		13.4128152594
106PhosphorylationDPTSYAGYIEDLKKF
CCCCCHHHHHHHHHH		7.9328152594
109UbiquitinationSYAGYIEDLKKFLKP
CCHHHHHHHHHHHCC		54.98-
111AcetylationAGYIEDLKKFLKPYT
HHHHHHHHHHHCCCC		54.5226051181
111UbiquitinationAGYIEDLKKFLKPYT
HHHHHHHHHHHCCCC		54.5221906983
112UbiquitinationGYIEDLKKFLKPYTL
HHHHHHHHHHCCCCH		64.3321963094
112AcetylationGYIEDLKKFLKPYTL
HHHHHHHHHHCCCCH		64.337851841
115UbiquitinationEDLKKFLKPYTLEEQ
HHHHHHHCCCCHHHH		38.8321906983
123UbiquitinationPYTLEEQKNLTVCPD
CCCHHHHCCCEECCC		58.1529967540
124N-linked_GlycosylationYTLEEQKNLTVCPDG
CCHHHHCCCEECCCC		40.4117660510
137UbiquitinationDGALFEQKGPVYVAC
CCHHHCCCCCEEEEE		58.9729967540
160UbiquitinationACSGMNDPDFGYSQG
HHCCCCCCCCCCCCC		33.55-
168UbiquitinationDFGYSQGNPCILVKM
CCCCCCCCEEEEEEC		22.1921906983
174UbiquitinationGNPCILVKMNRIIGL
CCEEEEEECCCCCCC		27.3221963094
182AcetylationMNRIIGLKPEGVPRI
CCCCCCCCCCCCCCE		35.4926051181
182UbiquitinationMNRIIGLKPEGVPRI
CCCCCCCCCCCCCCE		35.4921906983
194AcetylationPRIDCVSKNEDIPNV
CCEECEECCCCCCCE		43.9126051181
194UbiquitinationPRIDCVSKNEDIPNV
CCEECEECCCCCCCE		43.9121963094
213UbiquitinationHNGMIDLKYFPYYGK
CCCEEEEEEECCCCC		40.8921906983
2202-HydroxyisobutyrylationKYFPYYGKKLHVGYL
EEECCCCCEEEEECC		35.72-
220UbiquitinationKYFPYYGKKLHVGYL
EEECCCCCEEEEECC		35.7221963094
221UbiquitinationYFPYYGKKLHVGYLQ
EECCCCCEEEEECCC		39.1922817900
240N-linked_GlycosylationVQVSFAPNNTGKEVT
EEEEECCCCCCCEEE		56.0912754519
240N-linked_GlycosylationVQVSFAPNNTGKEVT
EEEEECCCCCCCEEE		56.0912754519
241N-linked_GlycosylationQVSFAPNNTGKEVTV
EEEECCCCCCCEEEE		49.50-
241N-linked_GlycosylationQVSFAPNNTGKEVTV
EEEECCCCCCCEEEE		49.5019349973
251UbiquitinationKEVTVECKIDGSANL
CEEEEEEEECCCCCC		30.2629967540
259UbiquitinationIDGSANLKSQDDRDK
ECCCCCCCCHHHHHH		45.9721906983
266UbiquitinationKSQDDRDKFLGRVMF
CCHHHHHHHHHHHHH		43.3029967540
274UbiquitinationFLGRVMFKITARA--
HHHHHHHEEEECC--		22.5029967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of AT1B3_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of AT1B3_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of AT1B3_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
T131L_HUMANKIAA0922physical
26186194
EMC1_HUMANEMC1physical
26186194
AT12A_HUMANATP12Aphysical
26186194
TECT2_HUMANTCTN2physical
26186194
1C07_HUMANHLA-Cphysical
26186194
PIGO_HUMANPIGOphysical
26186194
ALG9_HUMANALG9physical
26186194
K2013_HUMANKIAA2013physical
26186194
PMGT2_HUMANPOMGNT2physical
26186194
MANEL_HUMANMANEALphysical
26186194
REEP5_HUMANREEP5physical
26186194
SCRB1_HUMANSCARB1physical
26186194
LNP_HUMANKIAA1715physical
26186194
TM9S4_HUMANTM9SF4physical
26186194
PCD20_HUMANPCDH20physical
26186194
CD032_HUMANC4orf32physical
26186194
ABCA3_HUMANABCA3physical
26186194
F234B_HUMANKIAA1467physical
26186194
TBB8_HUMANTUBB8physical
26186194
HMDH_HUMANHMGCRphysical
26186194
MBRL_HUMANTMEM259physical
26186194
FADS2_HUMANFADS2physical
26186194
EFNB1_HUMANEFNB1physical
26186194
GLBL2_HUMANGLB1L2physical
26186194
ITA7_HUMANITGA7physical
26186194
RTN4_HUMANRTN4physical
26186194
TM9S2_HUMANTM9SF2physical
26186194
PXYP1_HUMANPXYLP1physical
26186194
TMPPE_HUMANTMPPEphysical
26186194
SEM4C_HUMANSEMA4Cphysical
26186194
ABHD3_HUMANABHD3physical
26186194
POMT1_HUMANPOMT1physical
26186194
PRAF3_HUMANARL6IP5physical
26186194
IMPA3_HUMANIMPAD1physical
26186194
GALT7_HUMANGALNT7physical
26186194
SEM4F_HUMANSEMA4Fphysical
26186194
EMC7_HUMANEMC7physical
26186194
RTN2_HUMANRTN2physical
26186194
NRP2_HUMANNRP2physical
26186194
BACE2_HUMANBACE2physical
26186194
BT2A2_HUMANBTN2A2physical
26186194
TGBR3_HUMANTGFBR3physical
