dbPTM

FKB14_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	FKB14_HUMAN
UniProt AC	Q9NWM8
Protein Name	Peptidyl-prolyl cis-trans isomerase FKBP14
Gene Name	FKBP14
Organism	Homo sapiens (Human).
Sequence Length	211
Subcellular Localization	Endoplasmic reticulum lumen .
Protein Description	PPIase which accelerates the folding of proteins during protein synthesis. Has a preference for substrates containing 4-hydroxylproline modifications, including type III collagen. May also target type VI and type X collagens..
Protein Sequence	MRLFLWNAVLTLFVTSLIGALIPEPEVKIEVLQKPFICHRKTKGGDLMLVHYEGYLEKDGSLFHSTHKHNNGQPIWFTLGILEALKGWDQGLKGMCVGEKRKLIIPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWKLSKDEVKAYLKKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFTYKHDEL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Acetylation	KGWDQGLKGMCVGEK CCCCCCCCCEECCCC	51.96	30588791
100	Acetylation	KGMCVGEKRKLIIPP CCEECCCCEEEEECC	49.24	30588797
161	Ubiquitination	KLSKDEVKAYLKKEF CCCHHHHHHHHHHHH	29.30	-
176	N-linked_Glycosylation	EKHGAVVNESHHDAL HHHCCCCCCCHHHHH	38.15	UniProtKB CARBOHYD
207	"N6,N6-dimethyllysine"	SAREFTYKHDEL--- EEEEEEECCCCC---	41.33	-
207	Methylation	SAREFTYKHDEL--- EEEEEEECCCCC---	41.33	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of FKB14_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of FKB14_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of FKB14_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HS74L_HUMAN	HSPA4L	physical	26344197
PLSL_HUMAN	LCP1	physical	26344197
PLSI_HUMAN	PLS1	physical	26344197
IPYR2_HUMAN	PPA2	physical	26344197

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of FKB14_HUMAN

Related Literatures of Post-Translational Modification