PLSI_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLSI_HUMAN
• UniProt AC: Q14651
• Protein Name: Plastin-1
• Gene Name: PLS1
• Organism: Homo sapiens (Human).
• Sequence Length: 629
• Subcellular Localization: Cytoplasm.
• Protein Description: Actin-bundling protein in the absence of calcium..
• Protein Sequence: MENSTTTISREELEELQEAFNKIDIDNSGYVSDYELQDLFKEASLPLPGYKVREIVEKILSVADSNKDGKISFEEFVSLMQELKSKDISKTFRKIINKREGITAIGGTSTISSEGTQHSYSEEEKVAFVNWINKALENDPDCKHLIPMNPNDDSLFKSLADGILLCKMINLSEPDTIDERAINKKKLTPFTISENLNLALNSASAIGCTVVNIGASDLKEGKPHLVLGLLWQIIKVGLFADIEISRNEALIALLNEGEELEELMKLSPEELLLRWVNYHLTNAGWHTISNFSQDIKDSRAYFHLLNQIAPKGGEDGPAIAIDLSGINETNDLKRAGLMLQEADKLGCKQFVTPADVVSGNPKLNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESKEERTFRNWMNSLGVNPYINHLYSDLADALVIFQLYEMIRVPVNWSHVNKPPYPALGGNMKKIENCNYAVELGKNKAKFSLVGIAGQDLNEGNSTLTLALVWQLMRRYTLNVLSDLGEGEKVNDEIIIKWVNQTLKSANKKTSISSFKDKSISTSLPVLDLIDAIAPNAVRQEMIRRENLSDEDKLNNAKYAISVARKIGARIYALPDDLVEVKPKMVMTVFACLMGKGLNRIK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MENSTTTI -------CCCCCCCC	11.25	22814378
4	Phosphorylation	----MENSTTTISRE ----CCCCCCCCCHH	17.52	20860994
5	Phosphorylation	---MENSTTTISREE ---CCCCCCCCCHHH	39.27	24043423
6	Phosphorylation	--MENSTTTISREEL --CCCCCCCCCHHHH	23.19	24043423
7	Phosphorylation	-MENSTTTISREELE -CCCCCCCCCHHHHH	19.62	24043423
9	Phosphorylation	ENSTTTISREELEEL CCCCCCCCHHHHHHH	31.39	24043423
30	Phosphorylation	IDIDNSGYVSDYELQ CCCCCCCCCCHHHHH	9.15	27642862
32	Phosphorylation	IDNSGYVSDYELQDL CCCCCCCCHHHHHHH	26.45	27690223
34	Phosphorylation	NSGYVSDYELQDLFK CCCCCCHHHHHHHHH	15.84	27642862
58	Ubiquitination	KVREIVEKILSVADS HHHHHHHHHHHHHCC	37.74	29967540
67	Ubiquitination	LSVADSNKDGKISFE HHHHCCCCCCCCCHH	72.34	33845483
78	Phosphorylation	ISFEEFVSLMQELKS CCHHHHHHHHHHHHH	24.36	-
90	Acetylation	LKSKDISKTFRKIIN HHHCCCHHHHHHHHH	52.60	-
93	Methylation	KDISKTFRKIINKRE CCCHHHHHHHHHHCC	34.20	24390943
103	Phosphorylation	INKREGITAIGGTST HHHCCCCEEECCCEE	24.07	23312004
108	Phosphorylation	GITAIGGTSTISSEG CCEEECCCEECCCCC	19.93	23312004
109	Phosphorylation	ITAIGGTSTISSEGT CEEECCCEECCCCCC	27.33	23312004
110	Phosphorylation	TAIGGTSTISSEGTQ EEECCCEECCCCCCC	25.39	23312004
112	Phosphorylation	IGGTSTISSEGTQHS ECCCEECCCCCCCCC	23.56	23312004
113	Phosphorylation	GGTSTISSEGTQHSY CCCEECCCCCCCCCC	35.87	23312004
116	Phosphorylation	STISSEGTQHSYSEE EECCCCCCCCCCCHH	21.03	23312004
119	Phosphorylation	SSEGTQHSYSEEEKV CCCCCCCCCCHHHHH	22.12	23312004
120	Phosphorylation	SEGTQHSYSEEEKVA CCCCCCCCCHHHHHH	20.27	23312004
121	Phosphorylation	EGTQHSYSEEEKVAF CCCCCCCCHHHHHHH	41.36	23312004
134	Ubiquitination	AFVNWINKALENDPD HHHHHHHHHHHCCCC	45.26	22817900
143	Ubiquitination	LENDPDCKHLIPMNP HHCCCCCCCCCCCCC	49.15	32015554
154	Phosphorylation	PMNPNDDSLFKSLAD CCCCCCCHHHHHHHH	38.27	24719451
168	Sulfoxidation	DGILLCKMINLSEPD HHHHHHHHCCCCCCC	2.10	21406390
172	Phosphorylation	LCKMINLSEPDTIDE HHHHCCCCCCCCCCH	42.46	21406692
176	Phosphorylation	INLSEPDTIDERAIN CCCCCCCCCCHHHCC	40.83	21406692
267	Phosphorylation	LEELMKLSPEELLLR HHHHHCCCHHHHHHH	25.42	21815630
278	Phosphorylation	LLLRWVNYHLTNAGW HHHHHHHHHHHCCCC	6.65	20873877
