TM9S2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM9S2_HUMAN
• UniProt AC: Q99805
• Protein Name: Transmembrane 9 superfamily member 2
• Gene Name: TM9SF2
• Organism: Homo sapiens (Human).
• Sequence Length: 663
• Subcellular Localization: Endosome membrane ; Multi-pass membrane protein .
• Protein Description: In the intracellular compartments, may function as a channel or small molecule transporter..
• Protein Sequence: MSARLPVLSPPRWPRLLLLSLLLLGAVPGPRRSGAFYLPGLAPVNFCDEEKKSDECKAEIELFVNRLDSVESVLPYEYTAFDFCQASEGKRPSENLGQVLFGERIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVEDGQRFCNPGFPIGCYITDKGHAKDACVISSDFHERDTFYIFNHVDIKIYYHVVETGSMGARLVAAKLEPKSFKHTHIDKPDCSGPPMDISNKASGEIKIAYTYSVSFEEDDKIRWASRWDYILESMPHTHIQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQEEFGWKLVHGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGYVAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCISVPLTFIGAYFGFKKNAIEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNSIWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHYFFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSARLPVLS ------CCCCCCCCC	23.30	24043423
9	Phosphorylation	SARLPVLSPPRWPRL CCCCCCCCCCCHHHH	32.85	24719451
20	Phosphorylation	WPRLLLLSLLLLGAV HHHHHHHHHHHHCCC	19.55	-
90	Ubiquitination	FCQASEGKRPSENLG HHHHCCCCCCCCCCH	58.02	-
93	O-linked_Glycosylation	ASEGKRPSENLGQVL HCCCCCCCCCCHHHH	43.05	OGP
104	Methylation	GQVLFGERIEPSPYK HHHHCCCCCCCCCCE	38.66	115918597
120	S-palmitoylation	TFNKKETCKLVCTKT EECCCCEEEEEEEEE	3.17	21044946
124	S-palmitoylation	KETCKLVCTKTYHTE CCEEEEEEEEECCCC	4.71	21044946
126	Ubiquitination	TCKLVCTKTYHTEKA EEEEEEEEECCCCCC	41.79	-
136	Acetylation	HTEKAEDKQKLEFLK CCCCCCHHHHHHHHH	40.62	12435597
174	S-palmitoylation	VEDGQRFCNPGFPIG CCCCCEECCCCCCCE	7.00	29575903
182	S-palmitoylation	NPGFPIGCYITDKGH CCCCCCEEEECCCCC	1.99	29575903
183	Phosphorylation	PGFPIGCYITDKGHA CCCCCEEEECCCCCC	11.14	28152594
185	Phosphorylation	FPIGCYITDKGHAKD CCCEEEECCCCCCCE	12.75	28152594
187	2-Hydroxyisobutyrylation	IGCYITDKGHAKDAC CEEEECCCCCCCEEE	43.90	-
191	Ubiquitination	ITDKGHAKDACVISS ECCCCCCCEEEEEEC	39.94	-
197	Phosphorylation	AKDACVISSDFHERD CCEEEEEECCCCCCC	11.94	23312004
198	Phosphorylation	KDACVISSDFHERDT CEEEEEECCCCCCCE	32.92	23312004
217	Phosphorylation	NHVDIKIYYHVVETG EECEEEEEEEEHHCC	5.19	27642862
218	Phosphorylation	HVDIKIYYHVVETGS ECEEEEEEEEHHCCC	7.51	-
234	Ubiquitination	GARLVAAKLEPKSFK HHHHHEEECCCCCCC	43.58	-
238	2-Hydroxyisobutyrylation	VAAKLEPKSFKHTHI HEEECCCCCCCCCCC	60.18	-
251	Phosphorylation	HIDKPDCSGPPMDIS CCCCCCCCCCCCCCC	62.81	-
251	O-linked_Glycosylation	HIDKPDCSGPPMDIS CCCCCCCCCCCCCCC	62.81	OGP
270	O-linked_Glycosylation	GEIKIAYTYSVSFEE CEEEEEEEEEEECCC	10.57	OGP
328	Ubiquitination	IMLRTLHKDIARYNQ HHHHHHHHHHHHHHC	54.68	-
333	Phosphorylation	LHKDIARYNQMDSTE HHHHHHHHHCCCCCH	10.75	27251275
338	Phosphorylation	ARYNQMDSTEDAQEE HHHHCCCCCHHHHHH	28.49	27251275
339	Phosphorylation	RYNQMDSTEDAQEEF HHHCCCCCHHHHHHH	33.35	26471730
423	Ubiquitination	YVAARFYKSFGGEKW HHHHHHHHHHCCCHH	36.27	-
429	Ubiquitination	YKSFGGEKWKTNVLL HHHHCCCHHCCCHHH	58.21	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM9S2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM9S2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM9S2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of TM9S2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.