26186194
CJ035_HUMANC10orf35physical
26186194
ITB5_HUMANITGB5physical
26186194
THIM_HUMANACAA2physical
26344197
THIL_HUMANACAT1physical
26344197
AN32B_HUMANANP32Bphysical
26344197
AT1A1_HUMANATP1A1physical
26344197
AT1A3_HUMANATP1A3physical
26344197
AT5F1_HUMANATP5F1physical
26344197
VA0D1_HUMANATP6V0D1physical
26344197
VATE1_HUMANATP6V1E1physical
26344197
CPT2_HUMANCPT2physical
26344197
CYB5B_HUMANCYB5Bphysical
26344197
CY1_HUMANCYC1physical
26344197
DLDH_HUMANDLDphysical
26344197
EF2_HUMANEEF2physical
26344197
HCD2_HUMANHSD17B10physical
26344197
ITA5_HUMANITGA5physical
26344197
MTCH1_HUMANMTCH1physical
26344197
MTCH2_HUMANMTCH2physical
26344197
MYH2_HUMANMYH2physical
26344197
NDUAC_HUMANNDUFA12physical
26344197
NDUA2_HUMANNDUFA2physical
26344197
NDUA8_HUMANNDUFA8physical
26344197
NDUA9_HUMANNDUFA9physical
26344197
NDUB7_HUMANNDUFB7physical
26344197
NDUS1_HUMANNDUFS1physical
26344197
NDUS3_HUMANNDUFS3physical
26344197
NDUS5_HUMANNDUFS5physical
26344197
ODO1_HUMANOGDHphysical
26344197
PSMD6_HUMANPSMD6physical
26344197
SYQ_HUMANQARSphysical
26344197
RAB1A_HUMANRAB1Aphysical
26344197
RAB1B_HUMANRAB1Bphysical
26344197
RL10_HUMANRPL10physical
26344197
RL17_HUMANRPL17physical
26344197
RL22_HUMANRPL22physical
26344197
RL26_HUMANRPL26physical
26344197
RL35_HUMANRPL35physical
26344197
RLA2_HUMANRPLP2physical
26344197
RS19_HUMANRPS19physical
26344197
RS8_HUMANRPS8physical
26344197
RS9_HUMANRPS9physical
26344197
RTN3_HUMANRTN3physical
26344197
RTN4_HUMANRTN4physical
26344197
TOM40_HUMANTOMM40physical
26344197
QCR7_HUMANUQCRBphysical
26344197
VDAC1_HUMANVDAC1physical
26344197
VDAC2_HUMANVDAC2physical
26344197
VDAC3_HUMANVDAC3physical
26344197
LNP_HUMANKIAA1715physical
28514442
CD032_HUMANC4orf32physical
28514442
EFNB1_HUMANEFNB1physical
28514442
TGBR3_HUMANTGFBR3physical
28514442
AT12A_HUMANATP12Aphysical
28514442
BT2A2_HUMANBTN2A2physical
28514442
BACE2_HUMANBACE2physical
28514442
PRAF3_HUMANARL6IP5physical
28514442
RTN4_HUMANRTN4physical
28514442
ALG9_HUMANALG9physical
28514442
ITB5_HUMANITGB5physical
28514442
ITA7_HUMANITGA7physical
28514442
NRP2_HUMANNRP2physical
28514442
EMC1_HUMANEMC1physical
28514442
TBB8_HUMANTUBB8physical
28514442
CJ035_HUMANC10orf35physical
28514442
1C07_HUMANHLA-Cphysical
28514442
GRN_HUMANGRNphysical
28514442
TMPPE_HUMANTMPPEphysical
28514442
RTN2_HUMANRTN2physical
28514442
MANEL_HUMANMANEALphysical
28514442
PIGO_HUMANPIGOphysical
28514442
TMX4_HUMANTMX4physical
28514442
CGRF1_HUMANCGRRF1physical
28514442
IMPA3_HUMANIMPAD1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00112 G-Strophanthin (JAN); Ouabain; Ouabain octahydrate
D00297 Digitoxin (JP16/USP/INN); Crystodigin (TN)
D00298 Digoxin (JP16/USP); Lanoxicaps (TN); Lanoxin (TN)
D01240 Deslanoside (JP16/USP/INN); Cedilanid-d (TN)
D01379 Proscillaridin (JAN/USAN/INN); Talusin (TN)
D01972 Lanatoside C (JP16/INN); Digilanogen C (TN)
D02587 Metildigoxin (JP16); Lanirapid (TN)
D06881 Acetyldigitoxin (INN); Acylanid (TN)
D07147 Gitoformate (INN)
D07555 Acetyldigoxin; Cedigossima (TN)
D07556 beta-Acetyldigoxin; Acetyldigoxin beta isomer; Corotal (TN)
D09847 Metildigoxin (INN); Medigoxin (BAN)
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of AT1B3_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Identification and quantification of N-linked glycoproteins usinghydrazide chemistry, stable isotope labeling and mass spectrometry.";
Zhang H., Li X.-J., Martin D.B., Aebersold R.;
Nat. Biotechnol. 21:660-666(2003).
Cited for: GLYCOSYLATION AT ASN-240.

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