281	Phosphorylation	RWVNYHLTNAGWHTI HHHHHHHHCCCCHHH	15.09	20873877
287	Phosphorylation	LTNAGWHTISNFSQD HHCCCCHHHHCCCCH	21.42	20873877
289	Phosphorylation	NAGWHTISNFSQDIK CCCCHHHHCCCCHHH	32.74	20873877
292	Phosphorylation	WHTISNFSQDIKDSR CHHHHCCCCHHHHHH	31.06	20873877
296	Acetylation	SNFSQDIKDSRAYFH HCCCCHHHHHHHHHH	58.92	-
301	Phosphorylation	DIKDSRAYFHLLNQI HHHHHHHHHHHHHHH	7.16	28152594
311	Ubiquitination	LLNQIAPKGGEDGPA HHHHHCCCCCCCCCE	71.21	16196087
324	Phosphorylation	PAIAIDLSGINETND CEEEEECCCCCCCCH	33.60	-
333	Acetylation	INETNDLKRAGLMLQ CCCCCHHHHHHHCHH	42.96	7824077
333	Ubiquitination	INETNDLKRAGLMLQ CCCCCHHHHHHHCHH	42.96	22817900
352	Phosphorylation	LGCKQFVTPADVVSG CCCCCCCCHHHHHCC	17.66	21815630
358	Phosphorylation	VTPADVVSGNPKLNL CCHHHHHCCCCCCHH	32.47	27251275
362	Acetylation	DVVSGNPKLNLAFVA HHHCCCCCCHHHHHH	54.74	-
407	Phosphorylation	TFRNWMNSLGVNPYI HHHHHHHHCCCCHHH	15.47	-
431	Phosphorylation	ALVIFQLYEMIRVPV HHHHHHHHHHHCCCC	7.83	-
456	Acetylation	PALGGNMKKIENCNY CCCCCCCHHCCCCCE	55.38	7987787
457	Acetylation	ALGGNMKKIENCNYA CCCCCCHHCCCCCEE	44.47	26051181
457	Ubiquitination	ALGGNMKKIENCNYA CCCCCCHHCCCCCEE	44.47	16196087
469	Ubiquitination	NYAVELGKNKAKFSL CEEHHCCCCCCEEEE	68.82	16196087
473	Acetylation	ELGKNKAKFSLVGIA HCCCCCCEEEEEEEE	36.78	-
475	Phosphorylation	GKNKAKFSLVGIAGQ CCCCCEEEEEEEECC	22.80	24043423
489	Phosphorylation	QDLNEGNSTLTLALV CCCCCCCHHHHHHHH	35.33	24043423
490	Phosphorylation	DLNEGNSTLTLALVW CCCCCCHHHHHHHHH	27.97	24043423
492	Phosphorylation	NEGNSTLTLALVWQL CCCCHHHHHHHHHHH	15.29	24043423
503	Phosphorylation	VWQLMRRYTLNVLSD HHHHHHHHHHHHHHC	12.76	30631047
504	Phosphorylation	WQLMRRYTLNVLSDL HHHHHHHHHHHHHCC	15.28	30631047
509	Phosphorylation	RYTLNVLSDLGEGEK HHHHHHHHCCCCCCC	26.89	20068231
524	Ubiquitination	VNDEIIIKWVNQTLK CCHHHHHHHHHHHHH	34.38	33845483
531	Ubiquitination	KWVNQTLKSANKKTS HHHHHHHHHCCCCCC	51.41	29967540
540	Phosphorylation	ANKKTSISSFKDKSI CCCCCCHHHHCCCCC	29.50	23312004
541	Phosphorylation	NKKTSISSFKDKSIS CCCCCHHHHCCCCCC	34.35	23312004
543	Acetylation	KTSISSFKDKSISTS CCCHHHHCCCCCCCC	67.22	25953088
546	Phosphorylation	ISSFKDKSISTSLPV HHHHCCCCCCCCCCH	31.72	25332170
549	Phosphorylation	FKDKSISTSLPVLDL HCCCCCCCCCCHHHH	32.39	25332170
550	Phosphorylation	KDKSISTSLPVLDLI CCCCCCCCCCHHHHH	24.72	25332170
580	Acetylation	ENLSDEDKLNNAKYA CCCCCHHHHHHHHHH	51.58	-
585	Ubiquitination	EDKLNNAKYAISVAR HHHHHHHHHHHHHHH	37.02	24816145
593	Ubiquitination	YAISVARKIGARIYA HHHHHHHHHCCEEEE	35.44	-
599	Phosphorylation	RKIGARIYALPDDLV HHHCCEEEECCHHHC	9.13	-
609	Ubiquitination	PDDLVEVKPKMVMTV CHHHCCCCHHHHHHH	25.97	22817900
611	Ubiquitination	DLVEVKPKMVMTVFA HHCCCCHHHHHHHHH	38.11	22817900
615	Phosphorylation	VKPKMVMTVFACLMG CCHHHHHHHHHHHHC	10.89	20068231
623	Ubiquitination	VFACLMGKGLNRIK- HHHHHHCCCHHCCC-	46.38	23503661
629	Ubiquitination	GKGLNRIK------- CCCHHCCC-------	51.56	23503661

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLSI_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLSI_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLSI_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PLSI_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.