PMGT2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PMGT2_HUMAN
• UniProt AC: Q8NAT1
• Protein Name: Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 {ECO:0000303|PubMed:23929950}
• Gene Name: POMGNT2
• Organism: Homo sapiens (Human).
• Sequence Length: 580
• Subcellular Localization: Endoplasmic reticulum membrane ; Single-pass type II membrane protein .
• Protein Description: O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity..
• Protein Sequence: MHLSAVFNALLVSVLAAVLWKHVRLREHAATLEEELALSRQATEPAPALRIDYPKALQILMEGGTHMVCTGRTHTDRICRFKWLCYSNEAEEFIFFHGNTSVMLPNLGSRRFQPALLDLSTVEDHNTQYFNFVELPAAALRFMPKPVFVPDVALIANRFNPDNLMHVFHDDLLPLFYTLRQFPGLAHEARLFFMEGWGEGAHFDLYKLLSPKQPLLRAQLKTLGRLLCFSHAFVGLSKITTWYQYGFVQPQGPKANILVSGNEIRQFARFMTEKLNVSHTGVPLGEEYILVFSRTQNRLILNEAELLLALAQEFQMKTVTVSLEDHTFADVVRLVSNASMLVSMHGAQLVTTLFLPRGATVVELFPYAVNPDHYTPYKTLAMLPGMDLQYVAWRNMMPENTVTHPERPWDQGGITHLDRAEQARILQSREVPRHLCCRNPEWLFRIYQDTKVDIPSLIQTIRRVVKGRPGPRKQKWTVGLYPGKVREARCQASVHGASEARLTVSWQIPWNLKYLKVREVKYEVWLQEQGENTYVPYILALQNHTFTENIKPFTTYLVWVRCIFNKILLGPFADVLVCNT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
13	Phosphorylation	VFNALLVSVLAAVLW HHHHHHHHHHHHHHH		50563987
39	Phosphorylation	LEEELALSRQATEPA HHHHHHHHCCCCCCC		24719451
43	O-linked_Glycosylation	LALSRQATEPAPALR HHHHCCCCCCCCCCC		55831349
65	Phosphorylation	QILMEGGTHMVCTGR HHHHCCCCEEEECCC		46160439
70	Phosphorylation	GGTHMVCTGRTHTDR CCCEEEECCCCCHHC		46160445
86	Phosphorylation	CRFKWLCYSNEAEEF EEEEEEEECCCCCEE		24043423
87	Phosphorylation	RFKWLCYSNEAEEFI EEEEEEECCCCCEEE		24043423
99	N-linked_Glycosylation	EFIFFHGNTSVMLPN EEEEEECCCEEECCC		UniProtKB CARBOHYD
100	Phosphorylation	FIFFHGNTSVMLPNL EEEEECCCEEECCCC		24043423
101	Phosphorylation	IFFHGNTSVMLPNLG EEEECCCEEECCCCC		24043423
109	Phosphorylation	VMLPNLGSRRFQPAL EECCCCCCCCCCEEE		24043423
145	Ubiquitination	AALRFMPKPVFVPDV HHHHHCCCCCCCCCH		-
178	Phosphorylation	DLLPLFYTLRQFPGL CHHHHHHHHHHCCCC		24719451
210	Phosphorylation	FDLYKLLSPKQPLLR CCHHHHCCCCCHHHH		24719451
276	N-linked_Glycosylation	RFMTEKLNVSHTGVP HHHHHCCCCCCCCCC		UniProtKB CARBOHYD
379	Phosphorylation	DHYTPYKTLAMLPGM CCCCCCHHHHCCCCC		68744237
390	Phosphorylation	LPGMDLQYVAWRNMM CCCCCHHHHHHHHCC		68744243
493	Phosphorylation	REARCQASVHGASEA CEEEEEEEECCCCCE		68699121

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PMGT2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PMGT2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PMGT2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
NT2NL_HUMAN	NOTCH2NL	physical	25416956
PECR_HUMAN	PECR	physical	28514442
FKB14_HUMAN	FKBP14	physical	28514442
NOB1_HUMAN	NOB1	physical	28514442
IF4E2_HUMAN	EIF4E2	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.